CST3, cystatin C, 1471

N. diseases: 370; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0264716
Disease: Chronic heart failure
Chronic heart failure
0.010 Biomarker disease BEFREE Relationship of High Circulating Cystatin C to Biochemical Markers of Bone Turnover and Bone Mineral Density in Elderly Males with a Chronic Heart Failure. 30820184 2019
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance
0.010 Biomarker phenotype BEFREE In the IGT group, the index which reflects the function of renal tubule-like N-acetyl-<i>β</i>-glucosaminidase, neutrophil gelatinase-associated lipocalin, retinol-binding protein, and cystatin C was higher than those in the control group and the NGT group (<i>P</i> < 0.05). 31737684 2019
Amputated structure (morphologic abnormality)
0.010 Biomarker phenotype BEFREE In a cohort study of non-traumatic amputation patients, eGFR based on creatinine and/or cystatin C were measured before and after amputation. 30646571 2019
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
Glaucoma, Primary Open Angle
0.010 AlteredExpression disease BEFREE We assume that elevated levels of OPN and cystatin C in POAG and PACG along with altered cathepsin levels may contribute to ECM aberration in glaucoma. 30994369 2019
CUI: C0521170
Disease: Osteoporotic Fractures
Osteoporotic Fractures
0.010 Biomarker group BEFREE We examined the relationships of cystatin C-based glomerular filtration rate (eGFRcys) and creatinine-based GFR (eGFRcr), as well as their ratio with occurrence of osteoporotic fracture in postmenopausal osteoporotic women. 29464358 2019
CUI: C0524909
Disease: Hepatitis B, Chronic
Hepatitis B, Chronic
0.010 AlteredExpression disease BEFREE We aimed to investigate the efficiency of cystatin C levels in predicting nephrotoxicity due to antiviral therapy in patients with chronic hepatitis B virus infection. 27753647 2019
CUI: C0750927
Disease: Apraxia, Developmental Verbal
Apraxia, Developmental Verbal
0.010 Biomarker disease BEFREE For example, inflammatory factors including C-reactive protein and cytokines, lipoprotein (a), and cystatin-C might be precipitating factor for CAS. 31637257 2019
CUI: C0751785
Disease: Unverricht-Lundborg Syndrome
Unverricht-Lundborg Syndrome
0.010 AlteredExpression disease BEFREE The expression profiles of CSTB and other candidate modifying genes, cathepsin B and cystatin C, were established by quantitative RT-PCR, and their respective transcription levels were compared with those from patients with a classic picture of ULD. 31368437 2019
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension
0.010 Biomarker phenotype BEFREE The levels of 24-h urine protein, homocysteine (Hcy), cystatin-C (Cys-C), serum creatinine (SCr), urea and β2 microglobulin in the pre-eclampsia groups were higher than those in the gestational hypertension group (P<0.05). 30651847 2019
Congenital urinary tract obstruction
0.010 Biomarker disease BEFREE This longitudinal, prospective study analyzed the first-year profile of two serum renal biomarkers: creatinine (sCr) and cystatin C (sCyC); and six urinary renal biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), transforming growth factor beta-1 (TGF-β1), retinol-binding protein (RBP), cystatin C (uCyC), and microalbuminuria (μALB) in a cohort of 37 infants with UTO divided into three subgroups: 14/37 with unilateral hydro(uretero)nephrosis, 13/37 with bilateral hydro(uretero)nephrosis, and 10/37 patients with lower urinary tract obstruction (LUTO), compared with 24 healthy infants matched by gestational age and birth weight. 30694385 2019
CUI: C1145628
Disease: Autonomic nervous system disorders
Autonomic nervous system disorders
0.010 Biomarker group BEFREE Therefore, the aim of this study was to investigate the relationship between CysC and cardiovascular autonomic dysfunction in type 2 diabetic patients without renal dysfunction. 31011584 2019
Acute disease of cardiovascular system
0.010 Biomarker group BEFREE The exposure variable used was eGFR level (CKD-EPI based on creatinine and cystatin C) with eGFR 60-89 mL/min/1.73 m<sup>2</sup> as a reference; the outcomes were mortality, acute cardiovascular disease, congestive heart failure, and rapid kidney function decline (RKFD; defined as a decline in eGFR by 3 mL/min/1.73 m<sup>2</sup> per year or more). 30560432 2019
Differentiated Thyroid Gland Carcinoma
0.010 Biomarker disease BEFREE Determination of effective half-life of <sup>131</sup>I in patients with differentiated thyroid carcinoma: comparison of cystatin C and creatinine-based estimation of renal function. 30382554 2019
CUI: C1609524
Disease: ADHF
ADHF
0.010 AlteredExpression disease BEFREE The impact of admission cystatin C levels on in-hospital and three-year mortality rates in acute decompensated heart failure. 30059128 2019
CUI: C2316786
Disease: Chronic kidney disease stage 2
Chronic kidney disease stage 2
0.010 GeneticVariation disease BEFREE Eight men with CKD stage 2 (cystatin C-based estimate of glomerular filtration rate: 60-89 ml/min/1.73 m<sup>2</sup>) participated in this study. 30729347 2019
Non ST segment elevation acute coronary syndrome
0.010 Biomarker disease BEFREE Here, we aimed to investigate the association of cystatin C with metabolic syndrome and cardiovascular outcomes in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) with preserved renal function. 31317040 2019
CUI: C3805043
Disease: Vascular cognitive impairment
Vascular cognitive impairment
0.010 AlteredExpression disease BEFREE It is probable that measurement of the serum cystatin C level and detection of CST3 gene polymorphism would aid in the early diagnosis of VCI, but further studies are warranted. 30805744 2019
CUI: C4087436
Disease: HIV viraemia
HIV viraemia
0.010 Biomarker disease BEFREE Correction: HIV Viremia and T-cell Activation Differentially Affect the Performance of Glomerular Filtration Rate Equations Based on Creatinine and Cystatin C. 30990858 2019
Large-artery atherosclerosis (embolus/thrombosis)
0.010 AlteredExpression disease BEFREE Additionally, cystatin C level was associated with different subtypes of ACI; large-artery atherosclerosis (LAA) subtype had the highest level of cystatin C in ACI and recurrent ACI group. 30033802 2019
CUI: C4721453
Disease: Peripheral Nervous System Diseases
Peripheral Nervous System Diseases
0.010 Biomarker group BEFREE Previous studies have proved that cystatin C (CysC) is an important predictor of both peripheral neuropathy and cardiovascular events. 31011584 2019
CUI: C0003578
Disease: Apnea
Apnea
0.010 AlteredExpression phenotype BEFREE Increased serum CysC levels in early PD patients were significantly associated with higher apnea and hypopnea index (AHI) (r = 0.231, P = 0.017), especially hypopnea index (r = 0.333, P < 0.001). 29664049 2018
CUI: C0004626
Disease: Pneumonia, Bacterial
Pneumonia, Bacterial
0.010 Biomarker group BEFREE Therefore, rCST9/rCSTC is a promising therapeutic candidate for the treatment of bacterial pneumonia. 29229643 2018
Malignant neoplasm of urinary bladder
0.010 Biomarker disease BEFREE Receiver operating characteristic (ROC) curve showed that BCa patients with cysC concentration <0.54 μg/ml [sensitivity: 87%; specificity: 92%; area under the curve (AUC) of ROC: 0.927; P=0.02] could be optimally separated from healthy people. 29749360 2018
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.010 Biomarker disease BEFREE Receiver operating characteristic (ROC) curve showed that BCa patients with cysC concentration <0.54 μg/ml [sensitivity: 87%; specificity: 92%; area under the curve (AUC) of ROC: 0.927; P=0.02] could be optimally separated from healthy people. 29749360 2018
CUI: C0005944
Disease: Metabolic Bone Disorder
Metabolic Bone Disorder
0.010 Biomarker group BEFREE A Study of the Relationship Between Cystatin C and Metabolic Bone Disease in Preterm Infants 29082894 2018