|
Acute on chronic pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elevated CRMP4 levels were observed in the infiltrated lymphocytes as well as in the pancreas parenchyma of both acute and chronic pancreatitis.
|
27207309 |
2016 |
|
Adenocarcinoma of the prostate metastatic
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The CRMP4 promotor methylation level in paraffin-embedded tissues of the 10 patients with PMLP were determined and then compared to limited prostate cancer (LPCa) and its negative lymph node tissue [LPCa-LN (-) (10 cases)] and also to metastatic prostate adenocarcinoma (mPCa) and its positive lymph node tissue [mPCa-LN (+) (10 cases)].
|
29308052 |
2018 |
|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Adult Subependymal Giant Cell Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
p34cdc2, collapsin response mediator protein 4 (CRMP4), doublecortin (DCX), HuD, and NeuN expression was assessed in tuber (n = 16) and subependymal giant cell astrocytoma (SEGA; n = 6) specimens in tuberous sclerosis complex to define the developmental phenotype and lineage of giant cells (CGs) in these lesions.
|
12731003 |
2003 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, using novel phosphospecific antibodies, we demonstrate that phosphorylation of CRMP2 at Ser522 (Cdk5-mediated) is increased in Alzheimer's disease (AD) brain, while CRMP2 expression and phosphorylation of the closely related isoform CRMP4 are not altered.
|
17683481 |
2007 |
|
ATRIAL SEPTAL DEFECT 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
|
29196732 |
2017 |
|
Atrial Septal Defects
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
|
29196732 |
2017 |
|
Autism Spectrum Disorders
|
0.020 |
Biomarker
|
disease |
BEFREE |
This review summarizes current knowledge regarding the role of CRMP4 during brain development and discusses the possible contribution of CRMP4 deficiencies or abnormalities to the pathogenesis of ASD.
|
31137494 |
2019 |
|
Autism Spectrum Disorders
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Whole-exome sequencing detected a de novo variant (S541Y) of CRMP4 in a male ASD patient.
|
29196732 |
2017 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer.
|
30498031 |
2018 |
|
Carcinoma of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We found genome-wide significant (P < 5.0 × 10(-8)) evidence for three additional lung cancer susceptibility loci at 10p14 (rs1663689, close to GATA3, P = 2.84 × 10(-10)), 5q32 (rs2895680 in PPP2R2B-STK32A-DPYSL3, P = 6.60 × 10(-9)) and 20q13.2 (rs4809957 in CYP24A1, P = 1.20 × 10(-8)).
|
22797725 |
2012 |
|
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The correlation between DPYSL3 expression and the survival time of lung cancer patients were analyzed in KMPLOT database.
|
29514686 |
2018 |
|
Carcinoma, Lewis Lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Stable DPYSL3 knockdown Lewis lung carcinoma (LLC) cells were constructed with a retroviral system.
|
29514686 |
2018 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data indicated that DPYSL3, not DPYSL1 or DPYSL2, is negatively regulated by MYCN and may be used as a potential biomarker for NB.
|
24011394 |
2013 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data indicated that DPYSL3, not DPYSL1 or DPYSL2, is negatively regulated by MYCN and may be used as a potential biomarker for NB.
|
24011394 |
2013 |
|
Childhood Subependymal Giant Cell Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
p34cdc2, collapsin response mediator protein 4 (CRMP4), doublecortin (DCX), HuD, and NeuN expression was assessed in tuber (n = 16) and subependymal giant cell astrocytoma (SEGA; n = 6) specimens in tuberous sclerosis complex to define the developmental phenotype and lineage of giant cells (CGs) in these lesions.
|
12731003 |
2003 |
|
Down Syndrome
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Evaluation of DRP-2, DRP-3 and DRP-4 revealed significantly decreased levels of 2 of the 15 spots assigned to DRP-2 and increased levels of one spot assigned to DRP-3 and increased DRP-4 in DS brain.
|
11771764 |
2001 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
As a strategy to define the embryonic origin and neurochemical phenotype of cells in this disease, we probed specimens (n = 10) resected during epilepsy surgery with a panel of 13 antibodies recognizing proteins associated with (i) specific progenitor cell types including brain lipid binding protein (BLBP), collapsin response mediator protein 4 (CRMP4), Dlx1, Dlx2, GFAPdelta, MASH1, Otx1, Pax6, vimentin and phosphorylated vimentin and (ii) excitatory or inhibitory neurochemical phenotypes such as the vesicular glutamate transporters-1 and 2 (VGLUT-1, VGLUT-2), or the vesicular GABA transporter (VGAT).
|
17711980 |
2007 |
|
Lentivirus Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The stable prostate cancer cells overexpressing the CRMP4 gene were constructed using lentivirus infection.
|
25338524 |
2015 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DPYSL3 mRNA levels were down-regulated in most HCC cell lines with DPYSL3 promoter hypermethylation, and expression was restored after demethylation.
|
25173447 |
2015 |
|
Lung Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
A metastatic lung tumor model in which the stable DPYSL3 knockdown LLC cells were injected through tail vein was used to analyze the role of DPYSL3 in tumor metastasis in vivo.
|
29514686 |
2018 |
|
Lymphoma
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
Collapsin response mediator protein 4 promotor methylation level as a potential predictor for diagnosing primary malignant lymphoma of the prostate.
|
29308052 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer.
|
30498031 |
2018 |
|
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The correlation between DPYSL3 expression and the survival time of lung cancer patients were analyzed in KMPLOT database.
|
29514686 |
2018 |
|
Malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We found genome-wide significant (P < 5.0 × 10(-8)) evidence for three additional lung cancer susceptibility loci at 10p14 (rs1663689, close to GATA3, P = 2.84 × 10(-10)), 5q32 (rs2895680 in PPP2R2B-STK32A-DPYSL3, P = 6.60 × 10(-9)) and 20q13.2 (rs4809957 in CYP24A1, P = 1.20 × 10(-8)).
|
22797725 |
2012 |