|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the present study demonstrated that Ufm 1 could activate NF-κB pathway by downregulating LZAP in macrophage of diabetes and its expression and activation was regulated by JNK/ATF2 and c-Jun pathway.
|
31829413 |
2020 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In conclusion, the present study demonstrated that Ufm 1 could activate NF-κB pathway by downregulating LZAP in macrophage of diabetes and its expression and activation was regulated by JNK/ATF2 and c-Jun pathway.
|
31829413 |
2020 |
|
CNS disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Taken together, our data first proved the pro-inflammatory function of ATF2 in microglia, and suggested that the TRAF6-JNK/p38-ATF2 axis might promote microglial inflammatory activation and thus aggravate neuronal injury in brain, which might become a potential therapeutic target for CNS diseases.
|
30763583 |
2019 |
|
Diabetic Retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to explore the role of microRNA-451a (miR-451a) in diabetic retinopathy through activating transcription factor 2 (ATF2).
|
30576241 |
2019 |
|
Ehlers-Danlos Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consistently, the patients' fibroblasts displayed impaired JNK1- and c-Jun/ATF-2-dependent induction of key extracellular matrix (ECM) components and regulators, but not of EDS-causing gene products, in response to TGF-β.
|
31784499 |
2019 |
|
Pulmonary Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The atorvastatin treatments to mice with PF resulted in significant increases at the TGF-β activation, cell proliferation and kidney damage and decreases in the levels of p-SMAD2, p-ELK1, p-ATF2 and p-c-Jun, but not change the p-SMAD3, ELK1 and ATF2 in kidneys.
|
31215034 |
2019 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression levels of genes responsible for liver fibrosis (TGF-α) and cell regeneration (MKK4, MKK7, and ATF2) have been measured by RT-PCR analysis.
|
31418419 |
2019 |
|
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, miR-451a/ATF2 plays a vital role in the regulation of proliferation and migration in RPE cells through regulation of mitochondrial function, which may provide new perspectives for developing effective therapies for PDR.
|
30576241 |
2019 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protein Kinase Cθ Via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6C<sup>hi</sup> Cells Contributes to Atherosclerosis.
|
29991487 |
2018 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protein Kinase Cθ Via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6C<sup>hi</sup> Cells Contributes to Atherosclerosis.
|
29991487 |
2018 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, immunohistochemistry in surgical specimens demonstrated significant elevation of ATF2/phospho-ATF2/phospho-ERK expression in bladder tumors, compared with non-neoplastic urothelial tissues.
|
30521479 |
2018 |
|
Fetal Growth Retardation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The protein levels of activating transcription factor 2 (Atf2) and Atf6, two key factors of the UPR pathway, were upregulated in the livers of IUGR foetuses, and the latter remained upregulated until 12 weeks.
|
30524373 |
2018 |
|
Hepatitis
|
0.010 |
Biomarker
|
group |
BEFREE |
The up-regulation of HMGB1 was thought to be modified by dual channels: in the transcriptional level, it was regulated by JNK1/JNK2-ATF2 axis; post-transcriptionally, it was regulated by the microRNA (miR)-200 family, especially miR-429. miR-429 liver conditional knockout mice (miR-429<sup>Δhep</sup>), fed either a normal diet or an HFD, showed severe liver inflammation and dysfunction, accompanied by greater expression of HMGB1.
|
29298863 |
2018 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The purpose of this study was to investigate the contribution of ATF2 and ATF3 to nerve injury-induced neuropathic pain.
|
29921170 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings reveal a novel mechanism by which HMGB1 expression was regulated by both the JNK1/2-ATF2 axis and the miR-200 family, which provides a potential new approach for the treatment of NAFLD.-Chen, X., Ling, Y., Wei, Y., Tang, J., Ren, Y., Zhang, B., Jiang, F., Li, H., Wang, R., Wen, W., Lv, G., Wu, M., Chen, L., Li, L., Wang, H. Dual regulation of HMGB1 by combined JNK1/2-ATF2 axis with miR-200 family in nonalcoholic steatohepatitis in mice.
|
29298863 |
2018 |
|
Tactile Allodynia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Repeated intrathecal post-treatment with a small-interfering RNA targeted against ATF2 (ATF2 siRNA) or anti-ATF2 antibody partially reversed tactile allodynia and thermal hyperalgesia.
|
29921170 |
2018 |
|
Nonalcoholic Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings reveal a novel mechanism by which HMGB1 expression was regulated by both the JNK1/2-ATF2 axis and the miR-200 family, which provides a potential new approach for the treatment of NAFLD.-Chen, X., Ling, Y., Wei, Y., Tang, J., Ren, Y., Zhang, B., Jiang, F., Li, H., Wang, R., Wen, W., Lv, G., Wu, M., Chen, L., Li, L., Wang, H. Dual regulation of HMGB1 by combined JNK1/2-ATF2 axis with miR-200 family in nonalcoholic steatohepatitis in mice.
|
29298863 |
2018 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
OV-90 cells with p38α and ATF2 gene being silenced grew significantly slow and were significantly sensitive to the chemotherapy compared to cells with high p38α and ATF2 expression. p38α and ATF2 expression play a crucial role in the malignant phenotypes of ovarian tumor cells and are a marker for the poor prognosis of patients with ovarian serous adenocarcinomas.
|
28916425 |
2017 |
|
Cystic Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altogether, these data suggest that ATF2 could be a potential target to prevent inflammation-induced P. aeruginosa binding in the lung of patients suffering from lung diseases such as chronic bronchitis or cystic fibrosis.
|
27821620 |
2017 |
|
Lung diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Altogether, these data suggest that ATF2 could be a potential target to prevent inflammation-induced P. aeruginosa binding in the lung of patients suffering from lung diseases such as chronic bronchitis or cystic fibrosis.
|
27821620 |
2017 |
|
Paroxysmal nocturnal hemoglobinuria
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By pathway analysis, we identified novel signaling pathways in T cell subsets from PNH, including increased gene expression involved in TNFR, IGF1, NOTCH, AP-1, and ATF2 pathways.
|
28630090 |
2017 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling.
|
29178939 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Positive p38α and ATF2 expression were significantly associated with high clinical stage (III/IV), lymph node metastasis, and shorter overall survival.
|
28916425 |
2017 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
KLF4 silencing by promoter deoxyribonucleic acid (DNA) methylation in patients with T-ALL leads to aberrant activation of the mitogen-activated protein kinase kinase MAP2K7 and the downstream c-Jun NH<sub>2</sub>-terminal kinase (JNK) pathway that controls the expansion of leukemia cells via c-Jun and activating transcription factor 2.
|
28479419 |
2017 |
|
Primary cholangiocarcinoma of intrahepatic biliary tract
|
0.010 |
Biomarker
|
disease |
BEFREE |
Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling.
|
29178939 |
2017 |