|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
We also found suggestive associations in women for GAD1, GRIA3, and BDNF with depression accompanied by fatigue, and for CRHR1 with depression accompanied by early morning awakenings.
|
19548263 |
2010 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Increasing evidence have indicated the strong association of stress, especially the chronic stress and early life stress, with depressive disorders development, while the association of stress with depression is moderated by genetic risk factors, including polymorphism of SERT, BDNF, GR, FKBP5, MR, and CRHR1.
|
31784962 |
2019 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis.
|
24933348 |
2015 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data support the corticotropin-releasing hormone hypothesis of depression and suggest that a gene x environment interaction is important for the expression of depressive symptoms in adults with CRHR1 risk or protective alleles who have a history of child abuse.
|
18250257 |
2008 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity.
|
24931706 |
2014 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To comprehensively map the genetic variation in CRHR1 in relation to suicidality and depression, as a follow-up to our initial report on SNP rs4792887, we analyzed six new single nucleotide polymorphisms (SNPs), in an extended sample of family trios (n = 672) with suicide attempter offspring, by using family-based association tests.
|
19220485 |
2009 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children.
|
25422957 |
2014 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to analyze the possible association of CRHR1 and AVPR1b gene variants with bipolar disorder and major depressive disorder (MDD).
|
23962971 |
2013 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Allelic association between CRHR1 rs242939 and recurrent MDD was found in our sample (allelic: p = 0.018, genotypic: p = 0.022) with an Odds Ratio 0.454 (95% CI 0.266-0.775).
|
22194899 |
2011 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In contrast, NR3C2, FKBP5 and CRHR1 polymorphisms were not significantly associated with MDD.
|
27549215 |
2017 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results support the idea that the CRHR1 gene is likely to be involved in the antidepressant response in MDD.
|
17258395 |
2007 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results provide support for an association of CRHR1 and CRHR2 with MDD and PD.
|
22467522 |
2012 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
A nonpeptide CRF1 receptor antagonist has also been shown to reduce symptoms of major depression in an open-label clinical trial.
|
16122764 |
2006 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
DNAm levels within CpG sites in NR3C1, CRH, CRHR1, and CRHR2 were associated with risk for MDD across adolescence and young adulthood.
|
31582756 |
2019 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results support the idea that the CRHR1 gene is likely to be involved in the genetic vulnerability for major depression.
|
16815632 |
2006 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
CRHR1 was genotyped in 83 controls and a preliminary sample of 16 unmedicated patients with MDD who completed a functional magnetic resonance imaging scan while viewing blocks of positive, negative, and neutral words.
|
22378896 |
2012 |
|
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Recent clinical and preclinical studies, using genetic screening and transgenic rodents, respectively, suggest a major role of the CRF1 gene, and the central expression of CRF1 receptor protein in determining an individual's risk of developing MDD.
|
26271720 |
2015 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results strengthen the evidence for the role of CRHR1 SNPs in MDD susceptibility and suggest that their effects may be modulated by sex and smoking status.
|
27544317 |
2016 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans.
|
19844206 |
2009 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD).
|
22249355 |
2013 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood.
|
23529111 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The complex structure of CRHR1 may help to explain why some variants in the gene moderate the effects of an ACE only on depression risk while others moderate the effect of an ACE only on AD risk.
|
21998007 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Association of CRHR1 and CRHBP genotypes with the following: (1) AUD; (2) a newly developed alcoholism severity score comprising 5 AUD-relevant variables; and (3) quantitative CRHR1 and CRHBP messenger RNA expression.
|
21810631 |
2011 |