Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus is a life-threatening blistering disorder of the skin and mucous membranes caused by pathogenic autoantibodies to desmosomal adhesion proteins desmoglein 3 (Dsg3) and Dsg1.
|
15841178 |
2005 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus is an autoimmune blistering disease targeting the desmosomal proteins desmoglein (Dsg) 1 and Dsg3.
|
31057535 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dsg3 was the commonest positive substrate in pemphigus group (86%) with 100% sensitivity.
|
31211701 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alternatively, immunization with a combination of dsg3 protein along with other proteins might be necessary to induce pemphigus disease in adult mice.
|
12653831 |
2003 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among these, two pathogenic T cell clones induced anti-Dsg3 IgG production and the development of a pemphigus phenotype when adoptively transferred with unprimed B cells from Dsg3(-/-) mice.
|
19155523 |
2009 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity.
|
17428808 |
2007 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
BAIDs können in zwei Gruppen eingeteilt werden: Pemphigus-Erkrankungen, die durch intraepidermale Blasenbildung und Autoantikörper gegen desmosomale Proteine wie Desmoglein (Dsg) 1, Dsg3 und Mitglieder der Plakin-Familie charakterisiert sind, sowie subepidermale BAIDs, die Pemphigoid-Erkrankungen und die Dermatitis herpetiformis umfassen.
|
30179341 |
2018 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles.
|
12496453 |
2003 |
Pemphigus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ethnic group, age at presentation, initial intercellular antibody titre and initial Dsg 3 antibody levels all had a significant impact on prognosis of pemphigus.
|
24102444 |
2014 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evaluation of anti-desmoglein-1 and anti-desmoglein-3 autoantibody titers in pemphigus patients at the time of the initial diagnosis and after clinical remission.
|
29145342 |
2017 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Genetic characterization of human Dsg3-specific B cells isolated by flow cytometry from the peripheral blood of patients with pemphigus vulgaris.
|
18586466 |
2008 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In all patients, the mean of pemphigus disease area index (PDAI) decreased from 20.3 ± 14.1 to 0.4 ± 0.0, whereas the mean Dsg3 value dropped from 157.1 ± 40.6 to 67.0 ± 26.6 after therapy with RTX.
|
31420993 |
2020 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to verify the pathogenic activity of anti-Desmocollin 3 (DSC3) antibodies, we developed an active disease model of pemphigus expressing anti-DSC3 autoantibodies or anti-DSC3 and anti-DSG3 antibodies.
|
31275323 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we examined the reactivity of the sera from various types of pemphigus with recombinant proteins of extracellular and intracellular domains of human Dsg1 and Dsg3 by immunoblot analysis.
|
11154866 |
2001 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Intraperitoneal injection of pemphigus vulgaris-IgG into mouse depletes epidermal keratinocytes of desmoglein 3 associated with generation of acantholysis.
|
17431647 |
2007 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, fundamental doubt has been raised towards this monopathogenic view by several independent factors: (1) pemphigus lesions can be induced in Dsg3-knockout (KO) mice; (2) pemphigus sera contain multiple autoantibodies against different adhesion molecules and also cholinergic receptors; (3) experimental inhibition of PV IgG induced acantholysis can be obtained by interference with different signaling cascades regulating both calcium homeostasis and apoptosis; and (4) cholinergic agonists exhibit anti-acantholytic activity both in vitro and in vivo.
|
17101498 |
2006 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction.
|
18641320 |
2008 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris is a rare chronic blistering skin disease resulting from IgG autoantibodies directed against transmembrane desmosomal glycoprotein desmoglein 3 and is the most common form of pemphigus.
|
31077459 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion.
|
31178865 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data indicate that DP phosphorylation at S2849 represents an important mechanism in pemphigus pathogenesis, which, by reversing Ca(2+) insensitivity, promotes Dsg3 depletion.
|
25010392 |
2014 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris.
|
31774569 |
2020 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives.
|
10951142 |
2000 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The serological diagnosis of pemphigus relies on the detection of IgG autoantibodies directed against the epithelial cell surface by indirect immunofluorescence (IIF) on monkey esophagus and against desmoglein 1 (Dsg1) and Dsg3 by ELISA.
|
29740444 |
2018 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, it was surprising that mice without desmoglein 3 (the autoantigen in pemphigus vulgaris) not only developed mucous membrane and skin lesions like pemphigus patients, but also developed hair loss.
|
9701552 |
1998 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations allow us to propose a concept for pemphigus blistering disorders as a "desmosome-remodeling impairment disease" involving a mechanism of Dsg3 nonassembly and depletion from desmosomes through PV immunoglobulin G-activated intracellular signaling events.
|
23257250 |
2013 |