Ptosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Saethre-Chotzen syndrome (acrocephalo-syndactyly type III, ACS III) is an autosomal dominant craniosynostosis with brachydactyly, soft tissue syndactyly and facial dysmorphism including ptosis, facial asymmetry and prominent ear crura.
|
8988167 |
1997 |
Syndactyly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Saethre-Chotzen syndrome (acrocephalo-syndactyly type III, ACS III) is an autosomal dominant craniosynostosis with brachydactyly, soft tissue syndactyly and facial dysmorphism including ptosis, facial asymmetry and prominent ear crura.
|
8988167 |
1997 |
Brachydactyly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Saethre-Chotzen syndrome (acrocephalo-syndactyly type III, ACS III) is an autosomal dominant craniosynostosis with brachydactyly, soft tissue syndactyly and facial dysmorphism including ptosis, facial asymmetry and prominent ear crura.
|
8988167 |
1997 |
Childhood asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.
|
19221603 |
2009 |
Congenital anomaly of face
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Saethre-Chotzen syndrome (acrocephalo-syndactyly type III, ACS III) is an autosomal dominant craniosynostosis with brachydactyly, soft tissue syndactyly and facial dysmorphism including ptosis, facial asymmetry and prominent ear crura.
|
8988167 |
1997 |
Vascular calcification
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results identify ACSL3 and NF-κB as mediators of PA-induced osteoblastic differentiation and calcium deposition in VSMC and suggest that EPA prevents vascular calcification by inhibiting such a new molecular pathway elicited by PA.
|
23840832 |
2013 |
Congenital facial asymmetry
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Saethre-Chotzen syndrome (acrocephalo-syndactyly type III, ACS III) is an autosomal dominant craniosynostosis with brachydactyly, soft tissue syndactyly and facial dysmorphism including ptosis, facial asymmetry and prominent ear crura.
|
8988167 |
1997 |
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High ACSL3 expression predicted a better prognosis in ovarian cancer; in contrast, high ACSL3 predicted a worse prognosis in melanoma.
|
27171439 |
2016 |
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High ACSL3 expression predicted a better prognosis in ovarian cancer; in contrast, high ACSL3 predicted a worse prognosis in melanoma.
|
27171439 |
2016 |
Sarcoma
|
0.010 |
Biomarker
|
group |
BEFREE |
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
|
29450800 |
2018 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Among the five family isoforms, ACSL1 and ACSL4 are able to promote ungoverned cell growth, facilitate tumor invasion and evade programmed cell death, while ACSL3 may have relatively complex functions in different types of cancer.
|
30008815 |
2018 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Among the five family isoforms, ACSL1 and ACSL4 are able to promote ungoverned cell growth, facilitate tumor invasion and evade programmed cell death, while ACSL3 may have relatively complex functions in different types of cancer.
|
30008815 |
2018 |
Trichohepatoenteric Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
We describe an Italian family with ACS III in which two sibs are clearly affected; the mother and the maternal grandmother show some features of the syndrome.
|
4073118 |
1985 |
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells.
|
18003621 |
2008 |
Hormone sensitive prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A public database showed that ACSL3 level was higher in CRPC than in hormone-sensitive prostate cancer.
|
28771887 |
2017 |
Malignant neoplasm of soft tissue
|
0.010 |
Biomarker
|
group |
BEFREE |
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
|
29450800 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High ACSL3 expression predicted a better prognosis in ovarian cancer; in contrast, high ACSL3 predicted a worse prognosis in melanoma.
|
27171439 |
2016 |
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Influenza due to Influenza A virus subtype H1N1
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.
|
26379185 |
2015 |
Hepatitis C
|
0.010 |
Biomarker
|
disease |
LHGDN |
These results identify ACSL3 as a new enzymatic target to limit VLDL secretion and HCV infection.
|
18003621 |
2008 |
Hyperlipidemia
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation.
|
17761945 |
2007 |
Prostatic Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells.
|
15556626 |
2004 |
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Elevated expression of liver X receptor alpha (LXRα) in myocardium of streptozotocin-induced diabetic rats.
|
21136146 |
2011 |
Inflammation
|
0.200 |
Biomarker
|
phenotype |
RGD |
Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation.
|
14622223 |
2003 |