Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that this baculovirus product has the proper conformation of the authentic PVA and that its conformation is important in pathogenicity of pemphigus.
|
8040292 |
1994 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alternatively, immunization with a combination of dsg3 protein along with other proteins might be necessary to induce pemphigus disease in adult mice.
|
12653831 |
2003 |
Pemphigus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also showed that the profile of anti-Dsg 1 and/or anti-Dsg 3 autoantibodies is associated with the clinical variant of pemphigus.
|
14646976 |
2003 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris is a rare chronic blistering skin disease resulting from IgG autoantibodies directed against transmembrane desmosomal glycoprotein desmoglein 3 and is the most common form of pemphigus.
|
31077459 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
TP did not directly block binding of pemphigus IgG to their target Dsg antigens but prevented PV-IgG-induced inhibition of Dsg3 transinteraction in cell-free (atomic force microscopy) and cell-based (laser tweezer) experiments, indicating stabilization of Dsg3 bonds.
|
19164289 |
2009 |
Pemphigus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ethnic group, age at presentation, initial intercellular antibody titre and initial Dsg 3 antibody levels all had a significant impact on prognosis of pemphigus.
|
24102444 |
2014 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, it was surprising that mice without desmoglein 3 (the autoantigen in pemphigus vulgaris) not only developed mucous membrane and skin lesions like pemphigus patients, but also developed hair loss.
|
9701552 |
1998 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dsg3 was the commonest positive substrate in pemphigus group (86%) with 100% sensitivity.
|
31211701 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives.
|
10951142 |
2000 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we examined the reactivity of the sera from various types of pemphigus with recombinant proteins of extracellular and intracellular domains of human Dsg1 and Dsg3 by immunoblot analysis.
|
11154866 |
2001 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations allow us to propose a concept for pemphigus blistering disorders as a "desmosome-remodeling impairment disease" involving a mechanism of Dsg3 nonassembly and depletion from desmosomes through PV immunoglobulin G-activated intracellular signaling events.
|
23257250 |
2013 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
BAIDs können in zwei Gruppen eingeteilt werden: Pemphigus-Erkrankungen, die durch intraepidermale Blasenbildung und Autoantikörper gegen desmosomale Proteine wie Desmoglein (Dsg) 1, Dsg3 und Mitglieder der Plakin-Familie charakterisiert sind, sowie subepidermale BAIDs, die Pemphigoid-Erkrankungen und die Dermatitis herpetiformis umfassen.
|
30179341 |
2018 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus is an autoimmune blistering disease targeting the desmosomal proteins desmoglein (Dsg) 1 and Dsg3.
|
31057535 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
To clone and express EC1-2 and EC3-4 epitopes of PVA (pemphigus vulgaris antigen, desmoglein-3) in order to diagnose pemphigus and study the relationship between epitopes of PVA and anti-PVA antibody.
|
11776114 |
2000 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion.
|
31178865 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment with Pemphigus auto-antibodies results in loss of monolayer integrity and altered localization of desmoglein-3, as well as loss of colocalization with flotillin-2.
|
31247885 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus is a life-threatening blistering disorder of the skin and mucous membranes caused by pathogenic autoantibodies to desmosomal adhesion proteins desmoglein 3 (Dsg3) and Dsg1.
|
15841178 |
2005 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, fundamental doubt has been raised towards this monopathogenic view by several independent factors: (1) pemphigus lesions can be induced in Dsg3-knockout (KO) mice; (2) pemphigus sera contain multiple autoantibodies against different adhesion molecules and also cholinergic receptors; (3) experimental inhibition of PV IgG induced acantholysis can be obtained by interference with different signaling cascades regulating both calcium homeostasis and apoptosis; and (4) cholinergic agonists exhibit anti-acantholytic activity both in vitro and in vivo.
|
17101498 |
2006 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data indicate that DP phosphorylation at S2849 represents an important mechanism in pemphigus pathogenesis, which, by reversing Ca(2+) insensitivity, promotes Dsg3 depletion.
|
25010392 |
2014 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to verify the pathogenic activity of anti-Desmocollin 3 (DSC3) antibodies, we developed an active disease model of pemphigus expressing anti-DSC3 autoantibodies or anti-DSC3 and anti-DSG3 antibodies.
|
31275323 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among these, two pathogenic T cell clones induced anti-Dsg3 IgG production and the development of a pemphigus phenotype when adoptively transferred with unprimed B cells from Dsg3(-/-) mice.
|
19155523 |
2009 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The serological diagnosis of pemphigus relies on the detection of IgG autoantibodies directed against the epithelial cell surface by indirect immunofluorescence (IIF) on monkey esophagus and against desmoglein 1 (Dsg1) and Dsg3 by ELISA.
|
29740444 |
2018 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evaluation of anti-desmoglein-1 and anti-desmoglein-3 autoantibody titers in pemphigus patients at the time of the initial diagnosis and after clinical remission.
|
29145342 |
2017 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris.
|
31774569 |
2020 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In all patients, the mean of pemphigus disease area index (PDAI) decreased from 20.3 ± 14.1 to 0.4 ± 0.0, whereas the mean Dsg3 value dropped from 157.1 ± 40.6 to 67.0 ± 26.6 after therapy with RTX.
|
31420993 |
2020 |