Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of DLX2 confers a poor prognosis in glioblastoma patients by inducing a proliferative phenotype.
|
23331016 |
2013 |
AL-RAQAD SYNDROME
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Altogether these data suggest a molecular mechanism for tooth development involving Dlx2 gene expression in ARS patients.
|
11929847 |
2002 |
AL-RAQAD SYNDROME
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Gene expression profiling of homozygous Pitx2 mutant mouse tissue reveals decreased Dlx2 expression as a potential molecular basis for developmental defects associated with ARS patients.
|
15751970 |
2005 |
Autism Spectrum Disorders
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The DLX1and DLX2 genes and susceptibility to autism spectrum disorders.
|
18728693 |
2009 |
Autistic Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The DLX1 and DLX2 genes lie head-to-head in 2q32, a region associated with autism susceptibility.
|
18728693 |
2009 |
Autistic Disorder
|
0.320 |
Biomarker
|
disease |
CTD_human |
The DLX1 and DLX2 genes lie head-to-head in 2q32, a region associated with autism susceptibility.
|
18728693 |
2009 |
Autistic Disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
Genetic studies have reported an association between autism and DLX2, HOXA1, EN2, ARX, and FOXP2 genes whereas only three studies of EN2, OTX2, and FOXP2 were performed on schizophrenia.
|
19018235 |
2008 |
Autistic Disorder
|
0.320 |
GeneticVariation
|
disease |
LHGDN |
The DLX1 and DLX2 genes lie head-to-head in 2q32, a region associated with autism susceptibility.
|
18728693 |
2009 |
Axenfeld-Rieger syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This mutation is associated with iris hypoplasia (IH); in contrast a Rieger syndrome mutation, PITX2 T68P, which presents clinically with the full spectrum of developmental anomalies (including tooth anomalies), is unable to transactivate the Dlx2 promoter.
|
11929847 |
2002 |
Brain Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
DLX1 and/or DLX2 activated the transcription of both <i>Gad</i> genes, and defects in <i>Dlx</i> function disrupted the differentiation of GABAergic interneurons with global reduction in GABA levels in the forebrains of the <i>Dlx1/Dlx2</i> double knock-out mouse <i>in vivo</i> Identification of <i>Gad</i> genes as direct <i>Dlx</i> transcriptional targets is significant; it extends our understanding of <i>Dlx</i> gene function in the developing forebrain beyond the regulation of tangential interneuron migration to the differentiation of GABAergic interneurons arising from the basal telencephalon, and may help to unravel the pathogenesis of several developmental brain disorders.<b>SIGNIFICANCE STATEMENT</b> GABA is the major inhibitory neurotransmitter in the brain.
|
28821666 |
2017 |
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our studies indicate that DLX genes are involved in human breast cancer progression, and that DLX2 and DLX5 genes might serve as prognostic markers.
|
21108812 |
2010 |
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of DLX2 confers a poor prognosis in glioblastoma patients by inducing a proliferative phenotype.
|
23331016 |
2013 |
Craniofacial Abnormalities
|
0.300 |
Biomarker
|
group |
CTD_human |
Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches.
|
9187081 |
1997 |
Deformity of limb
|
0.010 |
Biomarker
|
group |
BEFREE |
The 2q31.1 deletion resulted in the loss of one copy of several known disease genes, including GAD1, DCAF17, SLC25A12 and ITGA6 associated with mental retardation and facial abnormalities and DLX1/DLX2 partially associated with limb abnormalities.
|
24412318 |
2014 |
Dental fluorosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results provided evidence that polymorphisms in TIMP1, DLX1 and DLX2 genes may be associated with DF phenotypes.
|
28131910 |
2017 |
Dental Fluorosis, Acquired
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results provided evidence that polymorphisms in TIMP1, DLX1 and DLX2 genes may be associated with DF phenotypes.
|
28131910 |
2017 |
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
As a strategy to define the embryonic origin and neurochemical phenotype of cells in this disease, we probed specimens (n = 10) resected during epilepsy surgery with a panel of 13 antibodies recognizing proteins associated with (i) specific progenitor cell types including brain lipid binding protein (BLBP), collapsin response mediator protein 4 (CRMP4), Dlx1, Dlx2, GFAPdelta, MASH1, Otx1, Pax6, vimentin and phosphorylated vimentin and (ii) excitatory or inhibitory neurochemical phenotypes such as the vesicular glutamate transporters-1 and 2 (VGLUT-1, VGLUT-2), or the vesicular GABA transporter (VGAT).
|
17711980 |
2007 |
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of DLX2 confers a poor prognosis in glioblastoma patients by inducing a proliferative phenotype.
|
23331016 |
2013 |
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these data identified high expression of DLX2 as a poor prognostic marker to GBM patients.
|
23331016 |
2013 |
Hematologic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The distal-less homeobox2 (DLX2) gene encodes for a homeobox transcription factor involved in morphogenesis and its deregulation was found in human solid tumors and hematologic malignancies.
|
26799321 |
2016 |
Hypoplasia of iris
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Since Dlx2 expression is required for tooth and craniofacial development the lack of tooth anomalies in the patient with IH may be due to the residual activity of this mutant in activating the Dlx2 promoter.
|
11929847 |
2002 |
Intellectual Disability
|
0.010 |
Biomarker
|
group |
BEFREE |
The 2q31.1 deletion resulted in the loss of one copy of several known disease genes, including GAD1, DCAF17, SLC25A12 and ITGA6 associated with mental retardation and facial abnormalities and DLX1/DLX2 partially associated with limb abnormalities.
|
24412318 |
2014 |
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HCC cells with higher DLX2 expression were more sensitive to acRoots.
|
30415058 |
2019 |
Lymphoproliferative Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
TRAF1 is amongst the most highly TES1-induced target genes and is abundantly expressed in EBV-associated lymphoproliferative disorders.
|
25996949 |
2015 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our studies indicate that DLX genes are involved in human breast cancer progression, and that DLX2 and DLX5 genes might serve as prognostic markers.
|
21108812 |
2010 |