ELK4, ETS transcription factor ELK4, 2005

N. diseases: 32; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023524
Disease: Leukoencephalopathy, Progressive Multifocal
Leukoencephalopathy, Progressive Multifocal 		0.010 Biomarker disease BEFREE It could be shown that the basic structures of the regulatory regions are similar between Sap-1 and isolates from cerebral PML. 1313631 1992
CUI: C0023522
Disease: Leukodystrophy, Metachromatic
Leukodystrophy, Metachromatic 		0.010 Biomarker disease BEFREE The mechanism for a 33-nucleotide insertion in mRNA causing sphingolipid activator protein (SAP-1)-deficient metachromatic leukodystrophy. 2066109 1991
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 Biomarker disease BEFREE Among 72 polymerase chain reaction clones, one of the cDNA sequences encoded a novel potential PTP (stomach cancer-associated PTP, SAP-1). 8294459 1994
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 Biomarker disease BEFREE Among 72 polymerase chain reaction clones, one of the cDNA sequences encoded a novel potential PTP (stomach cancer-associated PTP, SAP-1). 8294459 1994
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.010 Biomarker group BEFREE Isolates of Candida albicans from the oral cavities of subjects at different stages of human immunodeficiency virus (HIV) infection or uninfected controls were examined for (i) production of aspartic proteinase(s), a putative virulence-associated factor(s); (ii) the presence in the fungal genome of two major genes (SAP1 and SAP2) of the aspartic proteinase family; and (iii) experimental pathogenicity in a murine model of systemic infection. 8550193 1996
CUI: C0243026
Disease: Sepsis
Sepsis 		0.010 Biomarker disease BEFREE Isolates of Candida albicans from the oral cavities of subjects at different stages of human immunodeficiency virus (HIV) infection or uninfected controls were examined for (i) production of aspartic proteinase(s), a putative virulence-associated factor(s); (ii) the presence in the fungal genome of two major genes (SAP1 and SAP2) of the aspartic proteinase family; and (iii) experimental pathogenicity in a murine model of systemic infection. 8550193 1996
CUI: C0006849
Disease: Oral candidiasis
Oral candidiasis 		0.020 AlteredExpression disease BEFREE Expression of SAP1-3 and 6 was also detected by RT-PCR in samples from patients suffering from oral candidosis. 9720876 1998
CUI: C0006849
Disease: Oral candidiasis
Oral candidiasis 		0.020 Biomarker disease BEFREE SAP1 and SAP3 transcripts were observed only in patients with oral candidiasis. 10225911 1999
CUI: C0404521
Disease: Infective vaginitis
Infective vaginitis 		0.010 Biomarker disease BEFREE These data provide further evidence for a crucial role of Sap1 and Sap2 in C. albicans vaginal infections. 12761103 2003
CUI: C0700345
Disease: Candidiasis, Vulvovaginal
Candidiasis, Vulvovaginal 		0.010 Biomarker disease BEFREE SAP 1 and SAP 3 transcripts were observed only in patients with VVC and RVVC. 17714358 2007
CUI: C0024530
Disease: Malaria
Malaria 		0.010 GeneticVariation disease BEFREE Targeted deletion of SAP1 in the rodent malaria parasite Plasmodium yoelii generated mutant parasites that traverse and invade hepatocytes normally but cannot initiate liver-stage development in vitro and in vivo. 18466298 2008
CUI: C1112211
Disease: Hepatic Infection
Hepatic Infection 		0.010 Biomarker disease BEFREE These findings demonstrate that SAP1 is essential for liver infection possibly by functioning as a selective regulator controlling the expression of infectivity-associated parasite effector genes. 18466298 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.020 AlteredExpression group LHGDN Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells. 18469865 2008
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.010 Biomarker disease BEFREE The amplified HBV DNA fragments were inserted into pHY106 vectors by Sap I digestion. 18567076 2008
CUI: C0006840
Disease: Candidiasis
Candidiasis 		0.010 AlteredExpression disease BEFREE C. albicans SC5314 SAP1-10 gene expression was monitored in organotypic reconstituted human epithelium (RHE) models, monolayers of oral epithelial cells, and patients with oral (n=17) or vaginal (n=17) candidiasis. 18957581 2008
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.060 AlteredExpression disease BEFREE SLC45A3-ELK4 transcript can be detected at high levels in urine samples from men at risk for prostate cancer. 19293179 2009
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.050 AlteredExpression disease BEFREE SLC45A3-ELK4 transcript can be detected at high levels in urine samples from men at risk for prostate cancer. 19293179 2009
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.060 AlteredExpression disease BEFREE Recently, a SLC45A3-ELK4 chimera has been shown to be androgen-regulated, and is overexpressed in metastatic or high-grade prostate tumors relative to local prostate cancers. 20406994 2010
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.020 AlteredExpression group BEFREE Recently, a SLC45A3-ELK4 chimera has been shown to be androgen-regulated, and is overexpressed in metastatic or high-grade prostate tumors relative to local prostate cancers. 20406994 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 AlteredExpression group BEFREE Furthermore, in vivo, ELK4 downregulation reduced tumor formation in glioblastoma xenograft models. 21846680 2011
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.010 AlteredExpression disease BEFREE Furthermore, in vivo, ELK4 downregulation reduced tumor formation in glioblastoma xenograft models. 21846680 2011
CUI: C0017638
Disease: Glioma
Glioma 		0.010 Biomarker disease BEFREE The critical role of ELK4 in Mcl-1 expression and protection from apoptosis in glioma defines ELK4 as a novel potential therapeutic target for GBM. 21846680 2011
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.010 AlteredExpression disease BEFREE Furthermore, in vivo, ELK4 downregulation reduced tumor formation in glioblastoma xenograft models. 21846680 2011
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.010 AlteredExpression disease BEFREE Furthermore, in vivo, ELK4 downregulation reduced tumor formation in glioblastoma xenograft models. 21846680 2011
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.010 Biomarker disease BEFREE The critical role of ELK4 in Mcl-1 expression and protection from apoptosis in glioma defines ELK4 as a novel potential therapeutic target for GBM. 21846680 2011