ACE, angiotensin I converting enzyme, 1636

N. diseases: 1082; N. variants: 82
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0266200
Disease: Microcolon
Microcolon
0.010 GeneticVariation disease BEFREE We report three patients from two unrelated families with RTD due to pathogenic variants of the angiotensin-converting enzyme (ACE) gene, in whom RTD was associated with microcolon. 30071301 2019
CUI: C0267797
Disease: Acute hepatitis
Acute hepatitis
0.010 Biomarker disease BEFREE These findings support the view that the ACE inhibitory peptide alleviated acute hepatitis by down-regulating the ACE-AngII-AT<sub>1</sub> R axis, broadening the research approach to prevent acute hepatitis, and providing experimental data for the development and utilization of cashews.© 2019 Society of Chemical Industry. 31385307 2019
CUI: C0268095
Disease: Keshan disease
Keshan disease
0.010 Biomarker disease BEFREE Our ten-year follow-up analysis indicated that selenium supplementation, specifically combined with the use of angiotensin-converting enzyme inhibitor and beta blocker therapy, improved the survival of patients with chronic Keshan disease with congestive heart failure. 31016516 2019
Exudative age-related macular degeneration
0.010 Biomarker disease BEFREE Patients on BB versus angiotensin-converting enzyme/angiotensin receptor blocker at all time points and BB versus CCB and diuretics at 365 days did not have a significantly lower association with nAMD (HR: 0.73-0.85; P > 0.06 for all comparisons). 29394237 2019
Respiratory failure without hypercapnia
0.010 Biomarker disease BEFREE We believe that, if cardiac function has been preserved, VV ECMO should be considered a viable treatment strategy for CCB and ACE-I overdose resulting in refractory hypoxemic respiratory failure. 30175658 2019
CUI: C0458219
Disease: Complex Regional Pain Syndromes
Complex Regional Pain Syndromes
0.010 AlteredExpression disease BEFREE Epidemiologic data suggest that inactivation of the peptidase angiotensin-converting enzyme in patients treated for hypertension increases the odds to develop CRPS. 30694931 2019
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.010 GeneticVariation phenotype BEFREE In colorectal cancer (CRC), it was demonstrated that angiotensin I-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) may reduce the risk of CRC; however, their impact on tumor recurrence remains unknown. 31478086 2019
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.010 Biomarker disease BEFREE ACE2 was significantly increased in PTC in comparison to G, FA and UTC, and in FTC as compared to G. The ratio ACE/ACE2 decreased while ACE2/ACE increased with the differentiation grade of thyroid carcinoma. 31847529 2019
CUI: C0549622
Disease: Sexual Dysfunction
Sexual Dysfunction
0.010 Biomarker group BEFREE Treatment with alpha-/beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, and diuretics resulted in no statistical difference in sexual dysfunction in hypertensive women. 31113742 2019
CUI: C0702166
Disease: Acne
Acne
0.010 GeneticVariation disease BEFREE The aim of this work was to reveal the relation between the ACE gene I/D polymorphism and acne vulgaris development among a sample of patients. 31033180 2019
Mild non-proliferative diabetic retinopathy
0.010 Biomarker disease BEFREE In moderate NPDR, VD reduction extended to the inferior area in SCP and DCP compared with mild NPDR. 30810284 2019
CUI: C0848765
Disease: Hearing disability
Hearing disability
0.010 Biomarker disease BEFREE <b>Design:</b> The I-ACE was offered to adult clients seeking help for the first time and effects were measured for participants using self-report questionnaires: the Client Oriented Scale of Improvement (goal attainment), the Hearing Handicap Questionnaire (hearing disability), and the International Outcome Inventory - Alternative Interventions (outcomes) immediately after programme completion and 3 months later. 30929520 2019
CUI: C0854051
Disease: Allergy to sting
Allergy to sting
0.010 Biomarker disease BEFREE The European guidelines are limited to VIT and are based on a published systematic review; the US practice parameters cover all areas of the diagnosis and management of insect sting allergy and do not use the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach.There is general agreement that both children and adults with cutaneous systemic reactions do not require VIT, and that there is minimal risk associated with β-blockers and angiotensin-converting enzyme inhibitors during VIT. 31335358 2019
CUI: C1333324
Disease: Barretts esophagus with dysplasia
Barretts esophagus with dysplasia
0.010 Biomarker disease BEFREE Endoscopic biopsies are taken from 18 BE in patients with low-grade dysplasia before and after 3 weeks of treatment with either angiotensin-converting enzyme inhibitors (enalapril 5 mg; n = 6) or angiotensin II receptor type 1 blockers (candesartan 8 mg; n = 6), or no treatment (n = 6). 30666827 2019
CUI: C1536222
Disease: Non STEMI
Non STEMI
0.010 GeneticVariation disease BEFREE Women less frequently received 13 of the 16 quality indicators compared with men, including timely reperfusion therapy for STEMI (76.8% vs 78.9%; p<0.001), timely coronary angiography for non-STEMI (24.2% vs 36.7%; p<0.001), dual antiplatelet therapy (75.4% vs 78.7%) and secondary prevention therapies (87.2% vs 89.6% for statins, 82.5% vs 85.6% for ACE inhibitor/angiotensin receptor blockers and 62.6% vs 67.6% for beta-blockers; all p<0.001). 30470725 2019
CUI: C1761609
Disease: Aspiration pneumonitis
Aspiration pneumonitis
0.010 Biomarker disease BEFREE Association between Angiotensin-Converting Enzyme Inhibitors and Post-Stroke Aspiration Pneumonia. 31635965 2019
CUI: C2609266
Disease: Gastroesophageal varices
Gastroesophageal varices
0.010 GeneticVariation disease BEFREE The presence of the ACE I allele was associated with a higher HVPG value (18.7±6.4 vs 10.3±6.3mmHg; P<.001), higher frequency of large gastrooesophageal varices (59.3% vs 25.0%; P<.05), and higher frequency of variceal bleeding (63.0% vs 29.2%; P<.05). 30236768 2019
CUI: C2711248
Disease: Osteonecrosis of Jaw
Osteonecrosis of Jaw
0.010 GeneticVariation disease BEFREE The association of the high blood pressure D variant of the angiotensin-converting enzyme (ACE) gene with medication-related jaw osteonecrosis (MRONJ) is described in two Greek patients. 30804141 2019
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME
0.010 GeneticVariation group BEFREE Incorporating the revised International Prognostic Scoring System classification with the ACE-27 and TP53 mutation status improved outcome prediction in patients with MDS. 30861111 2019
CUI: C3494623
Disease: Mild dementia
Mild dementia
0.010 Biomarker disease BEFREE The optimal cutoff score of M-ACE to screen mild dementia (21/22) yielded satisfactory sensitivity (0.96) and specificity (0.87) with a comparable AUC to MMSE (0.96 vs 0.94). 30987514 2019
CUI: C3887709
Disease: Optic Neuropathy
Optic Neuropathy
0.010 AlteredExpression disease BEFREE Inclusion criteria were unilateral chronic optic neuropathy and a work-up including contrast-enhanced MRI brain and orbits, CBC, ESR, CRP, ANA, CMIA, and ACE. 30760894 2019
CUI: C4021107
Disease: Non-obstructive azoospermia
Non-obstructive azoospermia
0.010 GeneticVariation disease BEFREE The objective of this study was to explore the relationship between non-obstructive azoospermia (NOA) and single-nucleotide polymorphisms in the angiotensin-converting enzyme gene (ACE) using ligase detection reaction (LDR)-PCR. 31198195 2019
CUI: C4721414
Disease: Mantle cell lymphoma
Mantle cell lymphoma
0.010 Biomarker disease BEFREE Individual data from 124 patients treated with acalabrutinib in the Phase II ACE-LY-004 trial were adjusted to match average baseline characteristics of populations from studies using alternative targeted treatment regimens for relapsed/refractory MCL (for monotherapy: ibrutinib, bortezomib, lenalidomide, and temsirolimus; for combination therapies: ibrutinib + rituximab, bendamustine + rituximab, and lenalidomide + rituximab). 31699438 2019
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis
0.010 Biomarker disease BEFREE Our findings suggest that treating with the ACE inhibitors captopril has a significant benefit in overcoming pathological changes associated with MF. 29971909 2018
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder
0.010 Biomarker disease BEFREE 108 participants with comorbid AUD were compared to 302 participants without comorbid AUD concerning traumatic experiences during childhood and adolescence (Adverse Childhood Experiences Questionnaire; ACE), parental bonding (Parental Bonding Instrument; PBI), and personality (Temperament and Character Inventory; TCI). 29477673 2018