CRP, C-reactive protein, 1401

N. diseases: 1483; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE However, despite low arterial lactate, patients with a high APACHEⅡ score, high C-reactive protein levels, and chronic heart failure had a poorer prognosis. 28923305 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Efficient electron-mediated electrochemical biosensor of gold wire for the rapid detection of C-reactive protein: A predictive strategy for heart failure. 31400725 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 GeneticVariation disease BEFREE Other predictors included ischemic etiology (HR 1.33, p=0.023), prior hospitalization for heart failure (HR 1.34, p=0.017), C-reactive protein (HR 1.04, p<0.001), and statin use (HR 0.70, p=0.016). 29169753 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE Our results hint towards an association of less common CRP genetic variants with increased mortality risk, depressive symptoms and peripheral CRP levels in this population of HF patients thereby suggesting a possible role of the inflammatory system as link between poor prognosis in HF and depressive symptoms. 29627531 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE The patient finally had a partial clinical response (reduction in fever and irritability) and complete laboratory response (improved C-reactive protein and serum amyloid A levels) to humanized anti-IL-6 receptor antibody (MRA), but died from congestive heart failure and interstitial pneumonia 2 months after initiation of therapy. 16802372 2006
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE Female gender, history of heart failure or left ventricular ejection fraction <40%, and high levels (>1 mg/dL) of C-reactive protein (CRP) were independently associated with left atrial SEC/thrombosis. 27730663 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE To describe correlations and agreement between salivary and serum B-type natriuretic peptide (BNP), C-reactive protein (CRP), interleukin (IL)-6, and IL-10 and determine which biomarkers predict worse functional class in patients with heart failure (HF). 27605566 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease CTD_human The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. 16360360 2005
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE As a result, previous studies have not provided conclusive evidence of the prognostic value of CRP for post-infarct LVSD or HF. 29633232 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE After multivariable adjustment for clinical variables and renal and CV biomarkers (estimated glomerular filtration rate, cystatin-C, urine albumin-to-creatinine ratio, FGF-23, high-sensitivity troponin T, N-terminal pro-B-type natriuretic peptide, and high-sensitivity C-reactive protein), low Klotho concentration remained strongly associated with increased risk of CV death or hospitalization for heart failure [adjusted hazard ratio (HR) 2.62; 95% confidence interval (CI) 1.35-5.08; P < 0.01]. 30773798 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE However, the effect of CRP on heart failure has not been elucidated. 21519150 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 GeneticVariation disease BEFREE We collected conventional (blood pressure, cholesterol, adiposity), lifestyle, and novel (C-reactive protein, CRP) risk factors at baseline in participants from the Scottish Health Surveys (n = 5946, 44.5% men, aged 53.6 +/- 12.4 years), who were followed up over an average of 7.1 years for cardiovascular disease (CVD) events (a composite of fatal and nonfatal events incorporating acute myocardial infarction, coronary artery bypass surgery, percutaneous coronary angioplasty, stroke, heart failure). 19587606 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE This study investigated the prospective influence of marital status, social support, depression, and C-reactive protein (CRP) on the mortality of patients with chronic HF. 27384414 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE Vitamin D supplementation in patients with CHF improved health-related quality of life and C-reactive protein levels [weighted mean difference (WMD): 6.75, 95% confidence interval (CI): 2.87 to 10.64, <i>p</i> < .001; standardised mean difference (SMD): -0.41, 95% CI: -0.71 to -0.11, <i>p</i> = .007]. 31032644 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE After adjusting for traditional risk factors, high-sensitivity C-reactive protein, N-terminal pro-B-type natriuretic peptide, and high-sensitivity cardiac troponin T, higher levels of Cp were associated with HF (hazard ratio, 1.44; 95% confidence interval, 1.13-1.83) and mortality (hazard ratio, 1.38; 95% confidence interval, 1.11-1.63). 23861484 2013
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE High CLA% was associated with significantly reduced risk of HF after adjustment for HF risk factors and C-reactive protein (hazard ratio [95% confidence interval], 0.64 [0.43-0.96]; quartile 4 versus quartile 1). 29306896 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE We performed a cross-sectional analysis to investigate the relationships between inflammatory biomarkers [serum interleukin-6 (IL-6), C-reactive protein (hs-CRP) and serum amyloid A (SAA)] and median of 6 years follow-up for all-cause mortality and HF hospitalization among women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF. 28542263 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE After multivariable adjustment for baseline clinical characteristics and established biomarkers (high-sensitivity troponin I, brain-type natriuretic peptide, and high-sensitivity C-reactive protein), FGF-23 concentration in the top quartile was independently associated with an increased risk of CV death or heart failure hospitalization (adjusted hazard ratio [HR], 2.35; 95% CI, 1.82-3.02; P < .001) and its individual components. 29710336 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE After beta-blocker treatment, hs-CRP levels are associated with functional capacity in HF patients. 29396658 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE We examined 2184 consecutive patients with previous MI and CRP data at baseline in the Chronic Heart Failure Registry and Analysis in the Tohoku district-2 (CHART-2) Study. 31358306 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 GeneticVariation disease BEFREE Furthermore, temporal changes in CRP levels were associated with cancer death in the overall cohort; HF patients with CRP ≥ 2.0 mg/L at both baseline and 1-year had significantly increased cancer death, while those with CRP ≥ 2.0 mg/L at baseline and < 2.0 mg/L at 1-year not. 31104823 2019