|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
We defined impaired kidney function as the cystatin C-based estimated glomerular filtration rate (eGFR<sub>cysC</sub>) < 60 ml/min/1.73 m<sup>2</sup>, and depressive symptoms as a score ≥ 5 on the 15-item Geriatric Depression Scale.
|
30400830 |
2018 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
We defined impaired kidney function as the cystatin C-based estimated glomerular filtration rate (eGFR<sub>cysC</sub>) < 60 ml/min/1.73 m<sup>2</sup>, and depressive symptoms as a score ≥ 5 on the 15-item Geriatric Depression Scale.
|
30400830 |
2018 |
|
Diabetic Retinopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After adjustment for confounding factors, the highest serum CysC level remained a significant risk factor for DR (odds ratio [OR], 1.929; 95% confidence interval [CI], 1.007 to 4.144; <i>P</i>=0.040).
|
30398035 |
2018 |
|
Down Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated whether CysC protects from trisomy-induced pathologies in a mouse model of Down syndrome (DS), the most common cause of developmental cognitive and behavioral impairments in humans.
|
30176349 |
2018 |
|
IGA Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multivariate linear regression analyses showed that serum levels of TNF-α were positively correlated with 24-h urine protein excretion (r = 0.33, P = 0.04), urinary protein to serum creatinine ratio (r = 0.33, P = 0.03), serum creatinine (r = 0.46, P < 0.0001) and Cystatin C (r = 0.59, P < 0.0001) in IgAN and negatively correlated with estimated glomerular filtration rate (r = - 0.49, P < 0.0001) after adjustment for sex, systolic blood pressure and diastolic blood pressure.
|
30428849 |
2018 |
|
Guillain-Barre Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The accuracy of cystatin C in the diagnosis of GBS was 0.827, sensitivity was 85.5%, and specificity was 89.7%.
|
29904402 |
2018 |
|
Leishmaniasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, uGGT and uGGT/uCR may be useful tools for early detection and assessment of renal lesions associated with leishmaniasis; however, cystatin C is useful for monitoring the progression of kidney disease when measured sequentially.
|
30069827 |
2018 |
|
Neuromyelitis Optica
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further studies on the role of CysC in NMOSD are warranted.
|
29603501 |
2018 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, <i>in vitro</i> studies showed that rCSTs (50 or 500 pg of each) directly decreased the viability of NDM-1 <i>K. pneumoniae</i> In conclusion, the data showed that rCST9/rCSTC worked synergistically to modulate host inflammation against MDR NDM-1 <i>K. pneumoniae</i> pneumonia, which significantly improved survival.
|
29229643 |
2018 |
|
Respiratory Distress Syndrome, Newborn
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum cystatin C as an early predictor of acute kidney injury in preterm neonates with respiratory distress syndrome.
|
29786454 |
2018 |
|
Respiratory Distress Syndrome, Adult
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum cystatin C as an early predictor of acute kidney injury in preterm neonates with respiratory distress syndrome.
|
29786454 |
2018 |
|
Sleep disturbances
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Then, we investigated the relationships between CysC and clinical variables and objective sleep disturbances in early PD patients.
|
29664049 |
2018 |
|
Small cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
The eGFR calculated by the CKD-EPI equation changed more significantly between each chemotherapy cycle than did the eGFR from the other equations based on Scr or CysC in patients with SCLC.
|
29103151 |
2018 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we propose that CST3 and GDF15 could be potential candidates for biopharmaceutics to ameliorate renal fibrosis.
|
29653105 |
2018 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
On the role of cystatin C in cancer progression.
|
29654808 |
2018 |
|
Metastatic malignant neoplasm to brain
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on these in vitro and in vivo experiments we hypothesize that CysC promotes melanoma brain metastasis.
|
29722001 |
2018 |
|
Chronic interstitial nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A comparison of cystatin C concentrations between patients with chronic interstitial nephritis and glomerular diseases.
|
28187233 |
2018 |
|
Parkinsonian Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Although Cystatin C (Cys C) and low-density cholesterol lipoprotein-C (LDL-C) are known to play critical roles in Parkinsonism, it is unknown whether they can be used as markers to distinguish PSP patients from healthy subjects and to determine disease severity.
|
29574085 |
2018 |
|
Viral myocarditis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Conversely, genetic deletion of cystatin C (Cstc-/-), which markedly enhanced CatB levels in hearts, distinctly increased the severity of VMC.
|
29360865 |
2018 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We defined impaired kidney function as the cystatin C-based estimated glomerular filtration rate (eGFR<sub>cysC</sub>) < 60 ml/min/1.73 m<sup>2</sup>, and depressive symptoms as a score ≥ 5 on the 15-item Geriatric Depression Scale.
|
30400830 |
2018 |
|
Arteriolar hyalinosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
GFR was assessed using new improved equation using serum creatinine and cystatin C. Sonar guided renal specimen was obtained and evaluated for the severity of global sclerosis (GS), segmental sclerosis (SS), tubular atrophy (TA), interstitial fibrosis (IF), arterial sclerosis (AS) and arteriolar hyalinosis (AH).
|
29193529 |
2018 |
|
hiv-infection/aids
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Statistically increased Cystatin-C levels were observed in HIV/AIDS patients with MetS (p = 0.017), when compared to patients without MetS.
|
29024496 |
2018 |
|
Carotid Atherosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Age, albuminuria, and GFR (estimated by the formula CKD-EPI using cystatin C) influenced the prevalence of carotid atherosclerosis.
|
30278805 |
2018 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic (ROC) curve showed that BCa patients with cysC concentration <0.54 μg/ml [sensitivity: 87%; specificity: 92%; area under the curve (AUC) of ROC: 0.927; P=0.02] could be optimally separated from healthy people.
|
29749360 |
2018 |
|
Sleep Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Then, we investigated the relationships between CysC and clinical variables and objective sleep disturbances in early PD patients.
|
29664049 |
2018 |