TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Disease: Unipolar Depression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 GeneticVariation disease BEFREE There was no association between TPH-2 gene variants and MD in the same population that had shown a strong association with TPH-1. 17692928 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 GeneticVariation disease BEFREE This SNP and additional SNPs were discovered through a systematic characterization of the genetic architecture of the TPH2 gene for further genetic and functional investigations of its relationship to major depression and other psychopathology. 18180764 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 Biomarker disease MGD Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. 18212115 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 GeneticVariation disease BEFREE Genetic variations in the TPH2 gene have been associated with an increased risk for major depression and suicidal behavior. 17251907 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 Biomarker disease BEFREE Markers in TPH2 have been implicated in suicide and major depressive disorder, but the results across studies are inconsistent. 16806105 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 GeneticVariation disease BEFREE Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression. 17217922 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 Biomarker disease CTD_human Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. 17950541 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 AlteredExpression disease BEFREE Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. 16192985 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 GeneticVariation disease BEFREE Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. 15629698 2005
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 GeneticVariation disease BEFREE Our findings provide evidence for an involvement of genetic variants of the TPH2 gene in the pathogenesis of MD and might be a hint on the repeatedly discussed duality of the serotonergic system. 15124006 2004