|
Acute and chronic colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
ATX expression was increased upon induction of colitis, whereas ATX deletion reduced the severity of inflammation in both acute and chronic colitis, accompanied by transient weight loss.
|
30481488 |
2019 |
|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that SMG1 is a novel PC susceptibility gene, and we identified specific SMG1 gene variants associated with PC risk.
|
31469826 |
2019 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the role of C/EBPβ in PR-B expression regulation in glioblastoma cell lines, which expressed different ratios of PR and C/EBPβ isoforms (LAP1, LAP2, and LIP).
|
27663075 |
2017 |
|
Aqueous Humor Disorders
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Topical application of a small molecular chemical inhibitor of ATX (S32826), which inhibited AH LysoPLD activity in vitro (by >90%), led to a dose-dependent and significant decrease of IOP in Dutch-Belted rabbits.
|
22916143 |
2012 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conditional genetic ablation of ATX in mesenchymal cells, including SFs, resulted in disease attenuation in animal models of arthritis, establishing the ATX/LPA axis as a novel player in chronic inflammation and the pathogenesis of arthritis and a promising therapeutic target.
|
22493518 |
2012 |
|
Biliary Atresia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Subsequent analysis revealed that BA patients with advanced stage had lower methylation levels of ATX promoter than those with early stage.
|
28052132 |
2017 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Serum ATX as a novel biomarker for breast cancer.
|
30921203 |
2019 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.
|
19477432 |
2009 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In this work, we studied the effects of an ATX inhibitor, GLPG1690, which is in Phase 3 clinical trials for idiopathic pulmonary fibrosis, on responses to radiotherapy and chemotherapy in a syngeneic orthotopic mouse model of breast cancer.
|
31548293 |
2020 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Autotaxin (ATX, gene name: ENPP2) is a phospholipase with diverse roles in the physiological and pathological processes including inflammation and oncogenesis.
|
28126468 |
2017 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have demonstrated that SMG-1, a newly characterized member of the family of phosphatidylinositol 3-kinase-related protein kinases (PIKKs), is involved in tumorigenesis as a new tumor suppressor.
|
24700316 |
2014 |
|
Carcinogenesis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Altered expression of SMG-1 contributes to human carcinogenesis and cancer progression.
|
25760059 |
2015 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Our results reveal that endothelial ATX acts through LPA signaling to promote renal tumorigenesis and is functionally involved in the acquired resistance of RCC to sunitinib.
|
24122794 |
2013 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
SMG-1 inhibition by miR-192/-215 causes epithelial-mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling.
|
29239144 |
2018 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Western blot analysis confirmed C/EBPbeta expression in the ALK-positive ALCLs and demonstrated elevated levels of the LIP isoform, which has been associated with increased proliferation and aggressiveness in carcinomas.
|
16709933 |
2006 |
|
Carcinoma breast stage IV
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The study population consists of 188 women from the multicenter, randomised, phase II ATX trial (BOOG2006-06; EudraCT number 2006-006058-83) that received paclitaxel and bevacizumab without or with capecitabine as first-line palliative therapy of HER2-negative metastatic breast cancer.
|
27736846 |
2016 |
|
Carcinoma breast stage IV
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Increases in the ratio of LIP/LAP are associated with aggressive, metastatic breast cancer; however, little is known regarding the molecular mechanisms that regulate LIP expression or the biological actions of an increase in the LIP/LAP ratio.
|
21854628 |
2011 |
|
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blotting analysis showed that ATX protein is expressed in both RCC and BC, and the expression levels were 69.5 and 48.0 %, respectively, higher in RCC and BC carcinoma tissue samples than in the adjacent normal tissues, which is consistent with the results of immunohistochemistry study.
|
27757783 |
2016 |
|
Carcinoma of lung
|
0.040 |
Biomarker
|
disease |
BEFREE |
The decreased MARVELD1 level in lung cancer reduces NMD efficiency through diminishing the association between NMD complex component UPF1/SMG1 and premature termination codons containing mRNA (PTC-mRNA).
|
25520033 |
2014 |
|
Carcinoma of lung
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In mice, total loss of SMG1 is embryonic lethal and loss of a single allele results in an increased rate of cancer development, particularly haematopoietic cancers and lung cancer.
|
31565865 |
2019 |
|
Carcinoma of lung
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here we use both preclinical models of lung cancer and clinical samples (from patients and healthy controls) to investigate the expression levels, activity, and biological role of the above components of the ATX/LPA axis in lung cancer.
|
29724718 |
2018 |
|
Carcinoma of lung
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We compared the anti-tumor activity of ATX-s10-PDT against lung cancer cell lines SBC-3 and SBC-3/VEGF, the latter overexpressing VEGF; there was no significant difference in the sensitivity to the PDT between the two cell lines as assessed by clonogenic assay.
|
17671719 |
2007 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the expression of the human PD-Ialpha/ATX gene in human neuroblastoma tumor tissues and the motility stimulating activity of recombinant ATX on neuroblastoma cells and investigated its transcriptional regulatory mechanism in a human neuroblastoma cell line.
|
9192834 |
1997 |
|
Cerebral Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective of this study is to investigate neuroprotection of ATX pretreatment and its mechanisms in the hippocampal cornu ammonis 1 (CA1) region following transient global cerebral ischemia in gerbils.
|
28356001 |
2017 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the role of C/EBPβ in PR-B expression regulation in glioblastoma cell lines, which expressed different ratios of PR and C/EBPβ isoforms (LAP1, LAP2, and LIP).
|
27663075 |
2017 |