ELK4, ETS transcription factor ELK4, 2005

N. diseases: 32; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.060 AlteredExpression disease BEFREE Recently, a SLC45A3-ELK4 chimera has been shown to be androgen-regulated, and is overexpressed in metastatic or high-grade prostate tumors relative to local prostate cancers. 20406994 2010
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.060 Biomarker disease BEFREE This fusion RNA, SLC45A3-ELK4, generated by cis-splicing between neighboring genes, was found in prostate cancer. 28716526 2017
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.060 Biomarker disease BEFREE The chimeric transcript, but not wild-type ELK4, is shown to augment prostate cancer cell proliferation. 22787087 2012
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.060 Biomarker disease BEFREE Several studies have assessed the rearrangement status of the most commonly found ETS rearranged gene ERG, and the less frequent genes, ETV-1, ETV-4, ETV-5, and ELK-4 in primary prostate cancer. 22569213 2012
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.060 AlteredExpression disease BEFREE With the absence of corresponding DNA rearrangement, chimeric fusion SLC45A3-ELK4 transcript in prostate cancer cells is generated by cis-splicing of adjacent genes/gene read-through instead of trans-splicing. 22719019 2012
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.060 AlteredExpression disease BEFREE SLC45A3-ELK4 transcript can be detected at high levels in urine samples from men at risk for prostate cancer. 19293179 2009
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.050 Biomarker disease BEFREE Several studies have assessed the rearrangement status of the most commonly found ETS rearranged gene ERG, and the less frequent genes, ETV-1, ETV-4, ETV-5, and ELK-4 in primary prostate cancer. 22569213 2012
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.050 Biomarker disease BEFREE The chimeric transcript, but not wild-type ELK4, is shown to augment prostate cancer cell proliferation. 22787087 2012
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.050 AlteredExpression disease BEFREE With the absence of corresponding DNA rearrangement, chimeric fusion SLC45A3-ELK4 transcript in prostate cancer cells is generated by cis-splicing of adjacent genes/gene read-through instead of trans-splicing. 22719019 2012
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.050 AlteredExpression disease BEFREE SLC45A3-ELK4 transcript can be detected at high levels in urine samples from men at risk for prostate cancer. 19293179 2009
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.050 Biomarker disease BEFREE This fusion RNA, SLC45A3-ELK4, generated by cis-splicing between neighboring genes, was found in prostate cancer. 28716526 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 GeneticVariation group BEFREE The strongest signal maps to a transcriptional enhancer element in which the G allele of the best candidate causative variant rs554219 increases risk of breast cancer, reduces both binding of ELK4 transcription factor and luciferase activity in reporter assays, and may be associated with low cyclin D1 protein levels in tumors. 23540573 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 AlteredExpression group BEFREE Tumor expression of neither ELK3 nor ELK4 was associated with disease-free survival (DFS). 31794091 2020
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 AlteredExpression group BEFREE Furthermore, in vivo, ELK4 downregulation reduced tumor formation in glioblastoma xenograft models. 21846680 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker group BEFREE Altogether, these results indicate that SLC45A3-ELK4 regulates cancer cell proliferation by its transcript, not translated protein. 28716526 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 AlteredExpression group BEFREE Although the expression level of SLC45A3-ELK4 is higher in cancer than normal cells, and a dramatic increase in its expression from normal to cancer cells is correlated with advanced disease, its expression level in cancer samples alone is not correlated with any clinical parameters. 25188740 2014
CUI: C0006849
Disease: Oral candidiasis
Oral candidiasis 		0.020 Biomarker disease BEFREE SAP1 and SAP3 transcripts were observed only in patients with oral candidiasis. 10225911 1999
CUI: C0006849
Disease: Oral candidiasis
Oral candidiasis 		0.020 AlteredExpression disease BEFREE Expression of SAP1-3 and 6 was also detected by RT-PCR in samples from patients suffering from oral candidosis. 9720876 1998
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.020 AlteredExpression group BEFREE Recently, a SLC45A3-ELK4 chimera has been shown to be androgen-regulated, and is overexpressed in metastatic or high-grade prostate tumors relative to local prostate cancers. 20406994 2010
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression group BEFREE Although the expression level of SLC45A3-ELK4 is higher in cancer than normal cells, and a dramatic increase in its expression from normal to cancer cells is correlated with advanced disease, its expression level in cancer samples alone is not correlated with any clinical parameters. 25188740 2014
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 Biomarker group BEFREE Altogether, these results indicate that SLC45A3-ELK4 regulates cancer cell proliferation by its transcript, not translated protein. 28716526 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 AlteredExpression disease BEFREE We here show for the first time that the most common genomic copy number gains in breast cancer, 1q21 and 1q32, are associated with overexpression of the ETS transcription factors ETV3 and ELF3 (but not ELK4) at these loci irrespective of molecular subtypes. 23329352 2013
CUI: C0006840
Disease: Candidiasis
Candidiasis 		0.010 AlteredExpression disease BEFREE C. albicans SC5314 SAP1-10 gene expression was monitored in organotypic reconstituted human epithelium (RHE) models, monolayers of oral epithelial cells, and patients with oral (n=17) or vaginal (n=17) candidiasis. 18957581 2008
CUI: C0009319
Disease: Colitis
Colitis 		0.010 Biomarker disease BEFREE Here we show that SAP-1 ablation in interleukin (IL)-10-deficient mice, a model of inflammatory bowel disease, resulted in a marked increase in the severity of colitis in association with up-regulation of mRNAs for various cytokines and chemokines in the colon. 26195794 2015
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 AlteredExpression disease BEFREE In total, 14 DEMs were found in CRC.By bioinformatics analysis, 5 DEMs (miR-145, miR-497, miR-30a, miR-31, and miR-20a) and 8 TFs (ELK4 (ETS-family transcription factor), myeloblastosis proto-oncogene like (MYBL)1, MYBL2, CEBPA, PPARA, PPARD, PPARG, and endothelial PAS domain protein (EPAS1)) appeared to be associated with CRC and were therefore used to construct miRNA-TF-gene networks. 30985693 2019