|
Alcoholic Intoxication, Chronic
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
In a real data application, we apply our method to the sequencing data from Minnesota Twin Study (MTS) and found potential associations of several nicotine receptor subunit (CHRN) genes, including CHRNB3, associated with nicotine dependence and/or alcohol dependence.
|
28850771 |
2017 |
|
Alcoholic Intoxication, Chronic
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Replication in an independent sample supports the role of rare variants in CHRNB3 and alcohol dependence (P = 0.006).
|
24057674 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Replication in an independent sample supports the role of rare variants in CHRNB3 and alcohol dependence (P = 0.006).
|
24057674 |
2014 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
These results suggest that the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.
|
24675634 |
2014 |
|
Bipolar Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.
|
24675634 |
2014 |
|
Cocaine Dependence
|
0.320 |
Biomarker
|
disease |
PSYGENET |
For European Americans, we find increased DSM-IV cocaine dependence symptoms (FamSKAT P = 2 × 10(-4)) and increased DSM-IV alcohol dependence symptoms (FamSKAT P = 5 × 10(-4)) among carriers of missense variants in CHRNB3.
|
24057674 |
2014 |
|
Cocaine Dependence
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence.
|
24057674 |
2014 |
|
Cocaine Dependence
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The common variant rs13273442 in the CHRNB3-CHNRA6 region is associated significantly with nicotine dependence in European Americans and African Americans across studies recruited for nicotine, alcohol and cocaine dependence.
|
24401102 |
2014 |
|
Bipolar Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
In the investigation of pleiotropic effects of these SNPs on bipolar disorder, two highly correlated synonymous SNPs in CHRNB3, rs4952 and rs4953, were significantly associated with bipolar disorder (odds ratio 1.7, 95% confidence interval: 1.2-2.4, P=0.001).
|
21191315 |
2011 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Our results suggest that (i) bipolar disorder does not modify the association between nicotine dependence and nicotinic receptor subunit genes, and (ii) variants in CHRNB3/CHRNA6 are independently associated with bipolar disorder.
|
21191315 |
2011 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
cocaine use
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Using genotypic data from a GWAS of the Study of Addiction: Genetics and Environment (SAGE) dataset, we tested for association of CHRNB3-A6 SNPs with DSM-5 cocaine use disorder.
|
24675634 |
2014 |
|
TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
|
20418888 |
2010 |
|
Mental Depression
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Depressive disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the context of personalized medicine, the aims of this study were to evaluate whether cholinergic receptor nicotinic alpha 2 (CHRNA2), cholinergic receptor nicotinic alpha 3 (CHRNA3), cholinergic receptor nicotinic alpha 5 (CHRNA5) and cholinergic receptor nicotinic beta 3 (CHRNB3) polymorphisms were associated with nicotine dependence severity, and to investigate possible pharmacogenetics markers of smoking cessation treatment.
|
29621993 |
2018 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a real data application, we apply our method to the sequencing data from Minnesota Twin Study (MTS) and found potential associations of several nicotine receptor subunit (CHRN) genes, including CHRNB3, associated with nicotine dependence and/or alcohol dependence.
|
28850771 |
2017 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, our meta-analysis of samples with Asian and European origins for five SNPs in CHRNB3 showed significant associations with ND, with p-values ranging from 6.86 × 10<sup>-14</sup> for rs13280604 to 6.50 × 10<sup>-8</sup> for rs4950<sup>.</sup> This represents the first study showing that CHRNB3/A6 are highly associated with ND in a large Chinese Han sample.
|
28851948 |
2017 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Besides the CHRNA4, CHRNB2 and CHRNA5/A3/B4 cluster on chromosome 15, which has been investigated intensively, recent evidence from both genome-wide association studies and candidate gene-based association studies has revealed the crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence (ND).
|
27327258 |
2016 |
|
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.
|
26440539 |
2015 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We previously undertook pooled sequencing of the coding regions and flanking sequence of the CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 genes and found that rare missense variants at conserved residues in CHRNB4 are associated with reduced risk of nicotine dependence among African Americans.
|
24804708 |
2014 |
|
Nicotine Dependence
|
0.100 |
Biomarker
|
disease |
BEFREE |
The β3 nicotinic-acetylcholine receptor subunit (encoded by CHRNB3) is depleted in the striatum of PD patients and associated with nicotine dependence.
|
24731518 |
2014 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.
|
24675634 |
2014 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The common variant rs13273442 in the CHRNB3-CHNRA6 region is associated significantly with nicotine dependence in European Americans and African Americans across studies recruited for nicotine, alcohol and cocaine dependence.
|
24401102 |
2014 |
|
Nicotine Dependence
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies have identified common variation in the CHRNA5-CHRNA3-CHRNB4 and CHRNA6-CHRNB3 gene clusters that contribute to nicotine dependence.
|
22042774 |
2012 |