ACE, angiotensin I converting enzyme, 1636

N. diseases: 1082; N. variants: 82
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024440
Disease: Macular Edema, Cystoid
Macular Edema, Cystoid
0.010 Biomarker disease BEFREE Strong correlation was found between the vessel density in the perifoveal ICP and DCP and outer retinal thickness in RP patients with no history of cystoid macular edema. 30849344 2019
CUI: C0025290
Disease: Aseptic Meningitis
Aseptic Meningitis
0.010 AlteredExpression disease BEFREE Measurement of cerebrospinal fluid ACE level in aseptic meningitis: diagnostic? 31451467 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.010 GeneticVariation disease BEFREE This suggests possible association of <i>ACE</i> I/D gene polymorphism with MM. 30788288 2019
CUI: C0026848
Disease: Myopathy
Myopathy
0.010 Biomarker group BEFREE In the present study, we evaluated the potential of ACE-083 - a locally acting, follistatin-based fusion protein - as a novel therapeutic agent for focal or asymmetric myopathies. 31388039 2019
CUI: C0027543
Disease: Avascular necrosis of bone
Avascular necrosis of bone
0.010 Biomarker phenotype BEFREE For severe genotypes, angiotensin-converting enzyme-inhibitor/angiotensin receptor blocker use (OR, 6.10; 95% CI, 2.03-18.29; P=0.001) and avascular necrosis (OR, 0.40; 95% CI, 0.16-0.97; P=0.04) were associated with baseline CKD. 30797615 2019
CUI: C0029132
Disease: Disorder of the optic nerve
Disorder of the optic nerve
0.010 AlteredExpression group BEFREE Inclusion criteria were unilateral chronic optic neuropathy and a work-up including contrast-enhanced MRI brain and orbits, CBC, ESR, CRP, ANA, CMIA, and ACE. 30760894 2019
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.010 Biomarker disease BEFREE Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers induced pemphigus: A case series and literature review. 30238580 2019
CUI: C0032290
Disease: Aspiration Pneumonia
Aspiration Pneumonia
0.010 Biomarker disease BEFREE Association between Angiotensin-Converting Enzyme Inhibitors and Post-Stroke Aspiration Pneumonia. 31635965 2019
CUI: C0035334
Disease: Retinitis Pigmentosa
Retinitis Pigmentosa
0.010 Biomarker disease BEFREE PR-OCTA enables the detection of microvascular changes in the perifoveal regions of the ICP and DCP in RP, with relative sparing of the SVC. 30849344 2019
CUI: C0036416
Disease: Scleritis
Scleritis
0.010 Biomarker disease BEFREE Confirmatory studies of whether adjunctive ACE inhibitor or statin treatment truly can enhance scleritis remission (as suggested here) are needed. 30951689 2019
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders
0.010 Biomarker group BEFREE We searched for the terms "calcium-channel blockers" or "angiotensin-converting enzyme inhibitors" or "angiotensin II receptors blockers" or "diuretics" or "beta blockers" AND "dermatological effects" or "skin disease". 31195782 2019
CUI: C0039128
Disease: Syphilis
Syphilis
0.010 Biomarker disease BEFREE Routine screening blood work (ACE, ANA, CMIA) and MRI brain and orbits for chronic idiopathic unilateral optic neuropathy has low diagnostic yield, especially if clinical suspicion for syphilis, lupus, and sarcoidosis is low. 30760894 2019
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.010 Biomarker disease BEFREE We examined in this study the expression of ACE and ACE2 in thyroid tissues and their possible employment as biomarkers for thyroid cancer progression. 31847529 2019
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.010 GeneticVariation disease BEFREE About 40 (21.2%) pregnant women were identified by the T-ACE as at-risk for problem drinking during pregnancy. 31805891 2019
CUI: C0151857
Disease: Pleocytosis
Pleocytosis
0.010 AlteredExpression disease BEFREE CSF studies demonstrated lymphocyte predominant pleocytosis with an elevated ACE level. 31451467 2019
CUI: C0154933
Disease: Adhesions of iris
Adhesions of iris
0.010 Biomarker disease BEFREE An older age at diagnosis (p=0.004) and the presence of synechiae (p=0.02) were significantly related to an abnormal <sup>18</sup>F-FDG PET/CT, with a trend for an elevated ACE (p=0.0993). 30658987 2019
CUI: C0205647
Disease: Follicular adenoma
Follicular adenoma
0.010 Biomarker disease BEFREE Thyroid tissues including 14 goiters (G), 12 follicular adenomas (FA), 10 follicular thyroid carcinomas (FTC), 14 papillary thyroid carcinomas (PTC) and 11 undifferentiated thyroid carcinomas (UTC) were subjected to RT-PCR and protein analyses with primers or antibodies specific for ACE and ACE2, respectively. 31847529 2019
CUI: C0206682
Disease: Follicular thyroid carcinoma
Follicular thyroid carcinoma
0.010 AlteredExpression disease BEFREE ACE2 was significantly increased in PTC in comparison to G, FA and UTC, and in FTC as compared to G. The ratio ACE/ACE2 decreased while ACE2/ACE increased with the differentiation grade of thyroid carcinoma. 31847529 2019
CUI: C0236734
Disease: Caffeine related disorders
Caffeine related disorders
0.010 AlteredExpression group BEFREE Some common genes that are included in nutrition-based multigene test panels include CYP1A2 (rate of caffeine break down), MTHFR (folate usage), NOS3 (risk of elevated triglyceride levels related to omega-3 fat intake), and ACE (blood pressure response in related to sodium intake). 31254340 2019
CUI: C0238421
Disease: Selenium deficiency
Selenium deficiency
0.010 Biomarker disease BEFREE The use of the I-ACE software in a 6-month, 4-session dietician-delivered lifestyle counseling intervention improved the efficiency of lifestyle education, compared with SLA, among low-SES, ethnic minority patients with T2DM. 31621640 2019
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.010 AlteredExpression disease BEFREE ACE2 was significantly increased in PTC in comparison to G, FA and UTC, and in FTC as compared to G. The ratio ACE/ACE2 decreased while ACE2/ACE increased with the differentiation grade of thyroid carcinoma. 31847529 2019
CUI: C0240225
Disease: Liver mass
Liver mass
0.010 Biomarker phenotype BEFREE <b>Abbreviations</b>: Angiotensin-converting enzyme (ACE); Angiotensin converting enzyme inhibitors (ACEIs); Angiotensin II (ANG II); Analysis of variance (ANOVA); Angiotensin receptor blockers (ARBs); Blood Pressure (BP); Calcium Antagonists Calcium Channel Blockers (CCB); Chronic kidney diseases (CKD); Sodium carboxyl methyl cellulose (CMC-Na); Cardiac mass index (CMI); Cardiovascular diseases (CVD); Diastolic blood pressure (DBP); Enzyme-linked immunosorbent assay (ELISA); Hematoxylin-eosin (H&E); Kidney mass index (KMI); Liver mass index (LMI); Mean arterial blood pressure (MAP); Plasma renin concentration (PRC); Renin-angiotensin system (RAS); Rennin (REN); Systolic blood pressure (SBP); Student-Newman-Keuls q test (SNK-q test); Spontaneous hypertension rats (SHR); Valsartan asleep Administration (VSA); Valsartan awake Administration (VWA); Wistar-Kyoto (WKY); Mesor (M); Amplitude (A); Phase (φ). 31096810 2019
CUI: C0263478
Disease: Ophiasis
Ophiasis
0.010 AlteredExpression disease BEFREE Among cases, serum ACE activity was significantly higher in patients with more severe disease (P = 0.030), nonpatchy alopecia areata (alopecia universalis; ophiasis, patchy and ophiasis, diffuse) (P = 0.029), and with nail involvement (P = 0.027). 29582789 2019
CUI: C0263505
Disease: Alopecia universalis
Alopecia universalis
0.010 AlteredExpression disease BEFREE Among cases, serum ACE activity was significantly higher in patients with more severe disease (P = 0.030), nonpatchy alopecia areata (alopecia universalis; ophiasis, patchy and ophiasis, diffuse) (P = 0.029), and with nail involvement (P = 0.027). 29582789 2019
CUI: C0264722
Disease: Chronic congestive heart failure
Chronic congestive heart failure
0.010 GeneticVariation disease BEFREE The long-term benefits of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) on outcomes in patients with chronic congestive heart failure are well-known, making them one of the most widely prescribed medications. 31797310 2019