|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Malignant neoplasm of prostate
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
There are two transcriptional variants of DPYSL3 gene in human genome, of which the variant 2 is the dominant transcript (DPYSL3v2, CRMP4a) but is also significantly down-regulated in primary prostate cancers.
|
27014974 |
2016 |
|
Malignant neoplasm of prostate
|
0.080 |
Biomarker
|
disease |
BEFREE |
This proof-of-concept study with dTALEs for locus-specific epigenomic manipulation validates the selected CpG methylation of CRMP4 gene as an independent biomarker for diagnosis and prognosis of prostate cancer metastasis and opens up a novel avenue for mechanistic research on cancer biology.
|
25888628 |
2015 |
|
Malignant neoplasm of prostate
|
0.080 |
Biomarker
|
disease |
BEFREE |
Taken together, our research indicated CRMP4 inhibits prostate cancer cells growth in the nude mouse bone microenvironment and this effect may relate with regulation of NRP1 and Noggin expression.
|
25338524 |
2015 |
|
Malignant neoplasm of prostate
|
0.080 |
PosttranslationalModification
|
disease |
BEFREE |
We then focused on the cooperative crosstalk of calpain-2 and NF-κB RelA/p65 in CRMP4 promoter methylation for the initiation of PCa metastasis.
|
29601651 |
2018 |
|
Malignant neoplasm of prostate
|
0.080 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data demonstrated that saRNA-based DPYSL3 gene enhancement is capable of suppressing tumor metastasis in prostate cancer, which provides a potential therapeutic approach for cancer management.
|
28639202 |
2019 |
|
Malignant neoplasm of prostate
|
0.080 |
Biomarker
|
disease |
BEFREE |
CRMP4 promoter methylation in diagnostic biopsies could be a robust biomarker for LNM in PCa.
|
28122909 |
2017 |
|
Malignant neoplasm of prostate
|
0.080 |
PosttranslationalModification
|
disease |
BEFREE |
Combined analysis of CRMP4 methylation levels and CAPRA-S score predicts metastasis and outcomes in prostate cancer patients.
|
28382925 |
2019 |
|
Malignant neoplasm of prostate
|
0.080 |
Biomarker
|
disease |
BEFREE |
Thus, in this study, we show new function of CRMP4 as a metastasis-suppressor in PCa.
|
20543870 |
2010 |
|
Prostate carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Taken together, our research indicated CRMP4 inhibits prostate cancer cells growth in the nude mouse bone microenvironment and this effect may relate with regulation of NRP1 and Noggin expression.
|
25338524 |
2015 |
|
Prostate carcinoma
|
0.070 |
PosttranslationalModification
|
disease |
BEFREE |
Combined analysis of CRMP4 methylation levels and CAPRA-S score predicts metastasis and outcomes in prostate cancer patients.
|
28382925 |
2019 |
|
Prostate carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
CRMP4 promoter methylation in diagnostic biopsies could be a robust biomarker for LNM in PCa.
|
28122909 |
2017 |
|
Prostate carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Thus, in this study, we show new function of CRMP4 as a metastasis-suppressor in PCa.
|
20543870 |
2010 |
|
Prostate carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data demonstrated that saRNA-based DPYSL3 gene enhancement is capable of suppressing tumor metastasis in prostate cancer, which provides a potential therapeutic approach for cancer management.
|
28639202 |
2019 |
|
Prostate carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
This proof-of-concept study with dTALEs for locus-specific epigenomic manipulation validates the selected CpG methylation of CRMP4 gene as an independent biomarker for diagnosis and prognosis of prostate cancer metastasis and opens up a novel avenue for mechanistic research on cancer biology.
|
25888628 |
2015 |
|
Prostate carcinoma
|
0.070 |
PosttranslationalModification
|
disease |
BEFREE |
We then focused on the cooperative crosstalk of calpain-2 and NF-κB RelA/p65 in CRMP4 promoter methylation for the initiation of PCa metastasis.
|
29601651 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.030 |
Biomarker
|
disease |
BEFREE |
A previous result showed that collapsin response mediator protein 4 (CRMP4) promotor methylation can be used as a predictor for lymph node metastases in prostate biopsies.
|
29308052 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
In the training set, CRMP4 promoter methylation (≥15.0% methylated) was statistically significantly associated with LNM (P < 001).
|
28122909 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We used a proteomics approach to screen for metastasis-associated proteins and found that collapsin response mediator protein-4 (CRMP4) expression was inversely associated with the lymph node metastasis of prostate cancer (PCa).
|
20543870 |
2010 |
|
Malignant neoplasm of stomach
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
High DPYSL3 mRNA expression in GCs was significantly associated with more malignant phenotypes and was an independent prognostic factor.
|
25096402 |
2014 |
|
Malignant neoplasm of stomach
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The combination of serum ANOS1 and DPYSL3 levels increased the AUC value that discriminated patients with GC from healthy controls.
|
31377880 |
2020 |
|
Pancreatic carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, CRMP4 protein levels in primary tumors of pancreatic cancer (n = 53) were examined by immunohistochemistry and compared with the clinicopathological features of the tumors.
|
22805864 |
2013 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Understanding the mechanisms of CRMP4 would help us to develop novel therapeutic strategies against acute or chronic pancreatitis, and pancreatic cancer.
|
27207309 |
2016 |
|
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The correlation between DPYSL3 expression and the survival time of lung cancer patients were analyzed in KMPLOT database.
|
29514686 |
2018 |