Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically active cannabis users (CU) and non-users (NU).
|
31319037 |
2020 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
A complete clinical assessment, assessment of vascular risk factors, blood sample for the evaluation of serum CRP was obtained, and baseline depression severity was measured on Hamilton Depression Rating Scale (HDRS).
|
30581212 |
2020 |
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have examined whether longitudinal patterns of inflammation, based on three CRP measurements from childhood to early-adulthood, are associated with the risk of depression in early-adulthood in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort.
|
31707310 |
2020 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered.
|
30854996 |
2020 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The associations between baseline log CRP and depression response and remission were also assessed.
|
29654412 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mediation analysis found that lower CRP partially mediated less depression in EGFR mutant NSCLC.
|
31022775 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic analysis indicated that CRP had moderate predictive accuracy in identifying elevated depression (area under the curve = 0.74).
|
30521079 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-6, CRP and triglycerides are likely to be causally linked with depression, so could be targets for treatment and prevention of depression.
|
30886334 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The prevalence of elevated CRP (>1 mg/L) in depression was 58% (95% CI 47-69%), and the meta-analytic odds ratio for elevated CRP in depression compared with controls was 1.47 (95% CI 1.18-1.82).
|
31258105 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
CRP and IL-6 were correlated with lower symptom scores of anxiety and depression prior or immediately after the headache period in patients groups.
|
31823093 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, C-reactive protein was not associated with current depression in cross-sectional and longitudinal analyses.
|
30819515 |
2019 |
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Depressive symptoms were associated with CRP levels, providing supporting evidence for the role of inflammation in the pathophysiology of depression.
|
30958417 |
2019 |
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Controlling for inflammatory activity at BD1, depression at BD1, demographics and the time between assessments, increases in interleukin-6 (IL-6; b = 0.878, p = .007) and C-reactive protein (CRP; b = 0.252, p = .024) from BD1 to BD2 interacted with recent stressful life events before BD1 to predict severity of depressive symptoms at BD2.
|
30822466 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The depression sum-score was related to both IL-6 and CRP before, and only to IL-6 after covariate adjustment.
|
31615595 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total of 126 patients with PsA were included and the following variables were assessed: Tender joint count (TJC), swollen joint count (SJC), patient's global assessment, physician's global assessment, pain, extra-articular manifestations, Psoriasis Area and Severity Index, Health Assessment Questionnaire, fatigue, Short Form-36, psoriatic quality of life, Hospital Anxiety and Depression Scale and C-reactive protein (CRP).
|
30426235 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
When stratifying by zygosity, significant associations from IL-6 to depression were only seen in monozygotic twins, but associations from depression to CRP were more robust in dizygotic twins, which implies that genetic factors may play a role in this association.
|
30394311 |
2019 |
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CRP SNPs rs1800947 and rs2794521 may be associated with depressive symptoms in patients with depression in a sexspecific fashion.
|
31711279 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
In women, there was no association between CRP and telomere length, regardless of the depression status.
|
31109116 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
After additionally controlling for physical activity, elevated WBC count (p = 0.002) and decreased levels of urine cortisol (p = 0.05) remained significant predictors of PTSD course, and elevated WBC count (p = 0.001), CRP (p = 0.03), and fibrinogen (p = 0.02) remained significant predictors of depression course.
|
30389462 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
DPP participants randomized to metformin (MET), life-style intervention (ILS), or placebo (PLB) were assessed for depression (Beck Depression Inventory [BDI]) annually, ADM use semiannually, serum inflammatory markers (C-reactive protein [CRP], interleukin 6 [IL-6]) at baseline and year 1, and diagnosis of type 2 diabetes mellitus (T2DM) semiannually (for 3.2 years).
|
29016549 |
2019 |
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
After adjustment for demographics, health indicators, and medication use, increased plasma CRP levels were more strongly associated with late-onset depression than early-onset depression (OR [95% CI]: 1.43 [1.05-1.94]).
|
30172071 |
2019 |
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
One hundred and twenty outpatients with IBD were recruited and: (a) completed questionnaires to record: age, sex, social support, socioeconomic status, anxiety and depression (n = 104), (b) underwent assessments of biases in emotional recognition (n = 112), emotional memory and reinforcement learning (c) had recorded from clinical records: type of IBD, duration of IBD, IBD activity and (d) provided blood for high-sensitivity C-reactive protein levels (n = 99).
|
31267614 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
After adjusting for age, gender, BMI, smoking, and dyslipidemia-inducing antipsychotics, TC and LDL scores showed significant associations with depression [β = 0.13, p = 0.007; β = 0.14, p = 0.007], and with two inflammatory markers: CRP [β = 0.14, p = 0.007; β = 0.16, p = 0.007] and OPG [β = 0.14, p = 0.007; β = 0.11, p = 0.007].
|
29721726 |
2019 |
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inflammation is associated with depression, especially in women, and levels of C-reactive protein (CRP) and interleukin (IL)-6 predict response to antidepressant medications.
|
29489077 |
2019 |
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to examine the serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) in MDD patients to find out their association with depression.
|
30899619 |
2019 |