|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IgM responses to NO-adducts and OSEs, especially malondialdehyde and myristic acid, and C-reactive protein (CRP) were inversely associated with TRYCAT pathway activity, whilst a lifetime depression and Pseudomonas putida were positively associated.
|
28600633 |
2017 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Relationships between CRP and KYNA with some hippocampal subfield volumes in MDD patients suggest that this inflammatory signature may be associated with reduced hippocampal subfield volumes in depression.
|
29787958 |
2018 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results indicated a cross-sectional and longitudinal association between both CRP and IL-6 with depression in older adults, with inflammation leading to depression in longitudinal studies rather than depression to inflammation.
|
29237576 |
2018 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The associations between baseline log CRP and depression response and remission were also assessed.
|
29654412 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mediation analysis found that lower CRP partially mediated less depression in EGFR mutant NSCLC.
|
31022775 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic analysis indicated that CRP had moderate predictive accuracy in identifying elevated depression (area under the curve = 0.74).
|
30521079 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
HOMA2IR and insulin were predicted by diagnosis (increased in MS), age and body mass index (BMI); AIP by diagnosis, sex, BMI, CRP, and uric acid; triglycerides by diagnosis (higher in MS without depression), age, BMI and uric acid; ferritin by diagnosis (higher in MS), sex, CRP, and albumin; and iron by albumin.
|
28152396 |
2017 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Higher baseline CRP levels were associated lower depression severity (correlation coefficient=-0.63) with bupropion-SSRI combination but not with SSRI monotherapy (correlation coefficient=0.40).The overall remission rate was 41.5%.
|
28187400 |
2017 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-6, CRP and triglycerides are likely to be causally linked with depression, so could be targets for treatment and prevention of depression.
|
30886334 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The prevalence of elevated CRP (>1 mg/L) in depression was 58% (95% CI 47-69%), and the meta-analytic odds ratio for elevated CRP in depression compared with controls was 1.47 (95% CI 1.18-1.82).
|
31258105 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically active cannabis users (CU) and non-users (NU).
|
31319037 |
2020 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate increased gut permeability (a "leaky gut") as one potential mechanistic pathway from marital distress and depression to heightened inflammation, this secondary analysis of a double-blind, randomized crossover study examined serial assessments of two endotoxin biomarkers, LPS-binding protein (LBP) and soluble CD14 (sCD14), as well as C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) during two separate 9.5 h visits.
|
30098513 |
2018 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Baseline median CRP differed significantly between mental disorders (P=0.01) being highest in individuals with bipolar disorder (3.5mg/L) (particularly during manic states, 3.9mg/L), followed by schizophrenia (3.1mg/L), and depression (2.8mg/L), while baseline WBC count did not differ (median 7.1×10<sup>9</sup>/L).
|
28645055 |
2017 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We aimed to investigate whether depression was associated with serum CRP levels in a cross-sectional analysis of a large cohort from a middle-income country.
|
27816325 |
2017 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings raise new evidence for the relationship between circulating CRP level and depression occurrence.
|
29340226 |
2017 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Higher CRP was not associated with depression, and it independently predicted mortality (OR = 1.92, p = 0.030).
|
27384414 |
2017 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
CRP and IL-6 were correlated with lower symptom scores of anxiety and depression prior or immediately after the headache period in patients groups.
|
31823093 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, C-reactive protein was not associated with current depression in cross-sectional and longitudinal analyses.
|
30819515 |
2019 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Depressive symptoms were associated with CRP levels, providing supporting evidence for the role of inflammation in the pathophysiology of depression.
|
30958417 |
2019 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Study participants are then assigned into one of two study strata: either into the 'Depression with inflammation' stratum (CRP levels > 3 mg/L); or into the 'Depression without inflammation' stratum (CRP levels ≤ 3 mg/L).
|
30126458 |
2018 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both positive affect and life satisfaction were significantly related to lower CRP even after controlling for demographics and depression, in both the overall sample and chronically ill group.
|
28701268 |
2018 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our finding may raise new evidence that genetically increased serum CRP level through SNPs variation is likely to induce family inherited depression.
|
30048584 |
2018 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Is the Relationship between Depression and C Reactive Protein Level Moderated by Social Support in Elderly?-Korean Social Life, Health, and Aging Project (KSHAP).
|
29422922 |
2018 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Fatigued bereaved individuals (33%; SF-36 energy/vitality score 0-45) had significantly higher CRP levels (p < .05) as compared to non-fatigued bereaved individuals and reported higher levels of pain (p < .001), greater stress (p < .001), depression (p < .001), and sleeping problems (p < .001), as well as poorer social functioning (p < .001) and general health (p < .001) than those in the non-fatigued group.
|
30097134 |
2018 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate the association between CRP and overall depression severity including specific depressive symptoms and to examine potential gender differences.
|
28257825 |
2017 |