|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study suggests that pharmacological inhibition of ATX could be a therapeutic strategy in colitis.-Lin, S., Haque, A., Raeman, R., Guo, L., He, P., Denning, T. L., El-Rayes, B., Moolenaar, W. H., Yun, C. C. Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.
|
30481488 |
2019 |
|
Hyperthyroidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study explores the first-in-human use of antigen-specific immunotherapy with a combination of two thyrotropin receptor (TSHR) peptides (termed ATX-GD-59) in Graves' hyperthyroidism.
|
31194638 |
2019 |
|
Mental deterioration
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Exposure to TAC-induced systolic hypertension promoted cerebrovascular damage and cognitive decline in WT mice, similar to those observed in sham-operated ATX mice; TAC exacerbated the existing cerebrovascular dysfunctions and cognitive failure in ATX mice.
|
31093829 |
2019 |
|
Chronic colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
ATX blockade was able to relieve symptoms and inflammatory response of DSS-induced chronic colitis.
|
31102124 |
2019 |
|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that SMG1 is a novel PC susceptibility gene, and we identified specific SMG1 gene variants associated with PC risk.
|
31469826 |
2019 |
|
Impaired cognition
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Exposure to TAC-induced systolic hypertension promoted cerebrovascular damage and cognitive decline in WT mice, similar to those observed in sham-operated ATX mice; TAC exacerbated the existing cerebrovascular dysfunctions and cognitive failure in ATX mice.
|
31093829 |
2019 |
|
Acute and chronic colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
ATX expression was increased upon induction of colitis, whereas ATX deletion reduced the severity of inflammation in both acute and chronic colitis, accompanied by transient weight loss.
|
30481488 |
2019 |
|
Chronic ulcerative colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, it is unclear whether ATX-LPA axis affects the differentiation of Th17 cells in chronic UC.
|
31102124 |
2019 |
|
Nasopharyngeal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MicroRNA-18a promotes cancer progression through SMG1 suppression and mTOR pathway activation in nasopharyngeal carcinoma.
|
31659158 |
2019 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this paper, we have studied the involvement of three PIKK family members in colon cancer cell senescence and connection between DNA-damage-induced senescence and NF-κB-regulated SASP in p53-proficient and p53-deficient colon cancer cells treated with doxorubicin.
|
29352261 |
2018 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In early stage of diabetic mellitus (DM), rats were administrated with CoQ10-LIP followed by UTMD (CoQ10-LIP+UTMD) to prevent occurrence of DN.
|
29589596 |
2018 |
|
Tuberculosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genome sequence of Mycobacterium tuberculosis revealed the presence of several hydrolases involved in lipid metabolism including the members of Lip gene family.Rv0646c (LipG) is one of them.
|
29388150 |
2018 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this paper, we have studied the involvement of three PIKK family members in colon cancer cell senescence and connection between DNA-damage-induced senescence and NF-κB-regulated SASP in p53-proficient and p53-deficient colon cancer cells treated with doxorubicin.
|
29352261 |
2018 |
|
Malignant Pleural Mesothelioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We investigated if LIP levels can predict the clinical response to cisplatin and survival of MPM patients receiving cisplatin-based chemotherapy.
|
29748013 |
2018 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated the efficacy of genetic (C/EBP-β LIP induction) and pharmacological strategies (lysosome and proteasome inhibitors), in restoring the ER-dependent and immunogenic-dependent cell death induced by doxorubicin, in vitro and in syngeneic mice bearing chemoresistant TNBC.
|
30482226 |
2018 |
|
High grade serous carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, LPAR mRNA and ATX protein levels are anatomic site-dependent in HGSC and the former are informative of disease outcome.
|
30032361 |
2018 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated the efficacy of genetic (C/EBP-β LIP induction) and pharmacological strategies (lysosome and proteasome inhibitors), in restoring the ER-dependent and immunogenic-dependent cell death induced by doxorubicin, in vitro and in syngeneic mice bearing chemoresistant TNBC.
|
30482226 |
2018 |
|
Biliary Atresia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Subsequent analysis revealed that BA patients with advanced stage had lower methylation levels of ATX promoter than those with early stage.
|
28052132 |
2017 |
|
Cerebral Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective of this study is to investigate neuroprotection of ATX pretreatment and its mechanisms in the hippocampal cornu ammonis 1 (CA1) region following transient global cerebral ischemia in gerbils.
|
28356001 |
2017 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the role of C/EBPβ in PR-B expression regulation in glioblastoma cell lines, which expressed different ratios of PR and C/EBPβ isoforms (LAP1, LAP2, and LIP).
|
27663075 |
2017 |
|
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, inhibiting ATX-lysophosphatidic acid (LPA) signalling reduced HCV replication, demonstrating a positive role for this phospholipase in the viral life cycle.
|
28126468 |
2017 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
ATX has additional abilities such as antagonistic effects on the N-methyl-Daspartate receptors (NMDARs) and benefit effects in some animal models of neurological disorders.
|
28356001 |
2017 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the role of C/EBPβ in PR-B expression regulation in glioblastoma cell lines, which expressed different ratios of PR and C/EBPβ isoforms (LAP1, LAP2, and LIP).
|
27663075 |
2017 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the role of C/EBPβ in PR-B expression regulation in glioblastoma cell lines, which expressed different ratios of PR and C/EBPβ isoforms (LAP1, LAP2, and LIP).
|
27663075 |
2017 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
ATX pretreatment reduced ischemia-induced hyperactivity and protected CA1 pyramidal neurons from ischemia.
|
28356001 |
2017 |