|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Predisposition to psoriasis is known to be affected by genetic variation in HLA-C, IL12B, and IL23R, and although other psoriasis-associated variants have been identified, incontrovertible statistical evidence for these markers has not yet been obtained.
|
18923449 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The rare allele of a non-synonymous interleukin 23 receptor (IL23R) single nucleotide polymorphism (SNP) rs11209026 (p.Arg381Gln) confers strong protection against Crohn disease (CD) and psoriasis.
|
18647855 |
2009 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The IL23R findings and subsequent immunological investigations suggest that targeted intervention in the TH17 system is likely to have major therapeutic benefit, as it does in the genetically related diseases, inflammatory bowel disease and psoriasis.
|
19496308 |
2009 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The magnitude of effect of IL-23R association in PsA appears to be similar to that reported in uncomplicated psoriasis.
|
19040306 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It is also the first study to report linkage and association of the IL23R region with psoriasis in the Finnish population.
|
19175939 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the UK case-control study with new cases, four of the eight SNPs showed significant associations, whereas in the extended UK study, seven of the eight IL-23R SNPs showed significant associations (P < 0.05) with AS, maximal with rs11209032 (P < 10(-5), OR 1.3), when cases with IBD and/or psoriasis were excluded.
|
19189980 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms in the IL-12beta and IL-23R genes are associated with psoriasis of early onset in a UK cohort.
|
18034172 |
2008 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Predisposition to psoriasis is known to be affected by genetic variation in HLA-C, IL12B and IL23R, but other genetic risk factors also exist.
|
18614543 |
2008 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The characterization of association patterns within IL23R to specific predisposing/protective variants will play an important role in the elucidation of psoriasis etiology and other related phenotypes.
|
18650833 |
2008 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results confirm associations between IL12B and IL23R and psoriasis in Caucasians, and provide a genetic basis for the clinical association between psoriasis and Crohn's disease.
|
18219280 |
2008 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The characterization of association patterns within IL23R to specific predisposing/protective variants will play an important role in the elucidation of psoriasis etiology and other related phenotypes.
|
18650833 |
2008 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
This concurrent analysis of 3 distinct AS populations and their regional controls demonstrates a disease association with the IL-23R locus and implicates the same polymorphisms associated with IBD and psoriasis.
|
18383363 |
2008 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Our results confirm associations between IL12B and IL23R and psoriasis in Caucasians, and provide a genetic basis for the clinical association between psoriasis and Crohn's disease.
|
18219280 |
2008 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We replicated the previously reported association with interleukin 23 receptor and interleukin 12B (IL12B) polymorphisms in PS and PSA cohorts (IL23R: rs11209026, U.S. PS, P = 1.4x10(-4); U.K. PSA: P = 8.0x10(-4); IL12B:rs6887695, U.S. PS, P = 5x10(-5) and U.K. PSA, P = 1.3x10(-3)) and detected an independent association in the IL23R region with a SNP 4 kb upstream from IL12RB2 (P = 0.001).
|
18369459 |
2008 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This concurrent analysis of 3 distinct AS populations and their regional controls demonstrates a disease association with the IL-23R locus and implicates the same polymorphisms associated with IBD and psoriasis.
|
18383363 |
2008 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Variation within IL23R and IL12B is associated with susceptibility to both psoriasis and PsA.
|
19035472 |
2008 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Haplotype analyses identified two IL23R missense SNPs that together mark a common psoriasis-associated haplotype in all three studies (OR(common) 1.44, Pcomb=3.13x10(-6)).
|
17236132 |
2007 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the association between systemic lupus erythematosus (SLE) and polymorphisms in the interleukin-23 receptor (IL23R) gene, which have been previously found to be associated with two autoimmune diseases: inflammatory bowel disease and psoriasis.
|
17661912 |
2007 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.
|
17587057 |
2007 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.
|
17587057 |
2007 |