|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
OV-90 cells with p38α and ATF2 gene being silenced grew significantly slow and were significantly sensitive to the chemotherapy compared to cells with high p38α and ATF2 expression. p38α and ATF2 expression play a crucial role in the malignant phenotypes of ovarian tumor cells and are a marker for the poor prognosis of patients with ovarian serous adenocarcinomas.
|
28916425 |
2017 |
|
Adult Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Next, we showed by immunohistochemistry that the activated form of ATF2 (ATF-2pp) was highly expressed in six different BL samples.
|
15185015 |
2004 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
An in vivo assay revealed a significant negative correlation between miR-451 and ATF2 in liver cancer tissues.
|
24968707 |
2014 |
|
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The B cell-specific deletion of ATF2 and ATF7 in mice results in significantly accelerated onset of Eμ-Myc-induced lymphoma.
|
23416976 |
2014 |
|
Adult Synovial Sarcoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Together, these studies define a fundamental role for aberrant ATF2 transcriptional dysregulation in the etiology of synovial sarcoma.
|
22439931 |
2012 |
|
Adult Synovial Sarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
ATF2 assembles into a complex with the synovial sarcoma translocation, chromosome 18 (SS18)-synovial sarcoma, X breakpoint (SSX) fusion oncoprotein, and the transducin-like enhancer of split 1 (TLE1) corepressor, driving oncogenesis in synovial sarcoma.
|
24289970 |
2014 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sequence requirements of ATF2 and CREB binding to the human T-cell leukemia virus type 1 LTR R region.
|
8610463 |
1996 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Moreover, SAPK/JNK- and p38-immunoprecipitated sub-cellular fractions enriched in abnormal hyperphosphorylated tau have the capacity to phosphorylate recombinant tau and c-Jun and ATF-2 which are specific substrates of SAPK/JNK and p38 in AD and PiD.
|
15977985 |
2005 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Moreover, SAPK/JNK- and p38-immunoprecipitated sub-cellular fractions enriched in abnormal hyperphosphorylated tau have the capacity to phosphorylate recombinat tau and c-Jun and ATF-2 which are specific substrates of SAPK/JNK and p38 in AD and PiD.
|
15658002 |
2004 |
|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
LHGDN |
Activating transcription factor 2 expression in the adult human brain: association with both neurodegeneration and neurogenesis.
|
15878807 |
2005 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protein Kinase Cθ Via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6C<sup>hi</sup> Cells Contributes to Atherosclerosis.
|
29991487 |
2018 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protein Kinase Cθ Via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6C<sup>hi</sup> Cells Contributes to Atherosclerosis.
|
29991487 |
2018 |
|
Basal cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous squamous cell carcinoma, Bowen's disease and basal cell carcinoma.
|
18547788 |
2008 |
|
Benign Neoplasm
|
0.300 |
Biomarker
|
group |
CTD_human |
Oxidative stress and MAPK involved into ATF2 expression in immortalized human urothelial cells treated by arsenic.
|
23591579 |
2013 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, immunohistochemistry in surgical specimens demonstrated significant elevation of ATF2/phospho-ATF2/phospho-ERK expression in bladder tumors, compared with non-neoplastic urothelial tissues.
|
30521479 |
2018 |
|
Bowen's Disease
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous squamous cell carcinoma, Bowen's disease and basal cell carcinoma.
|
18547788 |
2008 |
|
Breast Carcinoma
|
0.080 |
PosttranslationalModification
|
disease |
BEFREE |
These results indicate that spermine can enhance E2-induced cell signaling and cyclin D1 transcription by activation of the p38 MAP kinase and phosphorylation of ATF-2, contributing to breast cancer cell proliferation.
|
16050133 |
2005 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
While expression of ATF-2 is not associated with outcome, pATF-2 is associated with longer disease-free (p = 0.002) and BC-specific survival in patients exposed to tamoxifen (p = 0.01).
|
25141981 |
2014 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
ATF-2 simultaneously binds to Oct-1, NF-I and breast cancer suppressor BRCA1 to activate transcription.
|
17700520 |
2008 |
|
Breast Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Stable expression of ATF2 in human breast carcinoma BT474 cells increases transcriptional activity and confers resistance to the four DNA-damaging agents, but not to transplatin.
|
12663670 |
2003 |
|
Breast Carcinoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
To assess the role of the ATF-2 gene as a tumor suppressor in human carcinogenesis, we examined genetic alterations of the ATF-2 gene in 9 breast cancer cell lines, 10 neuroblastoma cell lines and 46 lung cancer cell lines.
|
11836564 |
2002 |
|
Breast Carcinoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
In summary, the variant alleles of TSG101 rs2292179 and ATF2 rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 (kg/m(2)) and postmenopausal women, respectively.
|
26729199 |
2016 |
|
Breast Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Atf-2(-/-) MEFs also had a higher saturation density than wild-type cells and expressed lower levels of Maspin, the breast cancer tumor suppressor, which is also known to enhance cellular sensitivity to apoptotic stimuli.
|
17189429 |
2007 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Activating transcription factor 2 (ATF2; also known as cAMP-dependent transcription factor ATF-2) has oncogenic activities in melanoma and tumor suppressor activities in non-malignant skin tumors and breast cancer.
|
22685333 |
2012 |
|
Bronchioloalveolar Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Genes overexpressed in adenocarcinoma with bronchioloalveolar features included fibroblast growth factor receptor 1, and CLDN18 (claudin 18), whereas those overexpressed in BAC included ataxia telangiectasia and Rad3 related (ataxia telangiectasia mutated and Rad3-related), and activating transcription factor 2.
|
22864788 |
2013 |