|
Hypertensive disease
|
0.070 |
Biomarker
|
group |
BEFREE |
To address this, TGR(mREN2)27 rats (a model of angiotensin II-dependent hypertension) were made diabetic for 12 weeks and treated with vehicle (n = 10), valsartan (ARB; n = 7) or sacubitril/valsartan (ARNI; n = 8) for the final 3 weeks.
|
31790054 |
2020 |
|
Hypertensive disease
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Female rats harboring the human angiotensinogen gene [TGR(hAogen)L1623] develop a preeclamptic phenotype with hypertension and albuminuria during pregnancy when mated with male rats bearing the human renin gene [TGR(hRen)L10J] but behave physiologically normal before and after pregnancy.
|
31786987 |
2020 |
|
Hypertensive disease
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Chronically elevated Ang II in TGR(hAGT)L1623 hearts leading to increased intracellular calcium through I<sub>Ca-L</sub> suggests that activation of this Ang-(1-12)/chymase-governed cardiac intracrine RAS may contribute to the pathological phenotypes observed in the humanized model of chronic hypertension and cardiac hypertrophy.
|
31629566 |
2019 |
|
Hypertensive disease
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Remarkably, in TGR with established hypertension, AAA also decreased SBP (from 187 ± 4 to 158 ± 4 mmHg, <i>P</i><0.05) and exhibited organoprotective effects in addition to marked suppression of kidney ANG II levels.
|
30054426 |
2018 |
|
Hypertensive disease
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Animal models of hypertension have ranged from Goldblatt's kidney clip models in which the origin of the disease is clearly renal to animals that spontaneously develop hypertension either through targeted genetic manipulations, such as the TGR(mRen2)27, or selective breeding resulting in more enigmatic origins, as exemplified by the spontaneously hypertensive rat (SHR).
|
28353076 |
2017 |
|
Hypertensive disease
|
0.070 |
Biomarker
|
group |
BEFREE |
Compared with Sprague-Dawley (SD) control rats (n= 11), male homozygous TGR(hAGT)L1623 (n= 9) demonstrated sustained daytime and nighttime hypertension associated with no changes in heart rate but increased heart rate lability.
|
26873967 |
2016 |
|
Hypertensive disease
|
0.070 |
Biomarker
|
group |
BEFREE |
Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats.
|
7699997 |
1994 |
|
Myocardial Infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the relationship between genetic polymorphisms in the mitochondrial thioredoxin reductase 2 (TrxR2) and myocardial infarction (MI) in subjects with type 2 diabetes mellitus (T2DM) of Slovenian origin.
|
25703281 |
2015 |
|
Malignant Hypertension
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study was performed to determine if urinary angiotensinogen excretion is increased in Cyp1a1-Ren2 transgenic rats [strain name: TGR(Cyp1aRen2)] with inducible ANG II-dependent malignant hypertension.
|
20724906 |
2010 |
|
Parkinson Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Given the interdependence between adenosinic and dopaminergic function, the present results render the novel TGR(NSEhA2A) as a putative animal model for the working memory deficits and cognitive disruptions related to overstimulation of cortical A(2A)Rs or to dopaminergic prefrontal dysfunction as seen in schizophrenic or Parkinson's disease patients.
|
16824773 |
2007 |
|
Myocardial Infarction
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, despite similar unchanged infarction sizes, left ventricular function and remodeling improved in TGR(hKLK1) after myocardial infarction, indicated by an increase in left ventricular pressure (+34%; P<0.05), contractility (dp/dt max.
|
17022964 |
2006 |
|
Parkinson Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The human TR2 gene is located on chromosome 2q32.3, near a locus linked to Parkinson's disease.
|
16805794 |
2006 |
|
Malignant Hypertension
|
0.020 |
Biomarker
|
disease |
BEFREE |
TGR(mREN2)27 heterozygotes (HanRen2/Edin- -) have previously been shown to develop malignant hypertension spontaneously and exhibit the characteristic features of human malignant hypertension.
|
9797175 |
1998 |
|
Portal Hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
TGR(mREN2)27 rats developed spontaneous, but mild fibrosis and portal hypertension due to the activation of the JAK2/Arhgef1/ROCK pathway.
|
31406138 |
2019 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
The extent of liver fibrosis was assessed in TGR(mREN2)27 and wild-type rats using standard techniques.
|
31406138 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we used TGR(mREN2)27 rats as a model of NAFLD where we hypothesized increased susceptibility and investigated fibrosis and portal hypertension and associated pathways.
|
31406138 |
2019 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among patients having good response (n=112, ACT score increased ≥3 points) to tiotropium (TGR group) and patients having poor response (n=48, ACT increased <3 points) to tiotropium (TPR group), their baseline characteristics including age, asthma and chronic obstructive pulmonary disease (COPD) overlap (ACO), cigarette use, initial FEV1, serum IgE level, eosinophil count, and BMI were significantly different.
|
30069364 |
2018 |
|
Hyperthyroidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to investigate the effects of elevated circulating Ang-(1-7) levels on cardiac effects promoted by hyperthyroidism in a transgenic rat (TG) model that constitutively overexpresses an Ang-(1-7)-producing fusion protein [TGR(A1-7)3292].
|
29685981 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among patients having good response (n=112, ACT score increased ≥3 points) to tiotropium (TGR group) and patients having poor response (n=48, ACT increased <3 points) to tiotropium (TPR group), their baseline characteristics including age, asthma and chronic obstructive pulmonary disease (COPD) overlap (ACO), cigarette use, initial FEV1, serum IgE level, eosinophil count, and BMI were significantly different.
|
30069364 |
2018 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
TGR(ASrAOGEN) were protected from developing obesity.
|
29430615 |
2018 |
|
Parasitic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Thioredoxin glutathione reductase (TGR), a high molecular weight thioredoxin reductase-like enzyme, has emerged as a promising drug target for the treatment of schistosomiasis, a parasitosis afflicting more than 200 million people.
|
29800515 |
2018 |
|
Schistosomiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thioredoxin glutathione reductase (TGR), a high molecular weight thioredoxin reductase-like enzyme, has emerged as a promising drug target for the treatment of schistosomiasis, a parasitosis afflicting more than 200 million people.
|
29800515 |
2018 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In recent years, a plethora of TGR-β have been developed and some of them are under clinical investigations for testing in patients with advanced HCC.
|
29150921 |
2018 |
|
Multiple Chronic Conditions
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thioredoxin glutathione reductase (TGRsec) is a multi-domain flavoprotein that plays a principal role in redox homeostasis maintenance.
|
30205085 |
2018 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
The previously identified let-7i-5p, miR-16-5p, miR-18a-5p, miR-26b-5p, miR-27a-3p, miR-30e-5p, miR-199a-3p, miR-223-3p, miR-423-3p, miR-423-5p and miR-652-3p were measured by means of quantitative real time polymerase chain reaction (qRT-PCR) in plasma samples of 8 homozygous TGR(mREN2)27 (Ren2) transgenic rats and 8 (control) Sprague-Dawley rats, 6 mice with angiotensin II-induced heart failure (AngII) and 6 control mice, and 8 mice with ischemic heart failure and 6 controls.
|
28475616 |
2017 |