CRP, C-reactive protein, 1401

N. diseases: 1483; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE After beta-blocker treatment, hs-CRP levels are associated with functional capacity in HF patients. 29396658 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE Vaccine responsiveness was inversely related to the CRP level in elderly participants, but not seniors, and those with congestive heart failure were less likely to achieve a 2-fold response (odds ratio, 0.08). 28838148 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Further analysis revealed that MedDietScore differentially affected patients' prognosis according to heart failure phenotype, with short-term impact in HFrEF and HFmrEF patients yet longer positive outcomes in HFpEF and C-reactive protein potentially mediated these relations. 28832572 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE This study examined the individual and combined effect of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), interleukin-6 (IL-6), and hs-CRP on the prediction of heart failure incidence or progression in patients with type 2 diabetes. 28684396 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE C-reactive protein levels reached a peak after 48 h. Patients with STEMI and signs of HF showed significantly higher peak CRP levels. 28883850 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE After further adjustment for biomarkers (high-sensitivity C-reactive protein, lipoprotein-associated phospholipase A<sub>2</sub> activity, high-sensitivity troponin I, and B-type natriuretic peptide), IL-6 remained significantly associated with the risk of major adverse cardiovascular events (adj HR Q4:Q1 1.43, 95% CI 1.09-1.88) and cardiovascular death or heart failure (adj HR 1.79, 95% CI 1.22-2.63). 29066436 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE Female gender, history of heart failure or left ventricular ejection fraction <40%, and high levels (>1 mg/dL) of C-reactive protein (CRP) were independently associated with left atrial SEC/thrombosis. 27730663 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE To describe correlations and agreement between salivary and serum B-type natriuretic peptide (BNP), C-reactive protein (CRP), interleukin (IL)-6, and IL-10 and determine which biomarkers predict worse functional class in patients with heart failure (HF). 27605566 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE This study investigated the prospective influence of marital status, social support, depression, and C-reactive protein (CRP) on the mortality of patients with chronic HF. 27384414 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE We performed a cross-sectional analysis to investigate the relationships between inflammatory biomarkers [serum interleukin-6 (IL-6), C-reactive protein (hs-CRP) and serum amyloid A (SAA)] and median of 6 years follow-up for all-cause mortality and HF hospitalization among women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF. 28542263 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Presence of metabolic syndrome (MS) and its components, presence of heart failure, severity of CAD symptoms, severe past ventricular arrhythmia (sustained ventricular tachycardia [sVT] or ventricular fibrillation [VF]), lower left ventricle ejection fraction, higher left ventricle mass index, higher end-diastolic volume and higher number of smoking pack-years were significantly associated with higher WBC, CRP and IL-6. 26864064 2016
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Serum C-reactive protein (CRP) elevation is associated with poor clinical outcome in patients with heart failure (HF). 22875408 2013
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE After adjusting for traditional risk factors, high-sensitivity C-reactive protein, N-terminal pro-B-type natriuretic peptide, and high-sensitivity cardiac troponin T, higher levels of Cp were associated with HF (hazard ratio, 1.44; 95% confidence interval, 1.13-1.83) and mortality (hazard ratio, 1.38; 95% confidence interval, 1.11-1.63). 23861484 2013
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Serum C-reactive protein (CRP) elevation predicts the development of heart failure in patients with hypertension. 21220701 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE However, the effect of CRP on heart failure has not been elucidated. 21519150 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 GeneticVariation disease BEFREE The objective of the study was to determine whether GR haplotype 3 is associated with HF and whether this association is explained by low-grade inflammation (C-reactive protein). 20371666 2010
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE In this study we investigated distribution of CRP, the Terminal Complement Complex (C5b-9) and macrophages (CD68) in the myocardium of patients suffering from non-ischaemic heart failure and their implication on clinical parameters. 19343415 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 GeneticVariation disease BEFREE We collected conventional (blood pressure, cholesterol, adiposity), lifestyle, and novel (C-reactive protein, CRP) risk factors at baseline in participants from the Scottish Health Surveys (n = 5946, 44.5% men, aged 53.6 +/- 12.4 years), who were followed up over an average of 7.1 years for cardiovascular disease (CVD) events (a composite of fatal and nonfatal events incorporating acute myocardial infarction, coronary artery bypass surgery, percutaneous coronary angioplasty, stroke, heart failure). 19587606 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE In group 1, patients with a G/G genotype had significantly higher levels of high-sensitivity C-reactive protein and white blood cell counts, and much higher incidences of multi-vessel disease, greater lesion lengths, advanced congestive heart failure (>or=class 3) and 30-day mortality, than patients with G/A or A/A genotypes (p values<0.05 in all cases). 17652883 2007
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE The patient finally had a partial clinical response (reduction in fever and irritability) and complete laboratory response (improved C-reactive protein and serum amyloid A levels) to humanized anti-IL-6 receptor antibody (MRA), but died from congestive heart failure and interstitial pneumonia 2 months after initiation of therapy. 16802372 2006
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease CTD_human The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. 16360360 2005