|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In comparison to disease-matched controls, patients with CD developing psoriasis following IFX therapy were more likely to be homozygous for specific polymorphisms in the IL-23R gene (rs10489628, rs10789229, and rs1343151).
|
23274341 |
2013 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Three risk loci shared with ankylosing spondylitis and psoriasis (the MHC class I region, ERAP1 and IL23R and the MHC class I-ERAP1 interaction), as well as two loci shared with inflammatory bowel disease (IL23R and IL10) implicate shared pathogenic pathways in the spondyloarthritides and Behçet's disease.
|
23291587 |
2013 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We and others have shown that the minor, nonconserved allele Gln381 of the Arg381Gln single-nucleotide polymorphism (rs11209026G>A) of the IL-23 receptor gene (IL23R) protects against psoriasis.
|
23563201 |
2013 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
To study the association of single nucleotide polymorphisms (SNPs) of the TNF-α promoter and IL12B/IL23R genes with the response to anti-TNF-α in patients with psoriasis.
|
23662788 |
2013 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Paediatric-onset psoriasis showed a significant association with single nucleotide polymorphisms in the ERAP1 (P = 0.042) and IL23R loci (P = 0.042), LCE3C_LCE3B-del (P = 0.003) and HLA-C*06 (P = 1.72 × 10(-19)) when compared with the control group.
|
22512642 |
2012 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
AS is associated with the same polymorphisms of IL-23R as those linked to psoriasis and inflammatory bowel disease.
|
22782541 |
2012 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
We identified seven susceptibility loci outside the human leukocyte antigen region (9p24 near JAK2, 10q22 at ZMIZ1, 11q13 near PRDX5, 16p13 near SOCS1, 17q21 at STAT3, 19p13 near FUT2, and 22q11 at YDJC) shared between PS and CD with genome-wide significance (p < 5 × 10(-8)) and confirmed four already established PS and CD risk loci (IL23R, IL12B, REL, and TYK2).
|
22482804 |
2012 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate a significant association between IL23R gene polymorphisms and psoriasis/PsA.
|
22706445 |
2012 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWAS) in several populations have demonstrated significant association of the IL23R gene with IBD (Crohn's disease (CD) and ulcerative colitis (UC)) and psoriasis, suggesting that perturbation of the IL-23 signaling pathway is relevant to the pathophysiology of these diseases.
|
22022372 |
2011 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the association of IL23R with psoriasis in a Hungarian population and demonstrated the effect of the rs11805303 SNP, which was tested so far only for other autoimmune diseases.
|
20978829 |
2011 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankylosing spondylitis.
|
21364948 |
2011 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Psoriasis and psoriatic arthritis fall into this disease spectrum, with the largest region of susceptibility coming from the MHC (most likely HLA-C, ie, C*06:02 although additional influences are also being implicated), and most of the other genetic susceptibility coming from genes involved in cytokine production, specifically genes in the Th17 pathway (IL-12B, IL-23A and IL-23R, the latter, like in AS, not seen in Asians), genes in the nuclear factor κB pathway (TNFAIP3 and TNIP1) and genes in the Th2 pathway (IL-4 and IL-13).
|
21339218 |
2011 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
A recent genome-wide association analysis of psoriasis identified IL12B and IL23R as significantly associated with psoriasis.
|
19705136 |
2010 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study confirms the effects of IL-12B and IL-23R variants on psoriasis in East Asian populations, and provides a reference point for further investigation of the role of the IL-12/IL-23 pathway in chronic epithelial inflammation in Asian and other ethnic populations.
|
20875477 |
2010 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
|
20953187 |
2010 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, the results of multiple well-powered genome-wide association studies have identified several additional loci outside the major histocompatibility complex region associated with psoriasis risk, including three genes involved in interleukin (IL)-23 signaling (IL-23R, IL-23A, IL-12B), two genes that regulate nuclear factor-kappaB signaling (TNIP1, TNFAIP3), and two genes involved in the modulation of T-helper type 2 immune responses (IL-4, IL-13).
|
20480402 |
2010 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Variants in or near genes that encode subunits of cytokines (IL12B, IL23A) or cytokine receptors (IL23R) are interesting given that the gene product of IL12B, p40, is the target of a recently approved monoclonal antibody therapy for psoriasis (ustekinumab).
|
20415816 |
2010 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four variants of the IL12B and IL23R genes were analyzed in 1,114 PV patients, 748 patients with psoriatic arthritis (PA) and 937 healthy controls before and after stratification for the major psoriasis risk allele at psoriasis susceptibility locus 1 (PSORS1).
|
18800148 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
It is also the first study to report linkage and association of the IL23R region with psoriasis in the Finnish population.
|
19175939 |
2009 |