|
Tumor Progression
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
Receiver-operating characteristic curve analysis indicated that CRMP4 methylation levels ≥15% served as a significant prognostic marker of tumor progression and CSM.
|
28382925 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer.
|
30498031 |
2018 |
|
Lung Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
A metastatic lung tumor model in which the stable DPYSL3 knockdown LLC cells were injected through tail vein was used to analyze the role of DPYSL3 in tumor metastasis in vivo.
|
29514686 |
2018 |
|
Lymphoma
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
Collapsin response mediator protein 4 promotor methylation level as a potential predictor for diagnosing primary malignant lymphoma of the prostate.
|
29308052 |
2018 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to analyze the correlation between DPYSL3 and metastatic lung cancer.
|
29514686 |
2018 |
|
Carcinoma, Lewis Lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Stable DPYSL3 knockdown Lewis lung carcinoma (LLC) cells were constructed with a retroviral system.
|
29514686 |
2018 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer.
|
30498031 |
2018 |
|
Adenocarcinoma of the prostate metastatic
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The CRMP4 promotor methylation level in paraffin-embedded tissues of the 10 patients with PMLP were determined and then compared to limited prostate cancer (LPCa) and its negative lymph node tissue [LPCa-LN (-) (10 cases)] and also to metastatic prostate adenocarcinoma (mPCa) and its positive lymph node tissue [mPCa-LN (+) (10 cases)].
|
29308052 |
2018 |
|
Prostate Lymphoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Collapsin response mediator protein 4 promotor methylation level as a potential predictor for diagnosing primary malignant lymphoma of the prostate.
|
29308052 |
2018 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A Clinical Proteomic Tumor Analysis Consortium (CPTAC) proteogenomic analysis prioritized dihydropyrimidinase-like-3 (DPYSL3) as a multilevel (RNA/protein/phosphoprotein) expression outlier specific to the claudin-low (CLOW) subset of triple-negative breast cancers.
|
30498031 |
2018 |
|
Atrial Septal Defects
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
|
29196732 |
2017 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This module formed a scale-free network containing four hub genes (PAPLN, LBH, DPYSL3, and JAG1) overexpressed in advanced NAFLD.
|
28219123 |
2017 |
|
ATRIAL SEPTAL DEFECT 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
|
29196732 |
2017 |
|
Pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Pancreatitis induces CRMP4 expression in the pancreas parenchyma and in the infiltrated lymphocytes.
|
27207309 |
2016 |
|
Pancreatitis, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Understanding the mechanisms of CRMP4 would help us to develop novel therapeutic strategies against acute or chronic pancreatitis, and pancreatic cancer.
|
27207309 |
2016 |
|
Acute on chronic pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elevated CRMP4 levels were observed in the infiltrated lymphocytes as well as in the pancreas parenchyma of both acute and chronic pancreatitis.
|
27207309 |
2016 |
|
Lentivirus Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The stable prostate cancer cells overexpressing the CRMP4 gene were constructed using lentivirus infection.
|
25338524 |
2015 |
|
Secondary malignant neoplasm of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated whether overexpression of CRMP4 gene in prostate cancer cells inhibit tumor bone metastasis.
|
25338524 |
2015 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DPYSL3 mRNA levels were down-regulated in most HCC cell lines with DPYSL3 promoter hypermethylation, and expression was restored after demethylation.
|
25173447 |
2015 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data indicated that DPYSL3, not DPYSL1 or DPYSL2, is negatively regulated by MYCN and may be used as a potential biomarker for NB.
|
24011394 |
2013 |
|
Secondary malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggested that CRMP4 is significantly associated with poor prognosis by promoting liver metastasis and can serve as a novel therapeutic target for pancreatic cancer.
|
22805864 |
2013 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data indicated that DPYSL3, not DPYSL1 or DPYSL2, is negatively regulated by MYCN and may be used as a potential biomarker for NB.
|
24011394 |
2013 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Quantitative proteomic profiling identifies DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex.
|
24339867 |
2013 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data indicated that DPYSL3, not DPYSL1 or DPYSL2, is negatively regulated by MYCN and may be used as a potential biomarker for NB.
|
24011394 |
2013 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, using novel phosphospecific antibodies, we demonstrate that phosphorylation of CRMP2 at Ser522 (Cdk5-mediated) is increased in Alzheimer's disease (AD) brain, while CRMP2 expression and phosphorylation of the closely related isoform CRMP4 are not altered.
|
17683481 |
2007 |