|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Through mounting genetic investigations, it has been established that IL12B and IL23R gene single nucleotide polymorphisms have significant associations with autoimmune diseases including inflammatory bowel disease, psoriasis, and ankylosing spondylitis.
|
28276258 |
2017 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
IL-23R single nucleotide polymorphisms (SNPs) have been shown to be associated with several autoimmune diseases, including Crohn's disease and rheumatoid arthritis, and Graves' ophthalmopathy (GO) in Caucasians.
|
19021011 |
2009 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
IL-23R single nucleotide polymorphisms (SNPs) have been associated with several autoimmune diseases, including Crohn's disease and rheumatoid arthritis.
|
18073300 |
2008 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Recent results have shown that the IL23R gene, coding for a subunit of the interleukin-23 receptor, is strongly associated with autoimmunity.
|
18199597 |
2008 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We investigated the association between systemic lupus erythematosus (SLE) and polymorphisms of interleukin-23 receptor (IL23R) gene, which was recently found to be associated with autoimmune diseases, including Crohn's disease, rheumatoid arthritis, psoriasis and ankylosing spondylitis.
|
19757086 |
2010 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of the interleukin-23 receptor (IL23R) gene have been found to play an important role in the development of several autoimmune diseases.
|
24332578 |
2014 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
STAT4 and IL23R loci represent common susceptibility genetic factors in autoimmunity.
|
24312163 |
2013 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Functional variants of the interleukin-23 receptor gene in non-gastrointestinal autoimmune diseases.
|
19747142 |
2009 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Interleukin-23 receptor (IL-23R) gene polymorphisms have been previously found to be associated with autoimmune diseases.
|
19317742 |
2009 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Present findings indicated that the autoimmune disease-associated genetic variants in IL-23R gene are not associated with RA in the Polish population.
|
29370888 |
2018 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis.
|
18082575 |
2007 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We confirmed the association of IL23R with psoriasis in a Hungarian population and demonstrated the effect of the rs11805303 SNP, which was tested so far only for other autoimmune diseases.
|
20978829 |
2011 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The subunit of IL-23 (IL12B) and its receptor (IL23R) gene single-nucleotide polymorphisms (SNPs) have been shown to be associated with several autoimmune diseases such as inflammatory bowel disease, psoriasis and ankylosing spondylitis.
|
24547735 |
2014 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Our results show that the R381Q IL23R variant leads to selective, potentially desirable, loss of function alterations in primary human CD4+ and CD8+ T cells, resulting in highly significant protection against autoimmunity.
|
21606346 |
2011 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In conclusion, we confirmed the susceptibility or protective associations of IL23R polymorphisms with AS in a Hungarian population and first demonstrated the involvement of the rs11805303 intronic single nucleotide polymorphisms, which was tested so far only for other autoimmune diseases.
|
19522770 |
2009 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of the interleukin-23 receptor (IL23R) gene have been found to play a role in the development of several autoimmune diseases.
|
23093364 |
2013 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Interleukin IL-23 receptor (IL-23R) is increasingly recognized as a key checkpoint in autoimmune diseases, including Hashimoto's thyroiditis (HT).
|
25863684 |
2015 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Interleukin-23 (IL-23)/IL-23 receptor (IL-23R) is essential for Th17 cell-mediated immune response, involved in autoimmune diseases and cancer pathogenesis.
|
21484795 |
2012 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
We observed that the loci shared among the most ADs include IL23R, OLIG3/TNFAIP3, and IL2RA.
|
22174698 |
2011 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Based on their respective associations with the IL-12 genes, autoimmune diseases appear to cluster in two groups that either show strong associations with the Th1/Th17 pathway (as indicated by genetic association with IL12B and IL23R) or the Th1/IL-35 pathway as the consequence of their association with polymorphisms in the IL12A gene region.
|
22819329 |
2012 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Allelic variants of p19 subunit of IL-23 (IL23A) and IL-23 receptor (IL23R) genes and increased IL-23 serum concentrations were associated with autoimmune diseases.
|
23579029 |
2013 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
We investigated the possible association of IL23R with systemic sclerosis (SSc), an autoimmune disease that leads to the development of cutaneous and visceral fibrosis.
|
19918037 |
2009 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
We examine recent progress made in the clarification of the functional mechanisms by which polymorphisms in the genes coding for interleukin-2 receptor alpha (IL2RA), IL7R, and IL23R may alter risk for autoimmune disease, and discuss opposite autoimmune risk alleles found, among others, at the IL10 locus.
|
22191464 |
2012 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
IL-23 binds IL-23R on the surface of target cells and transmits signals through Janus kinase 2/signal transducer and activator of transcription channels, participating in the occurrence of chronic inflammatory diseases and autoimmune diseases.
|
30328797 |
2018 |