|
Periapical Periodontitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Expression of WNT3, WNT3A and WNT5A in AP tissues was significantly higher than in control tissues, and inversely correlated with the expression of SERPINB1, COL1A1 and TIMP1 (P < 0.05).
|
31831777 |
2019 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, we sought to characterize the role of SERPINB1 in prostate cancer.
|
30610107 |
2019 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, we sought to characterize the role of SERPINB1 in prostate cancer.
|
30610107 |
2019 |
|
Periapical Periodontitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression of HSP27 and SERPINB1 was ∼2-fold higher in apical periodontitis.
|
28673495 |
2017 |
|
Virus Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Additionally, the expression of the JA-regulated defense gene PI-II in tomato plants was repressed by virus infection.
|
28373670 |
2017 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression levels of CLMN, SERPINB1, and KLK6 are associated with prolonged relapse-free survival for breast cancer patients.
|
26485663 |
2016 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
We evidenced for the first time the dysregulation of 9 proteins (CSNK1A1, ARID5B, LYPLA1, PSMB6, RABEP1, TALDO1, UBE2N, PPP1CB, and SERPINB1) that may have role in PCa.
|
26074449 |
2015 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We evidenced for the first time the dysregulation of 9 proteins (CSNK1A1, ARID5B, LYPLA1, PSMB6, RABEP1, TALDO1, UBE2N, PPP1CB, and SERPINB1) that may have role in PCa.
|
26074449 |
2015 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our data suggest that SERPINB1 negatively regulates glioma cell migration and invasion probably by abrogating the expression of MMP-2 and the activation of FAK.
|
24968089 |
2015 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Recent studies suggested that SERPINB1 may suppress the migration and invasion of lung and breast cancers.
|
24105272 |
2014 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
SERPINB1 was downregulated in HCC specimens and correlatively related with two clinicopathologic features of HCC, metastasis (P = 0.000) and vein invasion (P = 0.006).
|
24105272 |
2014 |
|
Virus Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Previously, we demonstrated that serpinb1-deficient mice are highly susceptible to pulmonary bacterial and viral infections due to inflammation and tissue injury associated with increased neutrophilic death.
|
23002442 |
2012 |
|
Aniridia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on the resulting filtered gene list, qPCR primers were purchased, and candidate genes (TP63, ABCG2, ADH7, ALDH1A1, PITX1, DKK1, DSG1, KRT12, KRT3, KRT13, SPINK6, SPINK7, CTSV, SERPINB1) were verified by qPCR on the siRNA-based aniridia cell model.
|
30292490 |
2019 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
We concluded that MNEI could represent a valid alternative to fructose, particularly when concomitant metabolic disorders such as diabetes and/or glucose intolerance are present.
|
31689911 |
2019 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
We concluded that MNEI could represent a valid alternative to fructose, particularly when concomitant metabolic disorders such as diabetes and/or glucose intolerance are present.
|
31689911 |
2019 |
|
Leukopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia.
|
30843084 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Four proteins were significantly different between PMA-NETs from RA and SLE neutrophils (<i>p</i> < 0.05): RNASE2 was higher in RA, whereas MPO, leukocyte elastase inhibitor and thymidine phosphorylase were higher in SLE.
|
30915077 |
2019 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We concluded that MNEI could represent a valid alternative to fructose, particularly when concomitant metabolic disorders such as diabetes and/or glucose intolerance are present.
|
31689911 |
2019 |
|
Neutropenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia.
|
30843084 |
2019 |
|
Prostatic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
SERPINB1 is also reduced in <i>Pten</i>-null mouse prostate tumors compared with wild-type prostates, and treatment with sivelestat (SERPINB1 pharmacomimetic) attenuates tumor growth.
|
30610107 |
2019 |
|
Cohen syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, a striking decrease in the expression of SERPINB1 gene, which encodes a critical component of neutrophil survival, was detected in CS neutrophils.
|
30843084 |
2019 |
|
Impaired glucose tolerance
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We concluded that MNEI could represent a valid alternative to fructose, particularly when concomitant metabolic disorders such as diabetes and/or glucose intolerance are present.
|
31689911 |
2019 |
|
Endotoxemia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Consequently, knockdown or deletion of SERPINB1 prompted spontaneous activation of caspase-1/-4/-5/-11, release of the cytokine IL-1β and pyroptosis, inducing elevated inflammation after non-hygienic co-housing with pet-store mice and enhanced sensitivity to lipopolysaccharide- or Acinetobacter baumannii-induced endotoxemia.
|
30692621 |
2019 |
|
Spondylarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The objective of the present work was to compare the correlation of three enthesitis indices (MASES, SPARCC and LEI) with measures of disease activity and function in a heterogeneous population of patients with axial and peripheral SpA.
|
31208465 |
2019 |
|
Enthesitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective of the present work was to compare the correlation of three enthesitis indices (MASES, SPARCC and LEI) with measures of disease activity and function in a heterogeneous population of patients with axial and peripheral SpA.
|
31208465 |
2019 |