|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present meta-analysis demonstrated that the poor metabolizer phenotype of CYP2D6 confers a significant genetic susceptibility to PD in Caucasians, especially in British white subjects.
|
24211060 |
2014 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CYP2D6*4 allele polymorphism increases the risk of Parkinson's disease: evidence from meta-analysis.
|
24376807 |
2014 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
|
23258538 |
2013 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.
|
21958961 |
2012 |
|
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These data further support a possible role for CYP2D6 in neuroprotection from Parkinson's disease-causing neurotoxins, especially in the human brain where expression of CYP2D6 is high in some regions (e.g. substantia nigra).
|
20345925 |
2010 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphism in cytochrome P450 2D6 and N-acetyltransferase-2 with Parkinson's disease.
|
20364044 |
2010 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multivariate logistic regression analysis revealed that heterozygous genotypes of cytochrome P4502D6*4(CYP2D6*4), CYP2E1*5B (RsaI) polymorphism and homozygous mutant genotypes of CYP2E1*6 (Dra1) were found to be overrepresented in PD cases when compared to the controls.
|
18327668 |
2008 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands.
|
18300942 |
2008 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No significant association was found between CYP2D6 genotype and PD, but subjects with extensive metabolizer (EM) CYP2D6 phenotype, and the variant GSTP1*B genotype were at significantly higher PD risk than the corresponding poor or intermediary metabolizers (CYP2D6 poor metabolizer phenotype+intermediary metabolizers).
|
17250723 |
2007 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We also found that the cytochrome P450 2D6 gene could have a modifying effect on the risk of PD among persons exposed to pesticides.
|
17502288 |
2007 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease.
|
17270484 |
2007 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data illustrate, using CYP2D6 as an exemplar, that it is crucial to consider both genetic and environmental factors, and their interactions, in any examination of risk factors for PD.
|
17017524 |
2006 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Allelic variation at the CYP2D6 gene has been suggested to be associated with CNS disorders, including Parkinson's disease and Lewy body dementia.
|
16337409 |
2006 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Meanwhile, epidemiological studies from China have shown that the prevalence of PD is much lower than in the Caucasian population, explained by the low frequency of cytochrome P-450 CYP2D6 debrisoquine hydroxylase gene polymorphism.
|
15829184 |
2005 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease.
|
14991823 |
2004 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interaction between GSTM1-null and CYP2D6-deficient alleles in the pathogenesis of Parkinson's disease.
|
15061826 |
2004 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
We performed a case-control study of Parkinson's disease (PD) in a population characterized by a high prevalence of pesticide exposure and studied the joint effect of pesticide exposure and CYP2D6.
|
14991823 |
2004 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease.
|
15174030 |
2004 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Although they are based on a small group of subjects with the joint exposure, our findings are consistent with a gene-environment interaction disease model according to which (1) pesticides have a modest effect in subjects who are not CYP2D6 poor metabolizers, (2) pesticides' effect is increased in poor metabolizers (approximately twofold), and (3) poor metabolizers are not at increased PD risk in the absence of pesticide exposure.
|
14991823 |
2004 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Parkinson's disease and CYP2D6 polymorphism in Asian populations: A meta-analysis.
|
14557687 |
2003 |
|
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Polymorphic activities of debrisoquine 4-hydroxylase were suggested to be associated with some complex diseases, such as cancer and Parkinson's disease.
|
11702057 |
2002 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CYP2D6*4 polymorphism is not associated with Parkinson's disease and has no protective role against Alzheimer's disease in the Korean population.
|
11442888 |
2001 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genotyping of CYP2D6 in Parkinson's disease.
|
11097352 |
2001 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CYP2D6 polymorphism in Parkinson's disease: the Rotterdam Study.
|
11295783 |
2001 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of Parkinson's disease (PD) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (CYP2D6) and N-acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE).
|
10928584 |
2001 |