Malignant neoplasm of prostate
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Recently, a SLC45A3-ELK4 chimera has been shown to be androgen-regulated, and is overexpressed in metastatic or high-grade prostate tumors relative to local prostate cancers.
|
20406994 |
2010 |
Malignant neoplasm of prostate
|
0.060 |
Biomarker
|
disease |
BEFREE |
This fusion RNA, SLC45A3-ELK4, generated by cis-splicing between neighboring genes, was found in prostate cancer.
|
28716526 |
2017 |
Malignant neoplasm of prostate
|
0.060 |
Biomarker
|
disease |
BEFREE |
The chimeric transcript, but not wild-type ELK4, is shown to augment prostate cancer cell proliferation.
|
22787087 |
2012 |
Malignant neoplasm of prostate
|
0.060 |
Biomarker
|
disease |
BEFREE |
Several studies have assessed the rearrangement status of the most commonly found ETS rearranged gene ERG, and the less frequent genes, ETV-1, ETV-4, ETV-5, and ELK-4 in primary prostate cancer.
|
22569213 |
2012 |
Malignant neoplasm of prostate
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
With the absence of corresponding DNA rearrangement, chimeric fusion SLC45A3-ELK4 transcript in prostate cancer cells is generated by cis-splicing of adjacent genes/gene read-through instead of trans-splicing.
|
22719019 |
2012 |
Malignant neoplasm of prostate
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
SLC45A3-ELK4 transcript can be detected at high levels in urine samples from men at risk for prostate cancer.
|
19293179 |
2009 |
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Several studies have assessed the rearrangement status of the most commonly found ETS rearranged gene ERG, and the less frequent genes, ETV-1, ETV-4, ETV-5, and ELK-4 in primary prostate cancer.
|
22569213 |
2012 |
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The chimeric transcript, but not wild-type ELK4, is shown to augment prostate cancer cell proliferation.
|
22787087 |
2012 |
Prostate carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
With the absence of corresponding DNA rearrangement, chimeric fusion SLC45A3-ELK4 transcript in prostate cancer cells is generated by cis-splicing of adjacent genes/gene read-through instead of trans-splicing.
|
22719019 |
2012 |
Prostate carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
SLC45A3-ELK4 transcript can be detected at high levels in urine samples from men at risk for prostate cancer.
|
19293179 |
2009 |
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
This fusion RNA, SLC45A3-ELK4, generated by cis-splicing between neighboring genes, was found in prostate cancer.
|
28716526 |
2017 |
Oral candidiasis
|
0.020 |
Biomarker
|
disease |
BEFREE |
SAP1 and SAP3 transcripts were observed only in patients with oral candidiasis.
|
10225911 |
1999 |
Oral candidiasis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Expression of SAP1-3 and 6 was also detected by RT-PCR in samples from patients suffering from oral candidosis.
|
9720876 |
1998 |
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We here show for the first time that the most common genomic copy number gains in breast cancer, 1q21 and 1q32, are associated with overexpression of the ETS transcription factors ETV3 and ELF3 (but not ELK4) at these loci irrespective of molecular subtypes.
|
23329352 |
2013 |
Candidiasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
C. albicans SC5314 SAP1-10 gene expression was monitored in organotypic reconstituted human epithelium (RHE) models, monolayers of oral epithelial cells, and patients with oral (n=17) or vaginal (n=17) candidiasis.
|
18957581 |
2008 |
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we show that SAP-1 ablation in interleukin (IL)-10-deficient mice, a model of inflammatory bowel disease, resulted in a marked increase in the severity of colitis in association with up-regulation of mRNAs for various cytokines and chemokines in the colon.
|
26195794 |
2015 |
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In total, 14 DEMs were found in CRC.By bioinformatics analysis, 5 DEMs (miR-145, miR-497, miR-30a, miR-31, and miR-20a) and 8 TFs (ELK4 (ETS-family transcription factor), myeloblastosis proto-oncogene like (MYBL)1, MYBL2, CEBPA, PPARA, PPARD, PPARG, and endothelial PAS domain protein (EPAS1)) appeared to be associated with CRC and were therefore used to construct miRNA-TF-gene networks.
|
30985693 |
2019 |
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, in vivo, ELK4 downregulation reduced tumor formation in glioblastoma xenograft models.
|
21846680 |
2011 |
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The critical role of ELK4 in Mcl-1 expression and protection from apoptosis in glioma defines ELK4 as a novel potential therapeutic target for GBM.
|
21846680 |
2011 |
Hepatitis B
|
0.010 |
Biomarker
|
disease |
BEFREE |
The amplified HBV DNA fragments were inserted into pHY106 vectors by Sap I digestion.
|
18567076 |
2008 |
Leukodystrophy, Metachromatic
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mechanism for a 33-nucleotide insertion in mRNA causing sphingolipid activator protein (SAP-1)-deficient metachromatic leukodystrophy.
|
2066109 |
1991 |
Leukoencephalopathy, Progressive Multifocal
|
0.010 |
Biomarker
|
disease |
BEFREE |
It could be shown that the basic structures of the regulatory regions are similar between Sap-1 and isolates from cerebral PML.
|
1313631 |
1992 |
Malaria
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Targeted deletion of SAP1 in the rodent malaria parasite Plasmodium yoelii generated mutant parasites that traverse and invade hepatocytes normally but cannot initiate liver-stage development in vitro and in vivo.
|
18466298 |
2008 |
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among 72 polymerase chain reaction clones, one of the cDNA sequences encoded a novel potential PTP (stomach cancer-associated PTP, SAP-1).
|
8294459 |
1994 |
melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, ELK4 is overexpressed in melanoma and knocking down the ELK4 or CDK2 expression significantly attenuated the malignant phenotype of melanoma cells.
|
26028036 |
2016 |