EGF, epidermal growth factor, 1950

N. diseases: 774; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2673648
Disease: Hypomagnesemia 4, Renal
Hypomagnesemia 4, Renal 		0.600 Biomarker disease CTD_human
CUI: C0028754
Disease: Obesity
Obesity 		0.150 Biomarker disease HPO
CUI: C0151723
Disease: Hypomagnesemia
Hypomagnesemia 		0.140 Biomarker phenotype HPO
CUI: C0018681
Disease: Headache
Headache 		0.100 Biomarker phenotype HPO
CUI: C0025958
Disease: Microcephaly
Microcephaly 		0.100 Biomarker disease HPO
CUI: C0026351
Disease: Moderate intellectual disability
Moderate intellectual disability 		0.100 Biomarker disease HPO
CUI: C0036572
Disease: Seizures
Seizures 		0.100 Biomarker phenotype HPO
CUI: C0042571
Disease: Vertigo
Vertigo 		0.100 Biomarker phenotype HPO
CUI: C0557874
Disease: Global developmental delay
Global developmental delay 		0.100 Biomarker disease HPO
CUI: C0746674
Disease: Generalized muscle weakness
Generalized muscle weakness 		0.100 Biomarker phenotype HPO
CUI: C0856975
Disease: Autistic behavior
Autistic behavior 		0.100 Biomarker disease HPO
CUI: C1531647
Disease: Cerebral ventriculomegaly
Cerebral ventriculomegaly 		0.100 Biomarker phenotype HPO
CUI: C1846176
Disease: Hyperactive deep tendon reflexes
Hyperactive deep tendon reflexes 		0.100 Biomarker phenotype HPO
CUI: C1848207
Disease: Poor speech
Poor speech 		0.100 Biomarker phenotype HPO
CUI: C1857704
Disease: Abnormal myelination
Abnormal myelination 		0.100 Biomarker phenotype HPO
CUI: C2237142
Disease: Moderate global developmental delay
Moderate global developmental delay 		0.100 Biomarker phenotype HPO
CUI: C2673443
Disease: Hypermagnesiuria
Hypermagnesiuria 		0.100 Biomarker phenotype HPO
CUI: C3278923
Disease: Dilated ventricles (finding)
Dilated ventricles (finding) 		0.100 Biomarker phenotype HPO
CUI: C4552811
Disease: Generalized Muscle Weakness, CTCAE
Generalized Muscle Weakness, CTCAE 		0.100 Biomarker phenotype HPO
CUI: C4552839
Disease: Hypomagnesemia, CTCAE
Hypomagnesemia, CTCAE 		0.100 Biomarker phenotype HPO
CUI: C0022680
Disease: Polycystic Kidney Diseases
Polycystic Kidney Diseases 		0.020 Biomarker group BEFREE <b>Abbreviations:</b> ADPKD: Autosomal dominant polycystic kidney disease; <i>CFTR</i>: Cystic fibrosis transmembrane conductance regulator; <i>EGF</i>: Epidermal growth factor; MCIC: Mayo Clinic Imaging Classification; PKD: Polycystic kidney disease; <i>TSC2</i>: Tuberous sclerosis complex 2. 31488014 2019
CUI: C0041341
Disease: Tuberous Sclerosis
Tuberous Sclerosis 		0.020 Biomarker disease BEFREE <b>Abbreviations:</b> ADPKD: Autosomal dominant polycystic kidney disease; <i>CFTR</i>: Cystic fibrosis transmembrane conductance regulator; <i>EGF</i>: Epidermal growth factor; MCIC: Mayo Clinic Imaging Classification; PKD: Polycystic kidney disease; <i>TSC2</i>: Tuberous sclerosis complex 2. 31488014 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 Biomarker phenotype BEFREE <b>Conclusion:</b> In summary, we confirmed that EGF-Grb2-DENND1A-Rab35 signaling pathway with the interaction of DENND1A and Grb2 as a regulatory center could regulate gastric cancer cell migration and invasion. 30524285 2018
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE <b>Conclusion:</b> MiR-145 inhibits EGF-induced EMT via targeting Smad2 in human GBM. 31114250 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE <b>Introduction</b>: Cancer immunotherapy has revolutionized the treatment of patients with advanced or metastatic non-small cell lung cancer (NSCLC).However, specific patient groups (e.g. patients with activating <i>epidermal growth factor receptor</i> [<i>EGFR]</i> mutations) do not appear to derive benefit from immune checkpoint inhibitor (ICI) monotherapy. 31829747 2020