Autistic Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The DLX1 and DLX2 genes lie head-to-head in 2q32, a region associated with autism susceptibility.
|
18728693 |
2009 |
Autistic Disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
Genetic studies have reported an association between autism and DLX2, HOXA1, EN2, ARX, and FOXP2 genes whereas only three studies of EN2, OTX2, and FOXP2 were performed on schizophrenia.
|
19018235 |
2008 |
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Annotation of mRNA profiling data on GBM from The Cancer Genome Atlas and MD Anderson Cancer Center showed the proneural and neural subtypes highly correlated with low and high DLX2 expression, respectively.
|
23331016 |
2013 |
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Finally, Dlx2 expression supports experimental tumour growth and metastasis of B16 melanoma cells and correlates with tumour malignancy in a variety of human cancer types.
|
21897365 |
2011 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Here we investigated the role of DLX2 in association with radiation-induced epithelial to mesenchymal transition (EMT) and stem cell-like properties and its regulation by Smad2/3 signaling in irradiated A549 and MDA-MB-231 human cancer cell lines.
|
26799321 |
2016 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
In the present study, we show that Distal-less 2 (Dlx-2), a homeobox gene of the Dlx family that is involved in embryonic development, is induced in cancer cell lines dependently of reactive oxygen species (ROS) in response to glucose deprivation (GD), one of the metabolic stresses occurring in solid tumors.
|
21917150 |
2011 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Genes involved in brain development and neuronal differentiation, such as BMP4, POU4F3, GDNF, OTX2, NEFM, CNTN4, OTP, SIM1, FYN, EN1, CHAT, GSX2, NKX6-1, PAX6, RAX, and DLX2, were strongly enriched among genes frequently methylated in tumors.
|
20233874 |
2010 |
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
We previously showed that distal-less homeobox-2 (Dlx-2), a homeodomain transcription factor involved in embryonic and tumor development, induces glycolytic switch and epithelial-mesenchymal transition (EMT) by inducing Snail expression.
|
26771232 |
2016 |
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Increased Dlx-2 expression was also detected in the inner regions, which experience metabolic stress, of human tumors and of a multicellular tumor spheroid, an in vitro model of solid tumors.
|
21917150 |
2011 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
These results establish Dlx2 as one critical player in shifting TGFβ from its tumour suppressive to its tumour-promoting functions.
|
21897365 |
2011 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Here we investigated the role of DLX2 in association with radiation-induced epithelial to mesenchymal transition (EMT) and stem cell-like properties and its regulation by Smad2/3 signaling in irradiated A549 and MDA-MB-231 human cancer cell lines.
|
26799321 |
2016 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
In the present study, we show that Distal-less 2 (Dlx-2), a homeobox gene of the Dlx family that is involved in embryonic development, is induced in cancer cell lines dependently of reactive oxygen species (ROS) in response to glucose deprivation (GD), one of the metabolic stresses occurring in solid tumors.
|
21917150 |
2011 |
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Finally, Dlx2 expression supports experimental tumour growth and metastasis of B16 melanoma cells and correlates with tumour malignancy in a variety of human cancer types.
|
21897365 |
2011 |
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Annotation of mRNA profiling data on GBM from The Cancer Genome Atlas and MD Anderson Cancer Center showed the proneural and neural subtypes highly correlated with low and high DLX2 expression, respectively.
|
23331016 |
2013 |
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Instead, in bone and lung metastases resulting from intravenous injection we detected expression of DLX5/6 but not of DLX2, suggesting that DLX5/6 are activated during metastasis formation, and that their expression is alternative to that of DLX2.
|
21108812 |
2010 |
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, Dlx2 expression supports experimental tumour growth and metastasis of B16 melanoma cells and correlates with tumour malignancy in a variety of human cancer types.
|
21897365 |
2011 |
Neoplasm Metastasis
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
Together, these results reveal an important role for DLX2-NRP2 in p53-R273H-induced cell mobility and tumor metastasis.
|
28796261 |
2017 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that Dlx-2 may be involved in tumor progression via the regulation of metabolic stress-induced necrosis.
|
21917150 |
2011 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Additionally, Shad1 influences the expression of additional prognostic markers of cancer progression such as DLX2 and IGFBP2.
|
25904138 |
2015 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Snail and Dlx-2 contribute to tumor progression by promoting necrosis and inducing EMT and oncogenic metabolism.
|
29636841 |
2018 |
Solid Neoplasm
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
The distal-less homeobox2 (DLX2) gene encodes for a homeobox transcription factor involved in morphogenesis and its deregulation was found in human solid tumors and hematologic malignancies.
|
26799321 |
2016 |
Solid Neoplasm
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Increased Dlx-2 expression was also detected in the inner regions, which experience metabolic stress, of human tumors and of a multicellular tumor spheroid, an in vitro model of solid tumors.
|
21917150 |
2011 |
AL-RAQAD SYNDROME
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Altogether these data suggest a molecular mechanism for tooth development involving Dlx2 gene expression in ARS patients.
|
11929847 |
2002 |
AL-RAQAD SYNDROME
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Gene expression profiling of homozygous Pitx2 mutant mouse tissue reveals decreased Dlx2 expression as a potential molecular basis for developmental defects associated with ARS patients.
|
15751970 |
2005 |
Brain Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
DLX1 and/or DLX2 activated the transcription of both <i>Gad</i> genes, and defects in <i>Dlx</i> function disrupted the differentiation of GABAergic interneurons with global reduction in GABA levels in the forebrains of the <i>Dlx1/Dlx2</i> double knock-out mouse <i>in vivo</i> Identification of <i>Gad</i> genes as direct <i>Dlx</i> transcriptional targets is significant; it extends our understanding of <i>Dlx</i> gene function in the developing forebrain beyond the regulation of tangential interneuron migration to the differentiation of GABAergic interneurons arising from the basal telencephalon, and may help to unravel the pathogenesis of several developmental brain disorders.<b>SIGNIFICANCE STATEMENT</b> GABA is the major inhibitory neurotransmitter in the brain.
|
28821666 |
2017 |