|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression.
|
29317606 |
2018 |
|
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
A retrospective cohort study, including children who underwent surgery due to CS (n = 115), was divided into children with a pituitary adenoma (Cushing disease) (n = 88), primary adrenal CS (n = 21), or ectopic adrenocorticotropin- or corticotropin-releasing hormone (ACTH-/CRH)-secreting tumors (n = 6).
|
28433999 |
2017 |
|
Cushing Syndrome
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We examined whether this relative hypercortisolism is associated with alterations in the pituitary-adrenocortical response to evening corticotropin-releasing hormone (CRH) stimulation.
|
28444400 |
2017 |
|
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
ACTH = adrenocorticotropic hormone; BIPSS = bilateral inferior petrosal sinus sampling; CBG = corticosteroid-binding globulin; CD = Cushing disease; CRH = corticotropin-releasing hormone; CS = Cushing syndrome; Dex = dexamethasone; DST = dexamethasone suppression test; EAS = ectopic ACTH syndrome; FDA = U.S. Food & Drug Administration; HDDST = high-dose DST; IPS/P = inferior petrosal sinus to peripheral; MRI = magnetic resonance imaging; NET = neuroendocrine tumor; PET = positron emission tomography; UFC = urinary free cortisol.
|
28614036 |
2017 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Preclinical studies have shown that dysregulation of the corticotropin releasing factor (CRF) neurotransmission has been implicated in stress-related psychopathologies such as depression and anxiety, and may affect alcohol consumption.
|
29118713 |
2017 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serotonin, norepinephrine, dopamine, and trace amines, such as the "endogenous amphetamine" phenylethylamine, are increased in brain, which leads to changes in neuroplasticity by e.g. increased neurotrophic growth factors and translates to reduced stress-induced hypersecretion of corticotropin releasing factor (CRF) and positive testing in animal studies of depression.
|
28655495 |
2017 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion has been associated with chronic states of anxiety and depression.
|
28500827 |
2017 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the augmented glutamatergic and synaptic signaling might be a potential mechanism underlying CRH over-activation in the hypothalamic PVN and contribute to CUS-induced depression-like behaviors in rats.
|
28735061 |
2017 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of our study was to assess the influence of SN003, a CRF<sub>1</sub> receptor blocker, on the activity of imipramine and fluoxetine in the forced swim test (FST) in rats which presented some signs of depression.
|
28429110 |
2017 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
i) Compared to control subjects, the amount of hypocretin-immunoreactivity (ir) was significantly increased in female but not in male depression patients; ii) hypothalamic hypocretin-ir showed a clear diurnal fluctuation, which was absent in depression; iii) male depressive patients who had committed suicide showed significantly increased ACC Hcrt-receptor-2-mRNA expression compared to male controls; and iv) female but not male CUMS rats showed a highly significant positive correlation between the mRNA levels of corticotropin-releasing hormone and prepro-hypocretin in the hypothalamus, and a significantly increased Hcrt-receptor-1-mRNA expression in the frontal cortex compared to female control rats.
|
28377228 |
2017 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Early life stress (ELS) is associated with increased vulnerability for depression, changes to the corticotropin-releasing hormone (CRH) system and structural and functional changes in hippocampus.
|
28461011 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serotonin, norepinephrine, dopamine, and trace amines, such as the "endogenous amphetamine" phenylethylamine, are increased in brain, which leads to changes in neuroplasticity by e.g. increased neurotrophic growth factors and translates to reduced stress-induced hypersecretion of corticotropin releasing factor (CRF) and positive testing in animal studies of depression.
|
28655495 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Preclinical studies have shown that dysregulation of the corticotropin releasing factor (CRF) neurotransmission has been implicated in stress-related psychopathologies such as depression and anxiety, and may affect alcohol consumption.
|
29118713 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the augmented glutamatergic and synaptic signaling might be a potential mechanism underlying CRH over-activation in the hypothalamic PVN and contribute to CUS-induced depression-like behaviors in rats.
|
28735061 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion has been associated with chronic states of anxiety and depression.
|
28500827 |
2017 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
i) Compared to control subjects, the amount of hypocretin-immunoreactivity (ir) was significantly increased in female but not in male depression patients; ii) hypothalamic hypocretin-ir showed a clear diurnal fluctuation, which was absent in depression; iii) male depressive patients who had committed suicide showed significantly increased ACC Hcrt-receptor-2-mRNA expression compared to male controls; and iv) female but not male CUMS rats showed a highly significant positive correlation between the mRNA levels of corticotropin-releasing hormone and prepro-hypocretin in the hypothalamus, and a significantly increased Hcrt-receptor-1-mRNA expression in the frontal cortex compared to female control rats.
|
28377228 |
2017 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Early life stress (ELS) is associated with increased vulnerability for depression, changes to the corticotropin-releasing hormone (CRH) system and structural and functional changes in hippocampus.
|
28461011 |
2017 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of our study was to assess the influence of SN003, a CRF<sub>1</sub> receptor blocker, on the activity of imipramine and fluoxetine in the forced swim test (FST) in rats which presented some signs of depression.
|
28429110 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
This paper explores the interactions of glucocorticoids and CRH in the presentation of anxiety and depressive disorders in an effort to better describe their differing roles in each of these clinical presentations.
|
28119322 |
2017 |
|
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
Endogenous Cushing syndrome (CS) in pediatrics is rare; it may be caused by tumors that produce corticotropin in the pituitary gland or elsewhere, tumors that produce corticotropin-releasing hormone anywhere, and adrenocortical masses that produce cortisol.
|
27241967 |
2016 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression.
|
27582123 |
2016 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression.
|
27582123 |
2016 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Correlation analysis indicated that the alteration of multiple CRF-controlling receptors is highly correlated with depression-related behaviors of rats in the forced swimming test.
|
25578258 |
2015 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Correlation analysis indicated that the alteration of multiple CRF-controlling receptors is highly correlated with depression-related behaviors of rats in the forced swimming test.
|
25578258 |
2015 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association analysis for corticotropin releasing hormone polymorphisms with the risk of major depressive disorder and the response to antidepressants.
|
26055202 |
2015 |