FGF7, fibroblast growth factor 7, 2252

N. diseases: 167; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0235915
Disease: Pulmonary malformation
Pulmonary malformation 		0.020 AlteredExpression disease BEFREE Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung. 8618921 1995
CUI: C0009319
Disease: Colitis
Colitis 		0.010 Biomarker disease BEFREE Keratinocyte growth factor (KGF) stimulates gastrointestinal epithelial cells in vivo, and is protective against gastrointestinal injury and colitis. 10562583 1999
CUI: C0151971
Disease: Primary ulcer of intestine
Primary ulcer of intestine 		0.010 Biomarker disease BEFREE KGF-2 (0.3-5 mg/kg) was administered before or after induction of small intestinal ulceration by indomethacin (Indo) in prevention and treatment protocols. 11052999 2000
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 Biomarker phenotype BEFREE KGF is implicated in wound healing, healing lung injuries and tumorigenesis of various cancers such as breast and prostate. 12606136 2003
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Keratinocyte growth factor produced by gastric fibroblasts specifically stimulates proliferation of cancer cells from scirrhous gastric carcinoma. 14695201 2003
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE Keratinocyte growth factor produced by gastric fibroblasts specifically stimulates proliferation of cancer cells from scirrhous gastric carcinoma. 14695201 2003
CUI: C0857002
Disease: Scirrhous gastric carcinoma
Scirrhous gastric carcinoma 		0.010 Biomarker disease BEFREE Keratinocyte growth factor produced by gastric fibroblasts specifically stimulates proliferation of cancer cells from scirrhous gastric carcinoma. 14695201 2003
CUI: C0038362
Disease: Stomatitis
Stomatitis 		0.060 Biomarker disease BEFREE KGF is currently being evaluated in clinical trials to test its ability to ameliorate severe oral mucositis (OM) that results from cancer chemoradiotherapy. 15327889 2004
CUI: C1568868
Disease: Oral Mucositis
Oral Mucositis 		0.060 Biomarker disease BEFREE KGF is currently being evaluated in clinical trials to test its ability to ameliorate severe oral mucositis (OM) that results from cancer chemoradiotherapy. 15327889 2004
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE KGF is currently being evaluated in clinical trials to test its ability to ameliorate severe oral mucositis (OM) that results from cancer chemoradiotherapy. 15327889 2004
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE KGF is currently being evaluated in clinical trials to test its ability to ameliorate severe oral mucositis (OM) that results from cancer chemoradiotherapy. 15327889 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 Biomarker group BEFREE Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors. 15562028 2005
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema 		0.020 Biomarker disease BEFREE KGF production by emphysema fibroblasts (5.3 pg/mug, range of 2.2-9.3 pg/mug) was similar to that of controls at baseline (2.6 pg/mug, range of 1-6.1 pg/mug; P = 0.14) but could not be stimulated with interleukin-1beta. 15579628 2005
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.320 AlteredExpression disease BEFREE Keratinocyte growth factor expression by fibroblasts in pulmonary fibrosis: poor response to interleukin-1beta. 15677771 2005
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.030 Biomarker disease BEFREE FGF7-like gene is associated with pericentric inversion of chromosome 9, and FGF7 is involved in the development of ovarian cancer. 15809711 2005
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.030 Biomarker disease BEFREE FGF7-like gene is associated with pericentric inversion of chromosome 9, and FGF7 is involved in the development of ovarian cancer. 15809711 2005
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.030 Biomarker disease BEFREE FGF7-like gene is associated with pericentric inversion of chromosome 9, and FGF7 is involved in the development of ovarian cancer. 15809711 2005
CUI: C0085413
Disease: Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Autosomal Dominant 		0.010 AlteredExpression disease BEFREE KGF and KGFR protein expression was also higher in ADPKD cysts and was localized to cyst-lining epithelial cells, tubular and interstitial cells. 16141466 2005
CUI: C0010709
Disease: Cyst
Cyst 		0.010 AlteredExpression disease BEFREE KGF and KGFR protein expression was also higher in ADPKD cysts and was localized to cyst-lining epithelial cells, tubular and interstitial cells. 16141466 2005
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.040 Biomarker disease BEFREE KGF gene therapy mediated by attenuated Salmonella ameliorates ulcerative colitis induced by acetic acids, and it may be a safe and effective treatment for ulcerative colitis. 21677832 2011
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.030 AlteredExpression disease BEFREE Keratinocyte growth factor induces matrix metalloproteinase-9 expression and correlates with venous invasion in pancreatic cancer. 22159401 2012
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.030 AlteredExpression disease BEFREE Keratinocyte growth factor induces matrix metalloproteinase-9 expression and correlates with venous invasion in pancreatic cancer. 22159401 2012
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.020 Biomarker group BEFREE Keratinocyte growth factor (KGF), also known as fibroblast growth factor-7, and KGF receptor (KGFR) play important roles in the growth of epithelial cells and are overexpressed in a variety of malignant epithelial tumors, including pancreatic ductal adenocarcinoma (PDAC). 22159401 2012
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.320 AlteredExpression disease BEFREE Fibroblast growth factor 7 (FGF7) secreted from activated hepatic stellate cells (HSC) during chronic liver fibrosis regulates hepatocyte survival and liver regeneration. 22713451 2012
CUI: C1318485
Disease: Liver regeneration disorder
Liver regeneration disorder 		0.030 AlteredExpression phenotype BEFREE Fibroblast growth factor 7 (FGF7) secreted from activated hepatic stellate cells (HSC) during chronic liver fibrosis regulates hepatocyte survival and liver regeneration. 22713451 2012