|
Idiopathic generalized epilepsy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The area where the LOD score reaches the maximum encompasses the location of the gene for the beta3-subunit of the nicotinic acetylcholine receptor (CHRNB3), thus making this gene a possible candidate for these specific forms of adolescent-onset IGE.
|
10205274 |
1999 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found nominally significant (P<0.05) allelic and genotypic association with smoking initiation of SNP rs2072660 and multilocus haplotypes (P<0.007-0.05) in CHRNB2 and nominal (P<0.05) allelic or genotypic association of SNPs in CHRNA7 (rs1909884), CHRNA9 (rs4861065) and CHRNB3 (rs9298629) with nicotine dependence.
|
16314871 |
2006 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Mental Depression
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Depressive disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The CHRNA6 and CHRNB3 genes have been associated with nicotine dependence and early subjective response to nicotine.
|
19500157 |
2009 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Together these results further implicate the region downstream of CHRNA6 and the region upstream of CHRNB3 in risk of nicotine dependence.
|
18704094 |
2009 |
|
Tobacco Dependence
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.
|
18704094 |
2009 |
|
TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
|
20418888 |
2010 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we test the hypothesis that the nicotinic receptor genes CHRNA5 (rs16969968), CHRNA3 (rs578776), CHRNB3 (rs13277254) and CHRND (rs12466358) modify the risk for nicotine dependence associated with peer smoking.
|
20840187 |
2010 |
|
Nicotine Dependence
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among the genes at the two newly associated loci are genes encoding nicotine-metabolizing enzymes (CYP2A6 and CYP2B6) and nicotinic acetylcholine receptor subunits (CHRNB3 and CHRNA6), all of which have been highlighted in previous studies of smoking and nicotine dependence.
|
20418888 |
2010 |
|
Smoking Behaviors
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
|
20418888 |
2010 |
|
Dizziness
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Multiple SNPs in the putative promoter region of the CHRNB3 gene were nominally associated with "dizziness" experience from the first few cigarettes (P < 0.01).
|
19760673 |
2010 |
|
Vertigo
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Multiple SNPs in the putative promoter region of the CHRNB3 gene were nominally associated with "dizziness" experience from the first few cigarettes (P < 0.01).
|
19760673 |
2010 |
|
Bipolar Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
In the investigation of pleiotropic effects of these SNPs on bipolar disorder, two highly correlated synonymous SNPs in CHRNB3, rs4952 and rs4953, were significantly associated with bipolar disorder (odds ratio 1.7, 95% confidence interval: 1.2-2.4, P=0.001).
|
21191315 |
2011 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Our results suggest that (i) bipolar disorder does not modify the association between nicotine dependence and nicotinic receptor subunit genes, and (ii) variants in CHRNB3/CHRNA6 are independently associated with bipolar disorder.
|
21191315 |
2011 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that (i) bipolar disorder does not modify the association between nicotine dependence and nicotinic receptor subunit genes, and (ii) variants in CHRNB3/CHRNA6 are independently associated with bipolar disorder.
|
21191315 |
2011 |
|
Nicotine Dependence
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies have identified common variation in the CHRNA5-CHRNA3-CHRNB4 and CHRNA6-CHRNB3 gene clusters that contribute to nicotine dependence.
|
22042774 |
2012 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genetic locus most strongly associated with nicotine dependence was rs1451240 on chromosome 8 in the region of CHRNB3 [odds ratio (OR) = 0.65, P = 2.4 × 10(-8) ].
|
22524403 |
2012 |
|
Nicotine Dependence
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results provided confirmation of the previous findings that DRD2, DRD3, DDC, CHRNB3, GABBR2 and CHRNA4 are associated with nicotine dependence.
|
22309839 |
2012 |
|
Attention deficit hyperactivity disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, a significant CHRNB3 variant×ADHD symptom interaction was observed, such that individuals with elevated ADHD symptoms and a particular CHRNB3 variant were at increased risk of cigarette use over time.
|
23899432 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Replication in an independent sample supports the role of rare variants in CHRNB3 and alcohol dependence (P = 0.006).
|
24057674 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Replication in an independent sample supports the role of rare variants in CHRNB3 and alcohol dependence (P = 0.006).
|
24057674 |
2014 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
These results suggest that the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.
|
24675634 |
2014 |
|
Bipolar Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.
|
24675634 |
2014 |