|
Autoimmune Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
To continue our previous investigations, we have extensively investigated the function of the 61, 41, and 35 non-synonymous single nucleotide polymorphisms (SNPs) in the human genes encoding DNASE1, DNASE1L3, and DNASE2, respectively, potentially relevant to autoimmune diseases.
|
27116004 |
2016 |
|
Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
DNase II(-/-) embryos suffer from lethal anemia due to IFN-beta produced in the macrophages carrying undigested DNA.
|
20706988 |
2010 |
|
Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Most Dnase1 and Dnase2 family members are poorly characterized, yet their elimination can lead to a wide range of diseases, including lethal anemia, parakeratosis, cataracts and systemic lupus erythematosus.
|
28666955 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The inhibitory action on DNL exerted by T2 makes this compound a potential and attractive drug for the treatment of some metabolic diseases and cancer.
|
28362337 |
2017 |
|
Fatty Liver
|
0.020 |
Biomarker
|
disease |
BEFREE |
Inhibition of DNL is a successful approach to reverse hepatic steatosis, as shown by different studies in mice and humans.
|
30630736 |
2019 |
|
Fatty Liver
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we give an overview of the mechanisms of THs action on liver fatty acid metabolism, focusing on the different effects exerted by T2 and T3 on the regulation of the DNL.
|
28362337 |
2017 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
SNPs in DNL genes may serve as independent prognostic markers for HCC patients after surgery.
|
25826294 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the SNPs in DNL genes may serve as independent prognostic markers for NSCLC patients after surgery.
|
25227797 |
2014 |
|
Parakeratosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results of this study suggest that cornification of epidermal keratinocytes depends on the cooperation of DNase1L2 and DNase2 and indicate that parakeratosis per se does not suffice to cause skin pathologies.
|
28743926 |
2017 |
|
Trichinellosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Several enzymes (e.g., adult-specific DNase II, serine protease and serine protease inhibitor) could be the invasion-related proteins and early diagnostic markers for trichinellosis.Moreover, recombinant <i>T. spiralis</i> serine protease (rTsSP-ZH68) was expressed in <i>E. coli</i> and its antigenicity was analyzed by Western blot with the early infection sera.
|
28620363 |
2017 |
|
Polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inefficient and abnormal clearance of apoptotic cells (efferocytosis) contributes to systemic autoimmune disease in humans and mice, and inefficient chromosomal DNA degradation by DNAse II leads to systemic polyarthritis and a cytokine storm.
|
29118755 |
2017 |
|
Cytokine storm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inefficient and abnormal clearance of apoptotic cells (efferocytosis) contributes to systemic autoimmune disease in humans and mice, and inefficient chromosomal DNA degradation by DNAse II leads to systemic polyarthritis and a cytokine storm.
|
29118755 |
2017 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
The inhibitory action on DNL exerted by T2 makes this compound a potential and attractive drug for the treatment of some metabolic diseases and cancer.
|
28362337 |
2017 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of DNL is a successful approach to reverse hepatic steatosis, as shown by different studies in mice and humans.
|
30630736 |
2019 |
|
Autoimmune disease (systemic) NOS
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inefficient and abnormal clearance of apoptotic cells (efferocytosis) contributes to systemic autoimmune disease in humans and mice, and inefficient chromosomal DNA degradation by DNAse II leads to systemic polyarthritis and a cytokine storm.
|
29118755 |
2017 |
|
Fibrosis, Liver
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
In fatty livers, DNase II activity is suppressed in contrast to simple inactivation of Bcl-xL or Mcl-1, and both apoptotic and non-apoptotic hepatocyte death can develop, leading to the progression of liver fibrosis.
|
29855540 |
2019 |
|
Rheumatoid Arthritis
|
0.230 |
AlteredExpression
|
disease |
BEFREE |
Since the three SNPs in the promoter region of the DNase II gene could affect in vivo DNase II activity through reduction of the promoter activity, it is feasible to identify these SNPs susceptible to RA.
|
23019102 |
2012 |
|
Hypothyroidism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Based on these results, we can conclude that in the liver of hypothyroid rats the transcriptional activation by T2 of DNL genes could depend, at least in part, on SREBP-1- and ChREBP-dependent mechanisms.© 2019 IUBMB Life, 2019.
|
30707786 |
2019 |