Aortic Aneurysm, Abdominal
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It was shown that CYP2J2 overexpression attenuated matrix metalloproteinase expression and activity, elastin degradation, and AAA formation, which was associated with reduced aortic inflammation and macrophage infiltration.
|
23446230 |
2013 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
A2AR activation attenuates AAA formation partly by inhibiting immune cell recruitment and reducing elastin fragmentation.
|
23413358 |
2013 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The combination therapy significantly reduced AngII-induced apoptosis and elastin degradation at the AAA lesion, whereas each monotherapy did not.
|
23967318 |
2013 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that polymorphisms in MMP2, MMP3, MMP-13, and ELN genes may independently contribute to the pathogenesis of AAA.
|
22094117 |
2012 |
Aortic Aneurysm, Abdominal
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CatK deficiency significantly reduced lesion CD4(+) T-cell content, total lesion and medial cell proliferation and apoptosis, medial smooth muscle cell (SMC) loss, elastinolytic CatL and CatS expression, and elastin fragmentation, but it did not affect AAA lesion Mac-3(+) macrophage accumulation or CD31(+) microvessel numbers.
|
21817099 |
2012 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Infusion of angiotensin II (Ang II) using micro-osmotic (Alzet) pumps in Timp3(-/-) male mice, but not in wild type control mice, led to adverse remodeling of the abdominal aorta, reduced collagen and elastin proteins but not mRNA, and elevated proteolytic activities, suggesting excess protein degradation within 2 weeks that led to formation of AAA by 4 weeks.
|
23144462 |
2012 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The development of atherosclerotic lesions and abdominal aortic aneurysms involves degradation and loss of extracellular matrix components, such as collagen and elastin.
|
21726534 |
2011 |
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Abdominal aortic aneurysms (AAA) are characterized by structural alterations of the aortic wall resulting from the degradation of elastic fibres and an increase of collagen/elastin ratio.
|
20725971 |
2010 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
AAA lesions in Mcpt4(-/-) mice had fewer inflammatory cells and less apoptosis, angiogenesis, and elastin fragmentation than those of WT mice.
|
19720934 |
2009 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
These studies demonstrate that destruction of the elastin fiber network during AAA formation is dependent on macrophage-derived MT1-MMP, which unexpectedly serves as a direct-acting regulator of macrophage proteolytic activity.
|
19010778 |
2009 |
Aortic Aneurysm, Abdominal
|
0.400 |
Therapeutic
|
disease |
RGD |
AdTE-GFP transfection reversed AAA formation (mean +/- standard error), with the controls showing increased ADs (a 48.50 +/- 16.55% increase for the PBS perfusion group and a 39.84 +/- 15.59% increase for the AdNull treated group) and the AdTE-GFP transfected group showing a decreased AD (23.04 +/- 14.49%, P < .01).
|
18585885 |
2008 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The growth of the AAA is dependent on proteolytic degradation of elastin.
|
17721627 |
2007 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The development of AAA is linked to degradation of elastin and collagen.
|
17182929 |
2006 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
As matrix degradation contributes to the progression of AAA, the destruction and degradation of elastin fibers caused by an increase in matrix metalloproteinases (MMPs) plays a pivotal role in the development of AAA.
|
15800662 |
2005 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, we found a significant interaction between the polymorphism and gender for MMP10 ( P = .037) in cases without a family history of AAA, as well as between the polymorphism and country of origin for ELN ( P = .0169) and TIMP3 ( P = .0023) in cases with a family history of AAA.
|
15944607 |
2005 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Abdominal aortic aneurysm (AAA) is characterized by dilatation of arterial walls, which is accompanied by degradation of elastin and collagen molecules.
|
16127278 |
2005 |
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, polymorphisms of ELN, estrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor (PR) and TGFbeta1 genes and their products may be involved in the abdominal aortic aneurysm (AAA) development.
|
15698546 |
2004 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Degradation of the extracellular matrix components elastin and collagen has been implicated in vascular diseases, including abdominal aortic aneurysm (AAA) and atherosclerotic plaque rupture.
|
14681644 |
2003 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human AAA and atheroma have 4- to 6-fold more tropoelastin protein than nondiseased arteries.
|
12615674 |
2003 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Histological examination revealed fragmentation of elastin fibers within venous tissue obtained from patients with AAA and a significant depletion of the elastin within the media.
|
11457749 |
2001 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The evolution of AAAs is thought to involve the progressive degradation of aortic wall elastin and collagen, and increased local production of several matrix metallo-proteinases (MMPs) has been implicated in this process.
|
10415728 |
1999 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Degradation of extracellular matrix, especially elastin, within the aortic wall is a hallmark of abdominal aortic aneurysms (AAAs).
|
9588507 |
1998 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The decreased elastin concentration relative to collagen in AAAs may be explained, in part, by the changes in message level of elastin and collagen.
|
1641765 |
1992 |
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aortic walls of patients with abdominal aortic aneurysms (AAA) and of healthy controls were examined for elastin, collagen I and III, and the intermediate filament proteins desmin and vimentin by immunohistochemical, enzyme histochemical, and routine histological techniques.
|
3539908 |
1986 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
HPO |
|
|
|