Pemphigus Foliaceus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The rs35336528 (OR = 3·44; P = 0·009) and rs1865097 (OR = 0·57; P = 0·005) SNPs in LENG8 and FCAR genes, respectively, were also associated with PF.
|
30216441 |
2019 |
Acute respiratory infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Topical application of human-derived Ig isotypes for the control of acute respiratory infection evaluated in a human CD89-expressing mouse model.
|
31105268 |
2019 |
Nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although the molecular features of human IgA1 are different from rodent IgA, human IgA1 knock-in (α1KI)-CD89 transgenic mice, which express both human IgA1 and CD89, show circulating and mesangial deposits of IgA1-soluble CD89 complexes that result in kidney inflammation, hematuria, and proteinuria.
|
30177023 |
2018 |
Dermatitis Herpetiformis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A positive correlation was revealed between CD89 immunoexpression and anti-npG IgA in DH.
|
29417981 |
2017 |
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, a cream containing IgA or FcαRI peptide mimetics, which block IgA-induced neutrophil activation and migration in the skin may have therapeutic potential for patients with IgA-mediated blistering skin diseases.
|
28736835 |
2017 |
Lupus Nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Targeted IgA Fc receptor I (FcαRI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice.
|
25907714 |
2015 |
Kidney Failure, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Understanding how IgA triggers shedding of CD89 from myeloid cell surfaces could help clarify the process of immune complex formation in IgAN, and measurement of this soluble form of CD89 may in the future prove a useful prognostic indicator of end-stage renal disease in this common glomerulonephritis.
|
21116273 |
2010 |
Chronic kidney disease stage 5
|
0.010 |
Biomarker
|
disease |
BEFREE |
Understanding how IgA triggers shedding of CD89 from myeloid cell surfaces could help clarify the process of immune complex formation in IgAN, and measurement of this soluble form of CD89 may in the future prove a useful prognostic indicator of end-stage renal disease in this common glomerulonephritis.
|
21116273 |
2010 |
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
As such, we investigated whether IgA-Fc(alpha)RI interaction contributes to tissue damage in UC.
|
19555692 |
2009 |
Myeloid Leukemia, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Keeping in view the fact that a single acquired genetic abnormality "Bcr-Abl chimeric gene" accompanied by elevated telomerase activity has been widely recognized to be responsible for the leukemic myelopoiesis observed in chronic myeloid leukemia (CML), the present study was addressed to understand as to how selective and specific knock-down of human telomerase reverse transcriptase (hTERT) gene within mononuclear cells derived from untreated CML subjects could influence the apoptotic, genotypic (such as Bcr-Abl; C-myc; Bcl-2; IL-6; GMCSF; IL-3; and acetylated H(3) and H(4)), and phenotypic (such as CD34 and CD89) characteristics of these cells.
|
18409031 |
2008 |
Inflammation
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
These findings demonstrate that, on monomeric targeting, FcalphaRI functions as an FcRgamma ITAM-dependent apoptotic module that may be fundamental for controlling inflammation and tumor growth.
|
16990604 |
2007 |
Lupus Erythematosus, Systemic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings and the enrichment of the proinflammatory Gly(248)-FcalphaRI allele in systemic lupus erythematosus populations in two ethnic groups compared with their respective non-systemic lupus erythematosus controls suggest that FcalphaRI (CD89) alpha-chain alleles may affect receptor-mediated signaling and play an important role in the modulation of immune responses in inflammatory diseases.
|
17339498 |
2007 |
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Asp92Asn polymorphism in the myeloid IgA Fc receptor is associated with myocardial infarction in two disparate populations: CARE and WOSCOPS.
|
17008591 |
2006 |
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that the FCAR promoter SNPs may be related to chronic HCV infection and disease progression in Japanese CHC, which might be explained by altered FcalphaR expression affecting IgA-mediated immune responses and/or IgA catabolism.
|
17033823 |
2006 |
Myocardial Infarction
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCAR Asp92Asn polymorphism is associated with risk of MI and that this risk would be modified by pravastatin.
|
17008591 |
2006 |
Myocardial Infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCAR Asp92Asn polymorphism is associated with risk of MI and that this risk would be modified by pravastatin.
|
17008591 |
2006 |
Hepatitis C, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients.
|
17033823 |
2006 |
Hepatitis C, Chronic
|
0.010 |
Biomarker
|
disease |
LHGDN |
Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients.
|
17033823 |
2006 |
Pseudohyperkalemia Cardiff
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that the FCAR promoter SNPs may be related to chronic HCV infection and disease progression in Japanese CHC, which might be explained by altered FcalphaR expression affecting IgA-mediated immune responses and/or IgA catabolism.
|
17033823 |
2006 |
Infection
|
0.010 |
Biomarker
|
group |
LHGDN |
Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients.
|
17033823 |
2006 |
Acute periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A novel polymorphism of FcalphaRI (CD89) associated with aggressive periodontitis.
|
15140034 |
2004 |
Aggressive Periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A novel polymorphism of FcalphaRI (CD89) associated with aggressive periodontitis.
|
15140034 |
2004 |
Allergic asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, this is the first report on the distribution of 6 single nucleotide polymorphisms of the FCAR gene in a human population and the first study on FCAR polymorphism in allergic asthma.
|
15564774 |
2004 |
beta Thalassemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Otherwise, Hb Korea, CDs 89/90 -GT and a novel beta-thalassemia mutation, CD 131 CAG-->TAG, were only identified in Koreans.
|
12430907 |
2002 |
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Binding, internalization, and catabolic degradation of myeloma IgA1 protein as a standard control and the isolated CIC were studied using human MC, hepatoma cell line HepG2 expressing the asialoglycoprotein receptor (ASGP-R), and monocyte-like cell line U937 expressing the Fc(alpha)-R (CD89).
|
12110007 |
2002 |