|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Moreover, we show that overexpression of GOF mutant p53 G245D decreases the AMP-activated protein kinase (AMPK)-mediated phosphorylation of FOXO3a, a tumor suppressive forkhead transcription factor, leading to its cytoplasmic accumulation.
|
29269868 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Overexpression of either <i>O</i>-GlcNAcylated FOXO3 (FOX-OV) or a Ser-to-Ala mutant (S284A) in PANC-1 cells indicated that S284 <i>O</i>-GlcNAc acts as a critical block of the FOXO tumor suppressor and induces proliferation in PANC-1 cancer cells by stimulating the MDM2-p53-p21 axis.
|
29301793 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Microarray analysis suggested that cGMP inhibited Forkhead box O3 (FOXO3), which is known as a tumor suppressor.
|
27893718 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The results of this study revealed that the oncogenic effect of BRAF(V600E) is associated with the inhibition of MST1 tumor suppressor pathways, and that the activity of RASSF1A-MST1-FoxO3 pathways determines the phenotypes of BRAF(V600E) tumors.
|
21249150 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings highlight that PP2A antagonizes the prosurvival pathways controlled by Akt, which phosphorylates and thereby suppresses a variety of pro-apoptotic factors and tumour suppressors including Bad and FoxO3a.
|
30353029 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings challenge the current paradigm that nuclear export regulates the proteolysis of FOXO3A/4 tumour suppressors in the context of cancer and illustrates how oncogenic RAS-mediated degradation of FOXOs, via post-translational mechanisms, blocks these important tumour suppressors.
|
28945225 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The influence of FOXO3a on tumor metastasis was also studied in vivo orthotopic xenograft tumor model.
|
24486593 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, our findings reveal the functional role of the PI3K/Akt/FoxO3a pathway that gets deregulated in cancer and suggests its simultaneous targeting by RLX thereby further identifying the compound as a potent inhibitor of the PI3K/Akt/FoxO3a pathway under in vitro and tumour regression in vivo.
|
25554016 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FOXO3a is an essential tumor suppressor that regulates the mechanisms of tumorigenesis and leukemogenesis.
|
25060657 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In summary, our results show that selenite could induce ROS-dependent FoxO3a-mediated apoptosis in CRC cells and xenograft tumors through PTEN-mediated inhibition of the PI3K/AKT survival axis.
|
23392169 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, vascular endothelial cell-specific knockout of FoxO3a in mice could disrupt the anti-angiogenesis effect of As<sub>2</sub>O<sub>3</sub> and endow the tumors with resistance to As<sub>2</sub>O<sub>3</sub> treatments.
|
31421153 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In chorioallantoic membrane (CAM) assays STA-NB15 tumors with ectopic FOXO3 showed increased micro-vessel formation and, when xenografted into nude mice, a gene-dosage-dependent effect of FOXO3 in high-stage STA-NB15 cells became evident: low-level activation increased tumor-vascularization, whereas hyper-activation repressed tumor growth.The combined data suggest that, depending on the mode and intensity of activation, cellular FOXO3 acts as a homeostasis regulator promoting tumor growth at hypoxic conditions and tumor angiogenesis in high-stage neuroblastoma.
|
27769056 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The FOXO3 is a tumor suppressor gene and found to interact with p53, the trigger for apoptosis through BCl2 family genes and a regulator of Notch signaling pathway for the self-renewal of stem cells.
|
30205794 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In an in vivo model, combination therapy of Ad-FKHRL1/TM with TMZ results in greater tumor growth reduction in comparison with single treatments.
|
25238278 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings demonstrate that silencing FOXO3a promotes tumor radioresistance of NPC in vitro and in vivo through inducing EMT and activating Wnt/β-catenin signal pathway.
|
31022422 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by inducing growth arrest and apoptosis.
|
15668399 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor suppressor forkhead Box O3 is another substrate of proteasomal degradation, which also functions partially through inducing apoptosis.
|
28220348 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We recently demonstrated that p38α is required to maintain colorectal cancer (CRC) metabolism, as its inhibition leads to FoxO3A activation, autophagy, cell death, and tumor growth reduction both in vitro and in vivo.
|
22579651 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our results suggest that SUMOylation positively regulates FOXK2 transcriptional activity and has a role in mediating the cytotoxic response to paclitaxel through the tumour suppressor FOXO3.
|
29540677 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Forkhead transcription factors of the O class 3a (FoxO3a), an important regulator of cell survival, has been reported with dual functions in tumor recently.
|
27825133 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The transcription factor forkhead box O 3A (FOXO3A) is a tumor suppressor that promotes cell cycle arrest and apoptosis.
|
30753811 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FOXO3a induces the factors that contribute to cell cycle arrest and is considered a tumor suppressor in several malignant tumors.
|
27699813 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Forkhead Box O3 (FOXO3) is a tumor suppressor whose activity is fine-tuned by post-translational modifications (PTMs).
|
31357743 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis.
|
31488102 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Forkhead box O3 (FOXO3) has a wide range of functions: it promotes tumor suppression, cell cycle arrest, repair of damaged DNA, detoxification of reactive oxygen species, apoptosis and plays a pivotal role in promoting longevity.
|
21725602 |
2011 |