|
Cocaine Dependence
|
0.320 |
Biomarker
|
disease |
PSYGENET |
For European Americans, we find increased DSM-IV cocaine dependence symptoms (FamSKAT P = 2 × 10(-4)) and increased DSM-IV alcohol dependence symptoms (FamSKAT P = 5 × 10(-4)) among carriers of missense variants in CHRNB3.
|
24057674 |
2014 |
|
Cocaine Dependence
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence.
|
24057674 |
2014 |
|
Cocaine Dependence
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The common variant rs13273442 in the CHRNB3-CHNRA6 region is associated significantly with nicotine dependence in European Americans and African Americans across studies recruited for nicotine, alcohol and cocaine dependence.
|
24401102 |
2014 |
|
cocaine use
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Using genotypic data from a GWAS of the Study of Addiction: Genetics and Environment (SAGE) dataset, we tested for association of CHRNB3-A6 SNPs with DSM-5 cocaine use disorder.
|
24675634 |
2014 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We previously undertook pooled sequencing of the coding regions and flanking sequence of the CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 genes and found that rare missense variants at conserved residues in CHRNB4 are associated with reduced risk of nicotine dependence among African Americans.
|
24804708 |
2014 |
|
Nicotine Dependence
|
0.100 |
Biomarker
|
disease |
BEFREE |
The β3 nicotinic-acetylcholine receptor subunit (encoded by CHRNB3) is depleted in the striatum of PD patients and associated with nicotine dependence.
|
24731518 |
2014 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.
|
24675634 |
2014 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The common variant rs13273442 in the CHRNB3-CHNRA6 region is associated significantly with nicotine dependence in European Americans and African Americans across studies recruited for nicotine, alcohol and cocaine dependence.
|
24401102 |
2014 |
|
Malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Although gene polymorphisms on nicotinic acetylcholine receptor subunits CHRNB3-CHRNA6 region gene have been found to correlate with smoking behavior and lung cancer susceptibility in Chinese Han population, the combined effect between the smoking-related genetic variants and smoking behavior on psoriasis vulgaris (PV) has been unreported.
|
24792900 |
2014 |
|
Carcinoma of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Although gene polymorphisms on nicotinic acetylcholine receptor subunits CHRNB3-CHRNA6 region gene have been found to correlate with smoking behavior and lung cancer susceptibility in Chinese Han population, the combined effect between the smoking-related genetic variants and smoking behavior on psoriasis vulgaris (PV) has been unreported.
|
24792900 |
2014 |
|
Primary malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Although gene polymorphisms on nicotinic acetylcholine receptor subunits CHRNB3-CHRNA6 region gene have been found to correlate with smoking behavior and lung cancer susceptibility in Chinese Han population, the combined effect between the smoking-related genetic variants and smoking behavior on psoriasis vulgaris (PV) has been unreported.
|
24792900 |
2014 |
|
Alcohol Use Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
More recent studies in family-based samples have implicated GABRA2, nicotinic receptor genes such as CHRNB3, and a number of other specific single genes as associated with alcohol use disorders.
|
25399692 |
2014 |
|
Parkinson Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the CHRNB3 c.-57A>G alteration affects the promoter activity and is associated with PD and smoking in PD patients.
|
24731518 |
2014 |
|
Psoriasis vulgaris
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the combined effect of the smoking-related (rs6474412-C/T) polymorphism on CHRNB3-CHRNA6 region gene and smoking behavior on PV risk and clinic traits in Chinese Han population.
|
24792900 |
2014 |
|
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.
|
26440539 |
2015 |
|
Cannabis Abuse
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.
|
25770649 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that this CHRNB3-A6 variant confers susceptibility to ESCC risk.
|
25823894 |
2015 |
|
Nicotine Dependence
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Besides the CHRNA4, CHRNB2 and CHRNA5/A3/B4 cluster on chromosome 15, which has been investigated intensively, recent evidence from both genome-wide association studies and candidate gene-based association studies has revealed the crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence (ND).
|
27327258 |
2016 |
|
Malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Nicotinic acetylcholine receptors (nAChRs) play a key role in carcinogenesis and progression of lung cancer; and polymorphisms in CHRNA5-A3 and CHRNB3-A6, two gene clusters encoding nAChR subunits, have been associated with lung cancer risk.
|
27050379 |
2016 |
|
Carcinoma of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Nicotinic acetylcholine receptors (nAChRs) play a key role in carcinogenesis and progression of lung cancer; and polymorphisms in CHRNA5-A3 and CHRNB3-A6, two gene clusters encoding nAChR subunits, have been associated with lung cancer risk.
|
27050379 |
2016 |
|
Primary malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Nicotinic acetylcholine receptors (nAChRs) play a key role in carcinogenesis and progression of lung cancer; and polymorphisms in CHRNA5-A3 and CHRNB3-A6, two gene clusters encoding nAChR subunits, have been associated with lung cancer risk.
|
27050379 |
2016 |
|
Malignant Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
To test whether rs1051730 (C/T), a tag for multiple variants in the CHRNA5-CHRNA3-CHRNB3 cluster, is associated with a change in risk of smoking-related mortality and morbidity in the Malmö Diet and Cancer study, a population-based prospective cohort study.
|
26689306 |
2016 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of CHRNA5-A3 and CHRNB3-A6 predict survival of patients with advanced non-small cell lung cancer.
|
27050379 |
2016 |
|
Antisocial behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.
|
27085880 |
2016 |
|
Carcinogenesis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Nicotinic acetylcholine receptors (nAChRs) play a key role in carcinogenesis and progression of lung cancer; and polymorphisms in CHRNA5-A3 and CHRNB3-A6, two gene clusters encoding nAChR subunits, have been associated with lung cancer risk.
|
27050379 |
2016 |