|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) has a characteristic chimeric oncogene EWS-FLI1, which results from chromosomal translocation t (11; 22), that is believed to initiate tumorigenesis of EWS/PNET.
|
18622580 |
2008 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing's sarcoma and peripheral primitive neuroectodermal tumour (pPNET) are now regarded as two morphological ends of a spectrum of neoplasms, characterised by a t(11;22) or other related chromosomal translocation involving the EWS gene on chromosome 22 and referred to as Ewing family of tumours (EFTs).
|
17557870 |
2007 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma/peripheral neuroectodermal tumor (EWS/PNET), since its characterization immunophenotypically and cytogenetically, has emerged as one of most common sarcomas of childhood.
|
17487851 |
2007 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
RT-PCR to detect EWS-ETS gene arrangements is widely used to confirm the diagnosis of Ewing's family of tumors.
|
17272319 |
2007 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) indicated a rearrangement of the EWS region on chromosome 22, which is highly specific for Ewing's sarcoma and PNET, which are referred to as the Ewing's sarcoma family of tumors (EFT).
|
17610475 |
2007 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma/primitive neuroectodermal tumor (EWS/PNET) is a diagnostically challenging malignant round cell tumor with signature translocations involving the EWS gene.
|
16258512 |
2006 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
This case is unusual in the sense of showing the typical gene fusion for pPNET/EWS both in the pretherapy sample with the typical morphological appearance of this tumor and in the posttherapy specimen showing neural differentiation suggestive of a neuroblastoma.
|
16944972 |
2006 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma/primitive neuroectodermal tumor (EWS/PNET) of the kidney is a rare and aggressive tumor.
|
17126256 |
2006 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pathologic studies revealed an Ewing sarcoma/peripheral primitive neuroectodermal tumor (EWS/pPNET) with typical features including periodic acid Schiff positive diastase sensitive cytoplasmic substance; strong membranous pattern of immunoreactivity for CD99, and a reciprocal translocation of t(11;22)(q24;q12) that was demonstrated by fluorescent in situ hybridization (FISH).
|
16196395 |
2005 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is not a single condition, but a group of morphologically and clinically closely related disorders with similar molecular biology -- expression of tumor-specific chimeric oncoproteins through balanced chromosomal translocations involving the EWS gene -- often referred to as the Ewing family of tumors.
|
15877528 |
2005 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
To apply these molecular markers to commonly available archival materials, we evaluated the feasibility of detecting EWS-Ets including EWS-Fli1 and EWS-ERG fusion transcripts in paraffin-embedded tissues and its diagnostic value for detecting ES/pPNET.
|
16157025 |
2005 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors.
|
15930281 |
2005 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors.
|
14973077 |
2004 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, infection of neuroblastoma tumor cell lines with Ews/Fli-1 switches the differentiation program of neuroblastomas to Ewing's sarcoma/peripheral neuroectodermal tumors.
|
15492248 |
2004 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We retrospectively monitored tumor contamination in stem cell harvests from patients with Ewing family of tumors (EFT) all harboring the specific translocation EWS-FLI-1 that characterize these tumors.
|
15049010 |
2004 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymerase chain reaction and sequencing assessment showed the presence of EWS/FLI1 type 2 chimeric transcript, confirming the diagnosis of peripheral primitive neuroectodermal tumor.
|
12683899 |
2003 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma (ES) and peripheral primitive neuroectodermal tumors (PNETs) are associated with a chromosomal translocation resulting in a fusion of the amino-terminus of EWS with the DNA-binding domain of an ETS transcription factor (most commonly FLI1 or ERG).
|
12557222 |
2003 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
This case of PNET/EWS is unique in the sense of showing the typical fusion transcript associated with this tumor both in the morphologically typical pretherapy tumor and in the sample from the post-therapy specimen showing neuroblastoma-like features.
|
12883251 |
2003 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, however, it was reported that by using highly sensitive nested RT-PCR, a high proportion of GCT displays chimeric EWS/FLI1 fusion transcripts, i.e., the molecular genetic feature previously known to be strongly associated with the Ewing family of tumors.
|
11519035 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Virtually all cases of Ewing's Sarcoma and peripheral Primitive Neuroectodermal Tumor (PNET) are associated with aberrant transcription factors which fuse amino-terminal EWS with the DNA binding moiety of an ETS transcription factor (FLI-1 in 90% of cases).
|
11313995 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The method might also accurately diagnose ET-associated translocations other than EWS-FLI and EWS-ERG translocations.
|
11471459 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ewing sarcoma-primitive neuroectodermal tumor (EWS/PNET) belongs to the group of pediatric small round blue cell tumors; although EWS/PNET is classically a tumor of the soft tissue or bone in children and young adults, individual cases have been described in patients of all ages.
|
11679946 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All peripheral PNET tested expressed MIC2 and were positive for EWS-FLI1 (11/11).
|
11304041 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Primitive neuroectodermal tumor (PNET) is a prototypic malignant small round cell tumor of childhood that is characterized in most cases by t(11;22) resulting in an EWS-FLI1 gene fusion.
|
11178636 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the reverse transcriptase-polymerase chain reaction (RT-PCR) demonstrated EWS/FLI-1 fusion transcripts, confirming the histopathologic diagnosis of PNET.
|
11261815 |
2001 |