|
Liver diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This study was conducted to determine whether polymorphisms near or in interferon-lambda (IFN-λs) genes and their receptor genes such as interleukin 28 receptor, alpha (IL28RA) and interleukin 10 receptor, beta (IL10RB) as well as p21-activated kinases 4 (PAK4) and iron/zinc purple acid phosphatase-like protein (PAPL), which are locate upstream of IFN-λs, and lastly the DEPDC5 gene are associated with hepatitis B virus-related liver disease in Han Chinese.
|
25032264 |
2014 |
|
Lymphocytic Choriomeningitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In agreement with this observation, we showed that LCMV infection significantly reduces IFNLR1 mRNA expression in infected cells.
|
25830339 |
2015 |
|
Multiple Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis.
|
22386267 |
2012 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry revealed that both IL-29 and IL-28Ra were dramatically elevated in OA synovium compared to HC; synovial fibroblasts (FLS) and macrophages were the main IL-29-producing cells in OA synovium.
|
27433031 |
2016 |
|
Infection by Trichuris trichiura
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate that whilst IL-22Rα and IL-28Rα are dispensable in the host response to whipworms, IL-10 signalling through IL-10Rα and IL-10Rβ is essential to control caecal pathology, worm expulsion and survival during T. muris infections.
|
30640950 |
2019 |
|
Vitiligo
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated possible changes in the expression of interleukin (IL)-10 family cytokines (IL26, IL-28A, IL28B, IL29), their receptor subunits (IL20RB, IL22RA2, IL28RA), and genes potentially related to functioning of melanocytes (MDM1, IFNA1, IFNB1, IFNG, and ICAM1) in the case of vitiligo.
|
22333690 |
2012 |
|
Non-arthropod borne lymphocytic choriomeningitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In agreement with this observation, we showed that LCMV infection significantly reduces IFNLR1 mRNA expression in infected cells.
|
25830339 |
2015 |
|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This strategy of inhibiting IL28RA gene expression may reduce reperfusion injury in the treatment of patients with acute myocardial infarction.
|
28639948 |
2017 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IL28RA is lowly expressed in pancreatic cancer patients, and has certain diagnostic value for early pancreatic cancer.
|
31799654 |
2019 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found human IL28RA was expressed in lymphs, testes, lymphoma, teratocarcinoma, pediatric pre-B cell acute lymphoblastic leukemia, germinal center B cells, embryonic stem cells, fetal lung, and also expressed in bladder, blood and breast cancers, glioma, head and neck cancer and lung cancer tissues.
|
20372826 |
2010 |
|
Psoriasis vulgaris
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study provides evidence for the involvement of ERAP1, IL28RA, GJB2 and PTTG1 loci in PsA susceptibility and confirmed the previously reported association with PsA and PsV.
|
23252691 |
2013 |
|
Herpes encephalitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The first set represented eleven non-synonymous variants in six different genes involved in interferon (IFN) induction, present in a cohort of patients suffering from herpes simplex encephalitis (HSE) and the second set represented sixteen allelic variants of the IFNLR1 gene.
|
29217828 |
2019 |
|
Rhinovirus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity.
|
29549834 |
2018 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IL28RA is lowly expressed in pancreatic cancer patients, and has certain diagnostic value for early pancreatic cancer.
|
31799654 |
2019 |
|
Hepatitis C, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies.
|
24752298 |
2014 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found human IL28RA was expressed in lymphs, testes, lymphoma, teratocarcinoma, pediatric pre-B cell acute lymphoblastic leukemia, germinal center B cells, embryonic stem cells, fetal lung, and also expressed in bladder, blood and breast cancers, glioma, head and neck cancer and lung cancer tissues.
|
20372826 |
2010 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Meta-analysis of the prognostic value of IL28RA genes in various cancers found that the expression of IL28RA was indeed related to the cancer prognosis in certain cancers.
|
20372826 |
2010 |
|
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found human IL28RA was expressed in lymphs, testes, lymphoma, teratocarcinoma, pediatric pre-B cell acute lymphoblastic leukemia, germinal center B cells, embryonic stem cells, fetal lung, and also expressed in bladder, blood and breast cancers, glioma, head and neck cancer and lung cancer tissues.
|
20372826 |
2010 |
|
Eosinophilic disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
These results suggest that IFNLR1 are increased in HRV-infected infants with more severe bronchiolitis and blood eosinophilia and in those infected with the HRVC species.
|
29549834 |
2018 |
|
Sjogren's Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we sought to investigate the expression of type III IFNs and their common receptor IFN-λR1/IL-28Ra in Sjögren's syndrome (SS).
|
27613139 |
2016 |
|
Progressive sensorineural hearing impairment
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<b>Results</b> We identified a cosegregating heterozygous missense mutation, c.296G>A (p.Arg99His) in the gene encoding interferon lambda receptor 1 (<i>IFNLR1</i>) - a protein that functions in the Jak/ STAT pathway- are associated with <i>ADNSHL</i> Morpholino knockdown of ifnlr1 leads to a significant decrease in hair cells and non-inflation of the swim bladder in late-stage zebrafish, which can be reversed by injection with normal Zebrafish <i>ifnlr1</i> mRNA.
|
29453195 |
2018 |
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated possible changes in the expression of interleukin (IL)-10 family cytokines (IL26, IL-28A, IL28B, IL29), their receptor subunits (IL20RB, IL22RA2, IL28RA), and genes potentially related to functioning of melanocytes (MDM1, IFNA1, IFNB1, IFNG, and ICAM1) in the case of vitiligo.
|
22333690 |
2012 |
|
Pseudohyperkalemia Cardiff
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The analysis of liver biopsies of patients with CHC revealed a strong association of high IFN-λR1 expression with elevated ISG expression, with IFN-λ3 minor alleles, and with nonresponse to pegylated IFN-α and ribavirin.
|
24752298 |
2014 |
|
Allergic rhinitis (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that the g.32349 G>A polymorphism of IL-28RA might be associated with susceptibility to allergic rhinitis (P=0.032), but seems to have no relationship with serum total IgE levels.
|
16819289 |
2006 |
|
Psoriasis
|
0.330 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |