IL23R, interleukin 23 receptor, 149233

N. diseases: 306; N. variants: 49
Disease: Autoimmune Diseases ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11580078
rs11580078
Entrez Id: 149233;400757
Gene Symbol: IL23R;C1orf141
IL23R;C1orf141
CUI: C0004364
Disease:
Autoimmune Diseases 		G 0.700 GeneticVariation GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
dbSNP: rs11209026
rs11209026
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
CUI: C0004364
Disease:
Autoimmune Diseases 		0.020 GeneticVariation BEFREE This data provides an explanation for the protective role of R381Q in CD and may lead to the development of improved therapeutics for autoimmune disorders like CD. 22022372 2011
dbSNP: rs11209026
rs11209026
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
CUI: C0004364
Disease:
Autoimmune Diseases 		0.020 GeneticVariation BEFREE Our results show that the R381Q IL23R variant leads to selective, potentially desirable, loss of function alterations in primary human CD4+ and CD8+ T cells, resulting in highly significant protection against autoimmunity. 21606346 2011
dbSNP: rs11805303
rs11805303
Entrez Id: 149233;400757
Gene Symbol: IL23R;C1orf141
IL23R;C1orf141
CUI: C0004364
Disease:
Autoimmune Diseases 		0.010 GeneticVariation BEFREE In conclusion, we confirmed the susceptibility or protective associations of IL23R polymorphisms with AS in a Hungarian population and first demonstrated the involvement of the rs11805303 intronic single nucleotide polymorphisms, which was tested so far only for other autoimmune diseases. 19522770 2009