FGF7, fibroblast growth factor 7, 2252

N. diseases: 167; N. variants: 6
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10519227
rs10519227
Entrez Id: 2252;196951
Gene Symbol: FGF7;FAM227B
FGF7;FAM227B
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement 		A 0.800 GeneticVariation GWASDB A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. 23408906 2013
dbSNP: rs10519227
rs10519227
Entrez Id: 2252;196951
Gene Symbol: FGF7;FAM227B
FGF7;FAM227B
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement 		A 0.800 GeneticVariation GWASCAT A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. 23408906 2013
dbSNP: rs17400427
rs17400427
Entrez Id: 2252;196951
Gene Symbol: FGF7;FAM227B
FGF7;FAM227B
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation GWASCAT Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. 28604730 2017
dbSNP: rs10519227
rs10519227
Entrez Id: 2252;196951
Gene Symbol: FGF7;FAM227B
FGF7;FAM227B
CUI: C0441683
Disease:
Hormone measurement 		A 0.700 GeneticVariation GWASCAT A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. 23408906 2013
dbSNP: rs372127537
rs372127537
Entrez Id: 2252;196951
Gene Symbol: FGF7;FAM227B
FGF7;FAM227B
CUI: C0399526
Disease:
Class III malocclusion 		0.010 GeneticVariation BEFREE The associations of common and rare variants with MP as a categorical phenotype and also continuous malocclusion phenotypes generated by principal component (PC) analysis were analyzed.One common variant, rs372127537, located in the 3'-untranslated region of FGF7 gene, was significantly related to PC1 (P  =  4.22 × 10), which explained 23.23% of the overall phenotypic variation observed and corresponded to vertical discrepancies ranging from short anterior face height to long anterior face height, after Bonferroni correction. 28640125 2017
dbSNP: rs372127537
rs372127537
Entrez Id: 2252;196951
Gene Symbol: FGF7;FAM227B
FGF7;FAM227B
CUI: C0024636
Disease:
Malocclusion 		0.010 GeneticVariation BEFREE The associations of common and rare variants with MP as a categorical phenotype and also continuous malocclusion phenotypes generated by principal component (PC) analysis were analyzed.One common variant, rs372127537, located in the 3'-untranslated region of FGF7 gene, was significantly related to PC1 (P  =  4.22 × 10), which explained 23.23% of the overall phenotypic variation observed and corresponded to vertical discrepancies ranging from short anterior face height to long anterior face height, after Bonferroni correction. 28640125 2017
dbSNP: rs10519225
rs10519225
Entrez Id: 2252;196951
Gene Symbol: FGF7;FAM227B
FGF7;FAM227B
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.010 GeneticVariation BEFREE The haplotype constructed by allele G at rs105</span>19225 and allele A at rs7170426 was associated with a decreased susceptibility to COPD (P=0.012, OR=0.751, FDR q=0.048). 22796760 2012
dbSNP: rs7170426
rs7170426
Entrez Id: 2252;196951
Gene Symbol: FGF7;FAM227B
FGF7;FAM227B
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.010 GeneticVariation BEFREE The haplotype constructed by allele G at rs10519225 and allele A at rs7170426 was associated with a decreased susceptibility to COPD (P=0.012, OR=0.751, FDR q=0.048). 22796760 2012
dbSNP: rs4480740
rs4480740
Entrez Id: 2252;196951
Gene Symbol: FGF7;FAM227B
FGF7;FAM227B
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.010 GeneticVariation BEFREE In a follow-up analysis, both SNPs (rs12591300 and rs4480740) were significantly associated with COPD in an independent population (combined p values of 7.9E-7 and 2.8E-6, respectively). 21921092 2011