|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CYP1A2 -3860G>A polymorphism modifies the smoking-related HCC risk among CLD patients.
|
19643819 |
2009 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No significant association between CYP1A2 genetic polymorphisms and HCC risk was observed in either HBsAg seropositive individuals or non-smokers.
|
16495781 |
2006 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since Qidong is a special region with particularly high incidence of hepatocellular carcinoma in China, the association of phenotypes with genotypes of CYP1A2 in the Qidong population might result from some inducible environmental factors such as those of cigarettes in smokers.
|
11470995 |
2001 |
|
Porphyria Cutanea Tarda
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
The CYP1A2*1F promoter A allele frequency was significantly higher (P < 0.022) and the A/A genotype frequency marginally higher in PCT patients overall (P < 0.057), with the A/A genotype significantly more common in type 1 PCT (P < 0.043).
|
20957336 |
2011 |
|
Porphyria Cutanea Tarda
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
We found an increase in the frequency of CYP1A2 g-163A allele in patients with PCT when compared with controls, although the more inducible A/A genotype had no effect on the onset age.
|
20163457 |
2010 |
|
Porphyria Cutanea Tarda
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Association of CYP1A2 polymorphisms with susceptibility to both types of PCT has already been described in Danish patients.
|
14714565 |
2003 |
|
Porphyria Cutanea Tarda
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
In this study, we have examined a group of Danish patients with PCT for the presence of the C/A polymorphism in intron 1 of CYP1A2.
|
11153915 |
2000 |
|
Squamous cell carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
There was however no significant increased risk of developing lung SCC in smokers having CYP1A2 gene polymorphisms.
|
19332078 |
2009 |
|
Squamous cell carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Our data also revealed that smokers or tobacco chewers carrying variant alleles of either CYP1A2*1D or CYP1A2*1F were at increased risk to SCC of lung, further demonstrating that CYP1A2 genotypes interact with environmental risk factors in enhancing the risk to squamous cell lung carcinoma.
|
22072123 |
2012 |
|
Squamous cell carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
A significant interaction between CYP1A2-T/delT or delT/delT genotypes and tobacco consumption (pack-years) adjusted for age was evident (OR (95% CI) 7.78 (1.52-42.8)) in the SCC cases who smoked relatively less (< or =33 pack-years, I quartile value), but not in adenocarcinoma and controls.
|
17509724 |
2007 |
|
Chronic Obstructive Airway Disease
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD.
|
20080081 |
2010 |
|
Chronic Obstructive Airway Disease
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data suggest that genetic alterations in CYP1A2 may play a role both in the pharmacogenetics of TP and in the development of COPD.
|
20797314 |
2010 |
|
Chronic Obstructive Airway Disease
|
0.330 |
GeneticVariation
|
disease |
LHGDN |
The (-2467)delT allele and CYP1A2*1D haplotype of CYPIA2 gene was associated with higher risk of COPD in Tatar ethnic group (OR = 1.83, 95% CI 1.24-2.71, chi2 = 9.48, p = 0.003 and chi2 = 9.733, p = 0.0027, Pcor = 0.008; OR = 3.908, 95% CI 1.56-10.19, respectively).
|
18389617 |
2008 |
|
Colorectal Neoplasms
|
0.320 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.
|
17615053 |
2007 |
|
Lung Neoplasms
|
0.320 |
GeneticVariation
|
group |
LHGDN |
NAT2 and CYP1A2 polymorphisms and lung cancer risk in relation to smoking status.
|
17477782 |
2007 |
|
Schizophrenia and related disorders
|
0.310 |
GeneticVariation
|
group |
BEFREE |
In this study we explored possible epistasis between CYP2D6 (*3, *4, *5, *6 and *1xN), CYP3A5 (*3), CYP1A2 (*1C and *1F) and ABCB1 (G2677T) in schizophrenia and related disorders.
|
21142916 |
2010 |
|
Drug-Induced Liver Disease
|
0.310 |
GeneticVariation
|
phenotype |
BEFREE |
The frequency of the CYP1A2 1F allele was 63.9% in P. multiflorum-induced DILI patients, compared to 57.0% in healthy controls; the difference was not significant.
|
25117321 |
2014 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that variation in the genes that metabolize tobacco carcinogens contribute to bladder cancer, we examined the effects of single nucleotide polymorphisms in the genes of four key enzymes: cytochrome P450 1A2, N-acetyltransferase (NAT) 2, sulfotransferase 1A1, and UDP-glucuronosyltransferase (UGT) 2B7.
|
22961351 |
2013 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the CYP1A2-163C/A polymorphism is associated with increased susceptibility to bladder cancer in the Chinese population.
|
27173252 |
2016 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India.
|
18200441 |
2008 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subjects possessing the NAT2 slow acetylation phenotype and the highest tertile of CYP1A2 scores showed the highest risk for bladder cancer.
|
21480221 |
2012 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Within the framework of a hospital-based case/control study, we investigated the relationship between CYP1A2 polymorphisms, occupational/environmental exposures and bladder cancer (BC) risk.
|
20559687 |
2010 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In summary, this meta-analysis suggests that CYP1A2*1F polymorphism is associated with lung cancer and bladder cancer risk in Caucasians.
|
25472037 |
2015 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, a C/A-polymorphism in intron 1 of cytochrome P450 1A2 was associated with high inducibility and persons with this high inducibility variant were overrepresented in bladder cancer, but only if they were smokers or if they had slow NAT2 genotypes.
|
10022251 |
1998 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results from the meta-analysis suggested that the CYP1A2 rs762551 polymorphism is a protective factor for bladder cancer, especially in Caucasians.
|
26514519 |
2015 |