ATF2, activating transcription factor 2, 1386

N. diseases: 122; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.370 GeneticVariation disease UNIPROT
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.370 GeneticVariation disease BEFREE Genetic variants of the ATF-2 gene were detected in 5 of the 46 (10.6%) lung cancers, but not in neuroblastomas and breast cancers. 11836564 2002
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.370 GeneticVariation disease BEFREE In summary, the variant alleles of TSG101 rs2292179 and ATF2 rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 (kg/m(2)) and postmenopausal women, respectively. 26729199 2016
CUI: C0025048
Disease: Meconium Aspiration Syndrome
Meconium Aspiration Syndrome 		0.210 GeneticVariation phenotype BEFREE Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome. 10364225 1999
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.110 GeneticVariation disease GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.100 GeneticVariation disease BEFREE Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells. 15531295 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.100 GeneticVariation disease BEFREE The imaging-based ATF2 translocation assay was conducted using UACC903 melanoma cells that stably express doxycycline-inducible GFP-ATF2. 23589174 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 GeneticVariation disease BEFREE To assess the role of the ATF-2 gene as a tumor suppressor in human carcinogenesis, we examined genetic alterations of the ATF-2 gene in 9 breast cancer cell lines, 10 neuroblastoma cell lines and 46 lung cancer cell lines. 11836564 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 GeneticVariation disease BEFREE In summary, the variant alleles of TSG101 rs2292179 and ATF2 rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 (kg/m(2)) and postmenopausal women, respectively. 26729199 2016
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.070 GeneticVariation phenotype BEFREE To assess the role of the ATF-2 gene as a tumor suppressor in human carcinogenesis, we examined genetic alterations of the ATF-2 gene in 9 breast cancer cell lines, 10 neuroblastoma cell lines and 46 lung cancer cell lines. 11836564 2002
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.050 GeneticVariation disease BEFREE Genetic variants of the ATF-2 gene were detected in 5 of the 46 (10.6%) lung cancers, but not in neuroblastomas and breast cancers. 11836564 2002
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 GeneticVariation disease BEFREE Infrequent mutations of the activating transcription factor-2 gene in human lung cancer, neuroblastoma and breast cancer. 11836564 2002
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.050 GeneticVariation disease BEFREE Infrequent mutations of the activating transcription factor-2 gene in human lung cancer, neuroblastoma and breast cancer. 11836564 2002
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.020 GeneticVariation disease BEFREE We found increased phospho-STAT3 in RA patients, and some targets, including phospho-ATF2, acquired time-of-day variation in RA. 30728072 2019
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.020 GeneticVariation disease LHGDN Genetic variants of the ATF-2 gene were detected in 5 of the 46 (10.6%) lung cancers, but not in neuroblastomas and breast cancers. 11836564 2002
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.020 GeneticVariation disease BEFREE Genetic variants of the ATF-2 gene were detected in 5 of the 46 (10.6%) lung cancers, but not in neuroblastomas and breast cancers. 11836564 2002
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.020 GeneticVariation disease BEFREE Thus, in conclusions, the three lncRNAs (LINC00028, LINC00323 and SNHG1), two miRNAs (hsa‑miR‑124 and hsa‑miR‑7) and three mRNAs (RAP1B, ATF2, and PPM1B) were associated with osteosarcoma recurrence. 30816442 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.020 GeneticVariation disease BEFREE Thus, in conclusions, the three lncRNAs (LINC00028, LINC00323 and SNHG1), two miRNAs (hsa‑miR‑124 and hsa‑miR‑7) and three mRNAs (RAP1B, ATF2, and PPM1B) were associated with osteosarcoma recurrence. 30816442 2019
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.020 GeneticVariation disease BEFREE Thus, in conclusions, the three lncRNAs (LINC00028, LINC00323 and SNHG1), two miRNAs (hsa‑miR‑124 and hsa‑miR‑7) and three mRNAs (RAP1B, ATF2, and PPM1B) were associated with osteosarcoma recurrence. 30816442 2019
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.010 GeneticVariation disease BEFREE The most strongly CD risk-associated, non-coding DMBT1 SNP rs2981804 modifies the DNA binding sites for the transcription factors CREB1 and ATF-2 and the respective genomic region comprising rs2981804 is able to act as a transcriptional regulator in vitro. 24223725 2013
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.010 GeneticVariation group BEFREE The B cell-specific deletion of ATF2 and ATF7 in mice results in significantly accelerated onset of Eμ-Myc-induced lymphoma. 23416976 2014
CUI: C0035220
Disease: Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Newborn 		0.010 GeneticVariation disease BEFREE The ATF-2 null mutants should enhance our understanding of the mechanism of severe neonatal respiratory distress. 10364225 1999
CUI: C0085390
Disease: Li-Fraumeni Syndrome
Li-Fraumeni Syndrome 		0.010 GeneticVariation disease BEFREE While 11 genes (ATP-binding cassette, sub-family G (WHITE), member 2(ABCG2), activating transcription factor (ATF2), beta-2-microglobulin (B2M), deoxycytidine kinase (DCK), occludin (OCLN), v-raf-1 murine leukemia viral oncogene homolog (RAF1), ralA binding protein 1 (RALBP1), splicing factor (45 kD) (SPF45), S-phase kinase-associated protein 2 (p45) (SKP2), tumor protein p53 (Li-Fraumeni syndrome) (TP53) and topoisomerase (DNA) II beta (TOP2B)) maintained the unmethylated patterns, three genes displayed to various extents the hypermethylation state in tumor tissues in comparison with the normal counterparts. 15526362 2004
CUI: C0235820
Disease: Neonatal encephalopathy
Neonatal encephalopathy 		0.010 GeneticVariation disease BEFREE A neonatal encephalopathy with seizures in standard poodle dogs with a missense mutation in the canine ortholog of ATF2. 18074159 2008
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma 		0.010 GeneticVariation disease BEFREE The B cell-specific deletion of ATF2 and ATF7 in mice results in significantly accelerated onset of Eμ-Myc-induced lymphoma. 23416976 2014