Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE The present meta-analysis demonstrated that the poor metabolizer phenotype of CYP2D6 confers a significant genetic susceptibility to PD in Caucasians, especially in British white subjects. 24211060 2014
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE CYP2D6*4 allele polymorphism increases the risk of Parkinson's disease: evidence from meta-analysis. 24376807 2014
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease. 23258538 2013
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients. 21958961 2012
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 AlteredExpression disease BEFREE These data further support a possible role for CYP2D6 in neuroprotection from Parkinson's disease-causing neurotoxins, especially in the human brain where expression of CYP2D6 is high in some regions (e.g. substantia nigra). 20345925 2010
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Association of polymorphism in cytochrome P450 2D6 and N-acetyltransferase-2 with Parkinson's disease. 20364044 2010
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Multivariate logistic regression analysis revealed that heterozygous genotypes of cytochrome P4502D6*4(CYP2D6*4), CYP2E1*5B (RsaI) polymorphism and homozygous mutant genotypes of CYP2E1*6 (Dra1) were found to be overrepresented in PD cases when compared to the controls. 18327668 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands. 18300942 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE No significant association was found between CYP2D6 genotype and PD, but subjects with extensive metabolizer (EM) CYP2D6 phenotype, and the variant GSTP1*B genotype were at significantly higher PD risk than the corresponding poor or intermediary metabolizers (CYP2D6 poor metabolizer phenotype+intermediary metabolizers). 17250723 2007
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE We also found that the cytochrome P450 2D6 gene could have a modifying effect on the risk of PD among persons exposed to pesticides. 17502288 2007
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease. 17270484 2007
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE Our data illustrate, using CYP2D6 as an exemplar, that it is crucial to consider both genetic and environmental factors, and their interactions, in any examination of risk factors for PD. 17017524 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Allelic variation at the CYP2D6 gene has been suggested to be associated with CNS disorders, including Parkinson's disease and Lewy body dementia. 16337409 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Meanwhile, epidemiological studies from China have shown that the prevalence of PD is much lower than in the Caucasian population, explained by the low frequency of cytochrome P-450 CYP2D6 debrisoquine hydroxylase gene polymorphism. 15829184 2005
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease. 14991823 2004
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Interaction between GSTM1-null and CYP2D6-deficient alleles in the pathogenesis of Parkinson's disease. 15061826 2004
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease CTD_human We performed a case-control study of Parkinson's disease (PD) in a population characterized by a high prevalence of pesticide exposure and studied the joint effect of pesticide exposure and CYP2D6. 14991823 2004
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease CTD_human Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease. 15174030 2004
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease CTD_human Although they are based on a small group of subjects with the joint exposure, our findings are consistent with a gene-environment interaction disease model according to which (1) pesticides have a modest effect in subjects who are not CYP2D6 poor metabolizers, (2) pesticides' effect is increased in poor metabolizers (approximately twofold), and (3) poor metabolizers are not at increased PD risk in the absence of pesticide exposure. 14991823 2004
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Parkinson's disease and CYP2D6 polymorphism in Asian populations: A meta-analysis. 14557687 2003
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 AlteredExpression disease BEFREE Polymorphic activities of debrisoquine 4-hydroxylase were suggested to be associated with some complex diseases, such as cancer and Parkinson's disease. 11702057 2002
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE CYP2D6*4 polymorphism is not associated with Parkinson's disease and has no protective role against Alzheimer's disease in the Korean population. 11442888 2001
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE Genotyping of CYP2D6 in Parkinson's disease. 11097352 2001
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE CYP2D6 polymorphism in Parkinson's disease: the Rotterdam Study. 11295783 2001
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE We investigated the association of Parkinson's disease (PD) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (CYP2D6) and N-acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). 10928584 2001