NKX2-3, NK2 homeobox 3, 159296

N. diseases: 22; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis. 18500230 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 Biomarker disease CTD_human Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease LHGDN Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 Biomarker disease CTD_human We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. 18438406 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 Biomarker disease BEFREE We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. 18438406 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 Biomarker disease CTD_human We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. 18438406 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease BEFREE By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis. 18500230 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease LHGDN Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 Biomarker disease CTD_human Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. 17554261 2007
CUI: C0156147
Disease: Crohn's disease of large bowel
Crohn's disease of large bowel 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0156147
Disease: Crohn's disease of large bowel
Crohn's disease of large bowel 		0.300 Biomarker disease CTD_human Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 18438406 2008
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum 		0.300 Biomarker disease CTD_human Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 18438406 2008
CUI: C0678202
Disease: Regional enteritis
Regional enteritis 		0.300 Biomarker disease CTD_human Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 18438406 2008
CUI: C0678202
Disease: Regional enteritis
Regional enteritis 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0949272
Disease: IIeocolitis
IIeocolitis 		0.300 Biomarker disease CTD_human Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 18438406 2008
CUI: C0949272
Disease: IIeocolitis
IIeocolitis 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0156147
Disease: Crohn's disease of large bowel
Crohn's disease of large bowel 		0.300 Biomarker disease CTD_human Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. 17554261 2007
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum 		0.300 Biomarker disease CTD_human Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. 17554261 2007
CUI: C0678202
Disease: Regional enteritis
Regional enteritis 		0.300 Biomarker disease CTD_human Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. 17554261 2007
CUI: C0949272
Disease: IIeocolitis
IIeocolitis 		0.300 Biomarker disease CTD_human Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. 17554261 2007
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.090 AlteredExpression group BEFREE Nkx2-3 as a transcriptional regulator of MAdCAM-1 controls vascular patterning in visceral lymphoid tissues in mice, and has been identified as a susceptibility factor for inflammatory bowel diseases in humans, associated with lymphoid neogenesis in the inflamed intestines. 30891037 2019
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.090 GeneticVariation group BEFREE Contribution of NKX2-3 polymorphisms to inflammatory bowel diseases: a meta-analysis of 35358 subjects. 24473197 2014