Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Dysfunction of the CRF system has been observed in stress-related affective disorders including post-traumatic stress disorder, depression, and anxiety.
|
31212019 |
2019 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
We conclude that androgens may directly affect CRH neurons in the human PVN via AR binding to the CRH-ARE, which may have consequences for sex-specific pathogenesis of mood disorders.
|
16446741 |
2006 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The density of RAR-alpha-immunoreactive neurons and CRH-RAR-alpha double-staining neurons was significantly increased in the PVN of patients with affective disorders.
|
19596122 |
2009 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders.
|
17728670 |
2007 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Corticotropin-releasing factor-binding protein (CRF-BP) regulates the availability of free CRF and is a functional candidate gene for affective disorders.
|
17599466 |
2007 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The most robustly confirmed neuroendocrine finding among psychiatric patients with affective disorders is hyperactivity of the hypothalamic-pituitary-adrenocortical (HPA) system, resulting from hyperactive hypothalamic corticotropin-releasing hormone (CRH) neurons.
|
11337098 |
2001 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Dysfunctioning of corticotropin-releasing factor (CRF) and its receptors (CRF(1) and CRF(2)) has been linked to the development of stress-related disorders, such as affective disorders and drug abuse.
|
16611089 |
2006 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
These findings show that stress activates BNST CRF neurons, and that α<sub>2A</sub>-AR activation suppresses the <i>in vivo</i> activity of these cells, at least in part by suppressing excitatory drive from PBN inputs onto CRF neurons.<b>SIGNIFICANCE STATEMENT</b> Stress is a major variable contributing to mood disorders.
|
30478032 |
2019 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
These results indicate that the central CRF signal, rather than the peripheral CRF signal would be related to anxiety and other behavioral changes, and CRF<sub>1</sub> receptor antagonism in the central nervous system may be critical for identifying drug candidates for anxiety and mood disorders.
|
28689880 |
2017 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of affective disorders.
|
18475271 |
2008 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Our present findings give further evidence that the blockage of CRF action may be useful in the treatment of mood disorders.
|
28429110 |
2017 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Getting closer to affective disorders: the role of CRH receptor systems.
|
15310462 |
2004 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Corticotropin-releasing factor (CRF), its receptors, and signaling pathways that regulate CRF expression and responses are areas of intense investigation for new drugs to treat affective disorders.
|
17908177 |
2008 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Corticotropin-releasing factor-binding protein (CRF-BP) regulates the availability of free CRF and is a functional candidate gene for affective disorders.
|
17599466 |
2007 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
The ratio of the CRH-RAR-alpha double-staining neurons to the CRH-immunoreactive neurons in affective disorder patients was also increased.
|
19596122 |
2009 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders.
|
15899517 |
2005 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders.
|
17728670 |
2007 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression.
|
30499109 |
2019 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Given the fundamental role of the corticotropin-releasing hormone (CRH) system in anxiety, stress-associated pathologies, and mood disorders, we describe genetic modifications of the genes that encode proteins integral to the CRH/CRH receptor system with particular emphasis on conditional gene-targeting strategies.
|
14755129 |
2004 |
Mood Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Decades of research have described the importance of corticotropin-releasing factor (CRF) signaling in alcohol addiction, as well as in commonly co-expressed neuropsychiatric diseases, including anxiety and mood disorders.
|
30217435 |
2018 |
Mood Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The activation and expression of glucocorticoids and CRH are variable and may hold important clues to individual experiences of mood disorders.
|
28119322 |
2017 |