|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor suppressor FOXO3 regulates gene expression and its translocation to the cytosol leads to the abrogation of its transcriptional function.
|
19636295 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor suppressor forkhead Box O3 is another substrate of proteasomal degradation, which also functions partially through inducing apoptosis.
|
28220348 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor bearing mice hearts show increased expression and nuclear localization of TFEB and FoxO3a transcription factors, which are involved in the upregulation of muscle atrophy genes, lysosomal biogenesis genes and autophagy genes.
|
29618792 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Forkhead box O3 (FOXO3) has a wide range of functions: it promotes tumor suppression, cell cycle arrest, repair of damaged DNA, detoxification of reactive oxygen species, apoptosis and plays a pivotal role in promoting longevity.
|
21725602 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FOXO3A has been implicated in tumor suppression and GC-induced apoptosis, suggesting that FOXO3A has potential as a therapeutic target.
|
22582938 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor role.
|
23828518 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FOXO3a is an essential tumor suppressor that regulates the mechanisms of tumorigenesis and leukemogenesis.
|
25060657 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FOXO3a functions like a typical tumour suppressor, whereas FOXM1 is a potent oncogene aberrantly overexpressed in genotoxic resistant cancers.
|
25418858 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis.
|
26657152 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FOXO3a induces the factors that contribute to cell cycle arrest and is considered a tumor suppressor in several malignant tumors.
|
27699813 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FOXO3a is a key regulator of apoptosis and a tumor suppressor in several cancer types.
|
30172026 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
FOXO3 is a tumor suppressor that orchestrates the expression of genes that regulate cell cycle progression, apoptosis, metabolism, oxidative stress, and other important cellular processes.
|
30414146 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Forkhead Box O3 (FOXO3) is a tumor suppressor whose activity is fine-tuned by post-translational modifications (PTMs).
|
31357743 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FoxO3a is a well-defined tumor suppressor gene in the forkhead transcription factor O subfamily (FoxO), and its reduction is related to the occurrence of various tumors.
|
31599414 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FOXO3a has been widely regarded as a tumor suppressor.
|
31629677 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FoxO3a is a well-defined tumor suppressor gene in the forkhead transcription factor O subfamily (FoxO), and its reduction is related to the occurrence of various tumors.
|
31771044 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, frequencies and the function of FOXO3 expressed by DC subsets that infiltrate tumors vary between genders.
|
28229217 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
And systemic delivery of miR-10b-3p antagomir reduced tumor growth and inhibit FOXO3 protein expression in nude mice.
|
30514328 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our results suggest that SUMOylation positively regulates FOXK2 transcriptional activity and has a role in mediating the cytotoxic response to paclitaxel through the tumour suppressor FOXO3.
|
29540677 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cotreatment with doxorubicin and MDM2 inhibitor, Nutlin-3, further enforced abundant nuclear accumulation of FOXO3a resulting in decrease expression of DNMT3B leading to synergistic inhibition of tumor growth and decrease of methylation status on tumor suppressor genes in xenograft specimens.
|
25122426 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Despite observing a positive association between the LKB1 and FOXO3 expression levels in the tumors, this association was not statistically significant (P = 0.24).
|
23810581 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Despite the central role of FOXO3 as a tumour suppressor and phosphatidylinositol 3-kinase (PI3K)/AKT effector, little is known about its involvement in mantle cell lymphoma (MCL) biology.
|
22107151 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
EGCG-treated mice showed significant inhibition in tumor growth which was associated with reduced phosphorylation of ERK, PI3K, AKT, and FKHRL1/FOXO3a, and modulation of FOXO target genes.
|
22971992 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Emerging evidences indicate that FOXO3a acts as a tumor suppressor in cancer.
|
30045773 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Epidermal growth factor (EGF)-induced proliferation of colon cancer cells plays an important role in colon cancer progression and is mediated by loss of tumor suppressor FOXO3 activity.
|
21639915 |
2011 |